Results 11 to 20 of about 4,028,312 (182)

The rationale and plan for creating a World Antimalarial Resistance Network (WARN) [PDF]

Malaria Journal, 2007
Drug resistant malaria was a major factor contributing to the failure of a worldwide campaign to eradicate malaria in the last century, and now threatens the large investment being made by the global community in the rollout of effective new drug ...
Plowe Christopher V, Barnes Karen I, Sibley Carol   +2 more
doaj   +2 more sources

Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria : a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data [PDF]

, 2015
BACKGROUND: Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well
Bassat Orellana, Quique, WorldWide Antimalarial Resistance Network (WWARN), Mårtensson, A, Sibley, CH, Nsanzabana, C, Bassat, Q, Ringwald, P, Faucher, JF, WorldWide Antimalarial Resistance Network Lumefantrine PK/PD Stu,, Ashley, EA, Hodel, EM, Lindegardh, NL, Davis, TME, Schramm, B, Lefèvre, G, Parikh, S, Mayxay, M, Van Vugt, M, Borrmann, S, Hamed, K, Jullien, V, Workman, LJ, Newton, PN, Stepniewska, K, Genton, B, Kiechel, JR, null null, Rombo, L, Kofoed, PE, Piola, P, Barnes, KI, Dahal, P, Aweeka, F, Moreira, C, Kofoed, Poul-Erik, Tarning, J, Nosten, F, Djimde, AA, Ursing, J, Ngasala, BE, Deloron, P, Karunajeewa, HA, Guérin, PJ, Denis, MB, Marsh, K, Price, RN, White, NJ, Huang, L, Mcgready, R   +48 more
core   +3 more sources

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Sibley, CH, Malmberg, M, Nsobya, SL, Lebras, J, Nsanzabana, C, Faucher, JF, Thwing, J, Somé, AF, Ogutu, B, Houzé, S, Gadalla, NB, Björkman, A, Desai, M, Schramm, B, Venkatesan, M, Oguike, M, Ménard, D, Hamour, S, Plowe, CV, Dhorda, M, Djimdé, AA, Borrmann, S, Dorsey, G, Wong, RP, Fröberg, G, Stepniewska, K, Guérin, P, Kiechel, JR, Baliraine, FN, Johnson, J, Rombo, L, Kariuki, S, Ouédraogo, JB, Ademowo, G, Kofoed, PE, Grivoyannis, A, Falade, C, Sutherland, CJ, Nzila, A, Piola, P, Zongo, I, Eshetu, T, Dahal, P, Kamugisha, E, Ngasala, B, El-Sayed, BB, Rosenthal, PJ, Nosten, F, Eyase, F, Ursing, J, Otienoburu, SD, Davis, TM, Adam, I, Kironde, F, Zeynudin, A, Checchi, F, Moriera, C, Arze, C, Berens-Riha, N, Mwai, L, Price, RN, Faucher, Jean-François, Houzé, Sandrine, Somé, A Fabrice, Sutherland, Colin, Checchi, Francesco, Berens-Riha, Nicole, Davis, Timothy ME, Björkman, Anders, Asaq Molecular Marker Study Group, Rosenthal, Philip, Eyase, Frederick, Kariuki, Simon, Mårtensson, Andreas,, Davis, Timothy, Gadalla, Nahla B, Ménard, Didier, Arze, Cesar, Djimdé, Abdoulaye A, Fröberg, Gabrielle, Ursing, Johan, Desai, Meghna, Mårtensson, Andreas, Ouédraogo, Jean-Bosco, Mwai, Leah, Kironde, Fred, Djimde, Abdoulaye, Dorsey, Grant, Johnson, Jacob, Guérin, Philippe, Somé, A. Fabrice, Oguike, Alexis Nzila Mary, LeBras, Poul-Erik Kofoed Jacques, Kofoed, Poul-Erik, Dahal, Prabin, Nzila, Alexis, Wong, Rina PM, Nsobya, Samuel L, Zongo, Issaka, Gadalla, Nahla, Dhorda, Meghna Desai Mehul, Plowe, Christopher,, Rombo, Lars,, Stepniewska, Kasia, Adam, Ishag, Price, Ric N, Rombo, Lars, Kamugisha, Erasmus, Piola, Patrice, El-Sayed, Badria, Plowe, Christopher, V, Sutherland, Colin J, Otienoburu, Sabina Dahlström, Grivoyannis, Anastasia, Malmberg, Maja, Hamour, Sally, Ogutu, Bernhards, Wong, Rina, Sibley, Carol Hopkins, Ngasala, Billy, Oguike, Mary, Venkatesan, Meera, Baliraine, Frederick N, LeBras, Jacques, El-Sayed, Badria B, Thwing, Julie, Price, Ric, Moriera, Clarissa, Kiechel, Jean-René, Nsanzabana, Christian, Rosenthal, Philip J, Ademowo, George, Falade, Catherine, Schramm, Birgit, Wong, Rina P M, Plowe, Christopher V, Eshetu, Teferi, Davis, Timothy M E, Dhorda, Mehul, Borrmann, Steffen, Nosten, Francois, Baliraine, Frederick, Zeynudin, Ahmed, Nsobya, Samuel, Martensson, A   +144 more
core   +2 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

