Results 41 to 50 of about 4,028,312 (182)

Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

, 2022
Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P.
Barennes, H., Sirima, S. B., Simpson, J. A., Juma, E., Sutanto, I., Fukuda, M., Menard, D., Stepniewska, K., Woodrow, C. J., Kayentao, K., Moore, B. R., Premji, Z., Allen, E. N., Yeka, A., Adam, I., Koram, K., Fogg, C., Nahum, A., Burrow, R., Ogutu, B. R., Barnes, K. I., Das, S., Grais, R. F., Kiechel, J. R., Nji, A. M., Asih, P. B. S., Tjitra, E., Greenwood, B., Alemayehu, B. H., Menan, H., Das, D., Dondorp, A. M., Mbacham, W., Carrara, V. I., Karema, C., Ouedraogo, J. B., Laman, M., White, N. J., Newton, P. N., Mansoor, R., Osorio, L., Starzengruber, P., Rombo, L., Same-Ekobo, A., Baudin, E., Drakeley, C. J., Desai, M., Hodel, E. M., Douglas, N. M., Mayxay, M., Valea, I., Rahim, A. G., Pareek, A., Rosenthal, P. J., Price, R. N., Kamya, M. R., Ashurst, H., von Seidlein, L., Piola, P., Anvikar, A. R., Talisuna, A. O., Gaye, O., Smithuis, F. M., Noedl, H., Toure, O. A., Kamugisha, E., Cot, M., Ursing, J., Mockenhaupt, F., Grandesso, F., Swarthout, T. D., Bassat, Q., Humphreys, G. S., Achan, J., Richmond, C. L., Kager, P. A., Etard, J. F., Adjei, G. O., Bukirwa, H., Muller, O., Tran, T. H., Yavo, W., Adjuik, M., Bethell, D., Bousema, T., D'Alessandro, U., Ojurongbe, O., Roper, C., Kremsner, P. G., Owusu-Agyei, S., Bakyaita, N., Were, V., Arinaitwe, E., Ishengoma, D., Valentini, G., McGready, R., Lee, S. J., Ashley, E. A., Basco, L., Djimde, A. A., Gonzalez, R., Nikiema, F., Staedke, S. G., Faucher, J. F., Boulton, C., Strub-Wourgaft, N., Gilayeneh, J., Filler, S., Nosten, F., Syafruddin, D., Bjorkman, A., Martensson, A., Ndiaye, J. L., Lalloo, D. G., Zongo, I., Ward, S. A., Abuaku, B., Hatz, C., Plucinski, M., Allan, R., Falade, C., Brasseur, P., Temu, E. A., Espie, E., Duparc, S., Kazienga, A., Genton, Blaise, Commons, R. J., Maiga, A. W., Thwing, J. I., van Vugt, M., Guerin, P. J., Ramharter, M., Penali, L. K., Salman, S., Some, F. A., Kofoed, P. E., Dorsey, G., Bell, D. J., Kachur, S. P., Taylor, W. R., Tinto, H., Davis, T. M. E., Lell, B., Grivoyannis, A., Ngasala, B. E., Hwang, J., Sibley, C.   +147 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Assessing antimalarial efficacy in a time of change to artemisinin-based combination therapies: the role of Médecins Sans Frontières. [PDF]

, 2008
Jean-Paul Guthmann and colleagues describe the output of MSF's work in antimalarial efficacy assessment during the last ...
Comte, Eric, Legros, Dominique, Francesco Checchi, Philippe J Guerin, Balkan Suna, Kindermans Jean-Marie, van den Broek Ingrid, Guerin Philippe J, van Herp, Michel, van den Broek, Ingrid, Checchi, Francesco, Ingrid van den Broek, Oscar Bernal, Guerin, Philippe J, Jean-Marie Kindermans, Dominique Legros, Jean-Paul Guthmann, Comte Eric, Michel van Herp, Guthmann Jean-Paul, Venis Sarah, Sarah Venis, Kindermans, Jean-Marie, van Herp Michel, Checchi Francesco, Guthmann, Jean-Paul, Legros Dominique, Eric Comte, Guerin, Philippe, Venis, Sarah, Suna Balkan, Bernal Oscar, Balkan, Suna, Bernal, Oscar   +33 more
core   +1 more source

An Update on Development of Small-Molecule Plasmodial Kinase Inhibitors

Molecules, 2020
Malaria control relies heavily on the small number of existing antimalarial drugs. However, recurring antimalarial drug resistance necessitates the continual generation of new antimalarial drugs with novel modes of action.
Chantalle Moolman, Rencia van der Sluis, Richard M. Beteck, Lesetja J. Legoabe   +3 more
doaj   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

PfMDR1: mechanisms of transport modulation by functional polymorphisms. [PDF]

PLoS ONE, 2011
ATP-Binding Cassette (ABC) transporters are efflux pumps frequently associated with multidrug resistance in many biological systems, including malaria.
Pedro Eduardo Ferreira, Gabrielle Holmgren, Maria Isabel Veiga, Per Uhlén, Akira Kaneko, José Pedro Gil   +5 more
doaj   +1 more source

Annona squamosa: Phytochemical Fingerprinting, Health‐Improving Traits, and Functional Applications

Food Chemistry International, EarlyView.
Annona squamosa (custard apple) is a nutrient‐rich fruit containing diverse bioactive phytochemicals (e.g., acetogenins, flavonoids, and alkaloids) that contribute to multiple health benefits, including antioxidant, antihyperlipidemic, and antimicrobial activities, highlighting its potential as a functional food and medicinal resource.
Mohamed Fawzy Ramadan, Jumanah Reda Kurdi, Manar Yahya Alzahrani, Asmaa Ibrahim Alshaikhi, Jumanah Samir Hazzazi   +4 more
wiley   +1 more source

Antimalarial drug resistence and artemisinin based combination therapy : a bio-economic model for elucidating policy choices [PDF]

Antimalarial drug resistance is a major cause of the increasing burden due to P. falciparum malaria. Artemisinin-based combination therapies (ACTs) are now recognised to be the ideal choice for the first-line treatment of ...
Yeung, Shunmay
core   +1 more source

A broad analysis of resistance development in the malaria parasite

Nature Communications, 2016
It is unclear whether new antimalarial compounds may rapidly lose effectiveness in the field because of parasite resistance. Here, Corey et al.investigate the acquisition of drug resistance and the extent to which common resistance mechanisms decrease ...
Victoria C. Corey, Amanda K. Lukens, Eva S. Istvan, Marcus C. S. Lee, Virginia Franco, Pamela Magistrado, Olivia Coburn-Flynn, Tomoyo Sakata-Kato, Olivia Fuchs, Nina F. Gnädig, Greg Goldgof, Maria Linares, Maria G. Gomez-Lorenzo, Cristina De Cózar, Maria Jose Lafuente-Monasterio, Sara Prats, Stephan Meister, Olga Tanaseichuk, Melanie Wree, Yingyao Zhou, Paul A. Willis, Francisco-Javier Gamo, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler   +25 more
doaj   +1 more source

Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum

Infectious Disease Modelling, 2017
Background: The use of poor quality antimalarial medicines, including the use of non-recommended medicines for treatment such as sulfadoxine-pyrimethamine (SP) monotherapy, undermines malaria control and elimination efforts.
Aleisha R. Brock, Joshua V. Ross, Scott Greenhalgh, David P. Durham, Alison Galvani, Sunil Parikh, Adrian Esterman   +6 more
doaj   +1 more source