Results 21 to 30 of about 4,028,312 (182)

Artemisinin resistance and malaria elimination: Where are we now?

Frontiers in Pharmacology, 2022
The emergence of artemisinin resistance is a major obstacle to the global malaria eradication/elimination programs. Artemisinin is a very fast-acting antimalarial drug and is the most important drug in the treatment of severe and uncomplicated malaria ...
Borimas Hanboonkunupakarn, Borimas Hanboonkunupakarn, Joel Tarning, Joel Tarning, Sasithon Pukrittayakamee, Sasithon Pukrittayakamee, Sasithon Pukrittayakamee, Kesinee Chotivanich, Kesinee Chotivanich, Kesinee Chotivanich   +9 more
doaj   +1 more source

A novel antimalarial lead compound: in vitro properties and mode of action studies [PDF]

, 2011
Malaria remains a major public health problem and the increasing number of resistant strains underscores the need for new drugs with new modes of action (MOAs).
Brunner, Ralf Oskar
core   +1 more source

Artemisinin resistance in Plasmodium falciparum malaria. [PDF]

, 2009
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
Yi, Poravuth, Singhasivanon, Pratap, Day, Nicholas PJ, Ariey, Frederic, Lindegardh, Niklas, Lim, Pharath, Dondorp, Arjen M, Ringwald, Pascal, Socheat, Duong, Hanpithakpong, Warunee, Silamut, Kamolrat, Lwin, Khin Maung, Imwong, Mallika, Phyo, Aung Phae, Das, Debashish, Lee, Sue J, Herdman, Trent, White, Nicholas J, Chotivanich, Kesinee, Yeung, Shunmay, Tarning, Joel, Nosten, François, An, Sen Sam   +22 more
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World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs. [PDF]

, 2007
The proliferation of antimalarial drug trials in the last ten years provides the opportunity to launch a concerted global surveillance effort to monitor antimalarial drug efficacy. The diversity of clinical study designs and analytical methods undermines
Laufer, M K, Sibley, C H, Stepniewska, Barnes, K I, Guerin, P J, Philippe J Guerin, Ringwald, P, Grant Dorsey, Olliaro, P., Naidoo, I, J Kevin Baird, Stepniewska, K., d'Alessandro, U, Olliaro, P, Miriam K Laufer, Guerin, Philippe J, d\u27Alessandro, Umberto, Guerin, Philippe J., Laufer, M. K., François Nosten, D'Alessandro, U., Price, R N, Pascal Ringwald, Ringwald, Pascal, Barnes, Karen, Dorsey, G, d'Alessandro, Umberto, Barnes, K. I., Baird, J. Kevin, Inbarani Naidoo, Nicholas J White, Ashley, Elizabeth A, Stepniewska, K, Guerin, Philippe, Sibley, C. H., Naidoo, I., Christopher V Plowe, Ashley, E. A., Baird, J K, Sibley, Carol H, Ashley, Elizabeth A., White, Nicholas J., Nosten, F., White, N. J., Price, Ric, Dorsey, Grant, Plowe, C V, Ashley, E A, Plowe, Christopher, Carol H Sibley, Baird, K., Barnes, Karen I., White, Nicholas J, Laufer, Miriam K, Umberto d'Alessandro, Elizabeth A Ashley, Plowe, Christopher V., Nosten, F, White, N J, Karen I Barnes, Guerin, P. J., Baird, J Kevin, Piero Olliaro, Plowe, C. V., Barnes, Karen I, Price, R. N., Sibley, Carol H., Dorsey, G., Price, Ric N., Plowe, Christopher V, Ringwald, P., Sibley, Carol, Laufer, Miriam K., Naidoo, Inbarani, Stepniewska, Kasia, Ashley, Elizabeth, Price, Ric N, Ric N Price, Kasia Stepniewska, Laufer, Miriam, Olliaro, Piero, Stepniewska Kasia, Ringwald Pascal, Price Ric N, Nosten François, d'Alessandro Umberto, Olliaro Piero, White Nicholas J, Baird J Kevin, Barnes Karen I, Guerin Philippe J, Dorsey Grant, Sibley Carol H, Ashley Elizabeth A, Naidoo Inbarani, Laufer Miriam K, Plowe Christopher V, Nosten, Francois   +97 more
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Expanding the Antimalarial Drug Arsenal—Now, But How?

Pharmaceuticals, 2011
The number of available and effective antimalarial drugs is quickly dwindling. This is mainly because a number of drug resistance-associated mutations in malaria parasite genes, such as crt, mdr1, dhfr/dhps, and others, have led to widespread resistance ...
Rajeev K. Mehlotra, Brian T. Grimberg
doaj   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +21 more
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Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations

International Journal for Parasitology: Drugs and Drug Resistance, 2021
The use of antimalarial drugs is an effective strategy in the fight against malaria. However, selection of drug resistant parasites is a constant threat to the continued use of this approach.
Yaye Die Ndiaye, Daniel L. Hartl, David McGregor, Aida Badiane, Fatou Ba Fall, Rachel F. Daniels, Dyann F. Wirth, Daouda Ndiaye, Sarah K. Volkman   +8 more
doaj   +1 more source

"Plasmodium falciparum" drug resistance, molecular genotyping and generation of a malaria resistance genogram by DNA microarray-based technology [PDF]

, 2006
Prior to the 2001 malarial treatment policy change in Tanzania, studies were conducted to assess the efficacy of sulfadoxine-pyrimethamine (SP) and usefulness of molecular markers in monitoring SP resistance.
Mugittu, Kefas Nasongelya
core   +1 more source

Extensive Drug Resistance in Malaria and Tuberculosis

Emerging Infectious Diseases, 2010
Drug resistance in malaria and in tuberculosis (TB) are major global health problems. Although the terms multidrug-resistant TB and extensively drug-resistant TB are precisely defined, the term multidrug resistance is often loosely used when discussing ...
Chansuda Wongsrichanalai, Jay K. Varma, Jonathan J. Juliano, Michael E. Kimerling, John R. MacArthur   +4 more
doaj   +1 more source

Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. [PDF]

, 2015
BACKGROUND: In Nigeria, despite the change in National malaria drug policy to artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance, chloroquine (CQ) is still widely used in the treatment of malaria because it is cheap ...
Sutherland, Colin J, Oladipo, Oladosu O, Wellington, Oyibo A   +2 more
core   +1 more source