The efficacy of antimalarial monotherapies, sulphadoxine-pyrimethamine and amodiaquine in East Africa: implications for sub-regional policy. [PDF]

, 2003
Between 1998 and 2001, Kenya, Uganda, Tanzania, Zanzibar, Rwanda and Burundi changed antimalarial drug policy, in the face of widespread chloroquine resistance.
East African Network for Monitoring Antimalarial Treatment (EANMAT), East African Network for Monitoring Antimalarial Treatment (EANM   +1 more
core   +1 more source

The perils of PCR: can we accurately 'correct' antimalarial trials? [PDF]

, 2010
During follow-up in antimalarial drug trials, treated subjects can be newly infected. PCR correction is used to distinguish this re-infection from drug failure (recrudescence) and to adjust final drug efficacy estimates.
Sutherland, Colin J, Juliano, Jonathan J, Gadalla, Nahla, Meshnick, Steven R., Meshnick, Steven R, Juliano, Jonathan J., Sutherland, Colin J.   +6 more
core   +1 more source

Review of Atypical Organometallic Compounds as Antimalarial Drugs

Journal of Chemistry, 2020
Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug ...
Samuel K. Kwofie, Emmanuel Broni, Bismark Dankwa, Kweku S. Enninful, Joshua Teye, Cedar R. Davidson, Josephine B. Nimely, J. Chioma Orizu, Prakasha Kempaiah, Brijesh Rathi, Whelton A. Miller   +10 more
doaj   +1 more source

Evaluation of the Effect of Gene Duplication by Genome Editing on Drug Resistance in Plasmodium falciparum

Frontiers in Cellular and Infection Microbiology, 2022
The emergence and spread of drug-resistant Plasmodium falciparum have compromised antimalarial efficacy and threatened the global malaria elimination campaign using artemisinin combination therapies.
Rie Kubota, Tomoko Ishino, Shiroh Iwanaga, Naoaki Shinzawa   +3 more
doaj   +1 more source

Surveillance of Antimalarial Drug-Resistance Genes in Imported Plasmodium falciparum Isolates From Nigeria in Henan, China, 2012–2019

Frontiers in Cellular and Infection Microbiology, 2021
Malaria remains a major public health issue in Nigeria, and Nigeria is one of the main sources of imported malaria in China. Antimalarial drug resistance is a significant obstacle to the control and prevention of malaria globally.
Dongyang Zhao, Hongwei Zhang, Penghui Ji, Suhua Li, Chengyun Yang, Ying Liu, Dan Qian, Yan Deng, Hao Wang, Deling Lu, Ruimin Zhou, Yuling Zhao   +11 more
doaj   +1 more source

Capacity Development through the US President’s Malaria Initiative–Supported Antimalarial Resistance Monitoring in Africa Network

Emerging Infectious Diseases, 2017
Antimalarial drug resistance is an evolving global health security threat to malaria control. Early detection of Plasmodium falciparum resistance through therapeutic efficacy studies and associated genetic analyses may facilitate timely implementation of
Eric S. Halsey, Meera Venkatesan, Mateusz M. Plucinski, Eldin Talundzic, Naomi W. Lucchi, Zhiyong Zhou, Celine I. Mandara, Hawela Moonga, Busiku Hamainza, Abdoul Habib Beavogui, Simon Kariuki, Aaron M. Samuels, Laura C. Steinhardt, Don P. Mathanga, Julie Gutman, Yves Eric Denon, Aline Uwimana, Ashenafi Assefa, Jimee Hwang, Ya Ping Shi, Pedro Rafael Dimbu, Ousmane Koita, Deus S. Ishengoma, Daouda Ndiaye, Venkatachalam Udhayakumar   +24 more
doaj   +1 more source