Results 31 to 40 of about 4,028,312 (182)

Distribution pattern of amino acid mutations in chloroquine and antifolate drug resistance associated genes in complicated and uncomplicated Plasmodium vivax isolates from Chandigarh, North India

BMC Infectious Diseases, 2020
Background The increasing antimalarial drug resistance is a significant hindrance to malaria control and elimination programs. For the last six decades, chloroquine (CQ) plus pyrimethamine remains the first-line treatment for P. vivax malaria.
Hargobinder Kaur, Rakesh Sehgal, Archit Kumar, Praveen K. Bharti, Devendra Bansal, Pradyumna K. Mohapatra, Jagadish Mahanta, Ali A. Sultan   +7 more
doaj   +1 more source

High resistance of Plasmodium falciparum to sulphadoxine/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581. [PDF]

, 2009
BACKGROUND: Sulphadoxine-pyrimethamine (SP) a widely used treatment for uncomplicated malaria and recommended for intermittent preventive treatment of malaria in pregnancy, is being investigated for intermittent preventive treatment of malaria in infants
Gesase Samwel, Daniel Chandramohan, Mosha Jacklin F., Mandia, Victor, Joho, Angel, Victor Mandia, Martha Lemnge, Greenwood, Brian, Samwel Gesase, Gesase, Samwel, Chandramohan Daniel, Mosha Frank W., Savael, Zacharia, Ord, Rosalynn, Roper, Cally, Angel Joho, Madebe, Rashid, Greenwood Brian, Hashim Ramadhan, Frank W. Mosha, Mrema Hedwiga, Inbarani Naidoo, Chandramohan, Daniel, Zacharia Savael, Mapunda Ephraim, Mosha, Frank W, Lemnge Martha, Madebe Rashid, Rosalynn Ord, Mapunda, Ephraim, Ephraim Mapunda, Roly D Gosling, Naidoo Inbarani, Frank W Mosha, Hashim, Ramadhan, Cally Roper, Mandia Victor, Gosling, Roly D, Victor M, Jacklin F. Mosha, Gosling Roly D., Lemnge, Martha, Ord Rosalynn, Hedwiga Mrema, Brian Greenwood, Mrema, Hedwiga, Roly D. Gosling, Roper Cally, Jacklin F Mosha, Ramadhan Hashim, Rashid Madebe, Mosha, Jacklin F, Naidoo, Inbarani, Savael Zacharia, Joho Angel   +54 more
core   +2 more sources

The Impact of Antimalarial Use on the Emergence and Transmission of Plasmodium falciparum Resistance: A Scoping Review of Mathematical Models

Tropical Medicine and Infectious Disease, 2017
The emergence and transmission of resistance to antimalarial treatments continue to hamper malaria elimination efforts. A scoping review was undertaken regarding the impact of antimalarial treatment in the human population on the emergence and ...
Aleisha R. Brock, Carole A. Gibbs, Joshua V. Ross, Adrian Esterman   +3 more
doaj   +1 more source

Different methodological approaches to the assessment of in vivo efficacy of three artemisinin-based combination antimalarial treatments for the treatment of uncomplicated falciparum malaria in African children. [PDF]

, 2008
BACKGROUND: Use of different methods for assessing the efficacy of artemisinin-based combination antimalarial treatments (ACTs) will result in different estimates being reported, with implications for changes in treatment policy.
Pinoges Loretxu, Balkan, S, Grant Dorsey, Pinoges, Loretxu, Hasifa Burkirwa, Olliaro, P, Pedro Pablo Palma Urruta, Checchi, Francesco, Ingrid van den Broek, Dorsey Grant, Urruta, P P P, Walter R Taylor, Michel van Herp, Ashley Elizabeth A, Dorsey, G, van Herp Michel, Turyakira, Eleanor, Guthmann, Jean-Paul, Ashley, Elizabeth A, Zongo Issaka, Taylor Walter R, van Herp, M, Francesco Checchi, Issaka Zongo, Turyakira, E, Zongo, I, Taylor, W R J, Balkan Suna, Dorsey, Grant, van den Broek Ingrid, van Herp, Michel, Ashley, E A, van den Broek, Ingrid, Taylor, Walter R, Urruta, Pedro Pablo Palma, Elizabeth A Ashley, Eleanor Turyakira, Olliaro Piero, Pinoges, L, Jean-Paul Guthmann, Guthmann, J P, Guthmann Jean-Paul, van den Broek, I, Piero Olliaro, Zongo, Issaka, Checchi Francesco, Bukirwa, H, Checchi, F, Loretxu Pinoges, Bukirwa, Hasifa, Turyakira Eleanor, Suna Balkan, Bukirwa Hasifa, Urruta Pedro, Balkan, Suna, Olliaro, Piero   +55 more
core   +1 more source

Quality of antimalarial drugs and antibiotics in Papua New Guinea : a survey of the health facility supply chain [PDF]

, 2014
Poor-quality life-saving medicines are a major public health threat, particularly in settings with a weak regulatory environment. Insufficient amounts of active pharmaceutical ingredients (API) endanger patient safety and may contribute to the ...
Betuela Inoni, Davis, T., Page-Sharp Madhu, Betuela, I., Page-Sharp, Madhu, Bala, Nancy, Bala Nancy, Manuel W Hetzel, Timothy M E Davis, Evelyn K Lavu, Pulford Justin, Lavu, Evelyn K., Nancy Bala, Nancy Bala (563875), Hetzel Manuel W., Davis Timothy M. E., Madhu Page-Sharp (563874), Evelyn K. Lavu (563877), Davis, Timothy M. E., Lavu Evelyn K., Justin Pulford, Lavu, E., Bala, N., Pulford, J., Madhu Page-Sharp, Betuela, Inoni, Inoni Betuela, Hetzel, M., Hetzel, Manuel W., Pulford, Justin, Justin Pulford (563876), Inoni Betuela (67110), Timothy M. E. Davis (112260), Manuel W. Hetzel (563873), Pulford J, Hetzel MW, Lavu EK, Betuela I, Bala N, Page-Sharp M, Davis TM   +40 more
core   +2 more sources

Antimalarial Drug Resistance and Novel Targets for Antimalarial Drug Discovery

Infection and Drug Resistance, 2020
Melkamu Adigo Shibeshi, Zemene Demelash Kifle, Seyfe Asrade Atnafie Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Zemene Demelash KifleDepartment of ...
Shibeshi MA, Kifle ZD, Atnafie SA
doaj  

Drug resistant falciparum malaria and the use of artesunate-based combinations : focus on clinical trials sponsored by TDR [PDF]

Journal of Vector Borne Diseases, 2003
Antimalarial drug resistance has now become a serious global challenge and is the principal reasonfor the decline in antimalarial drug efficacy. Malaria endemic countries need inexpensive and efficaciousdrugs.
Walter R.J. Taylor, Jean Rigal & Piero L. Olliaro
doaj  

A database of antimalarial drug resistance

Malaria Journal, 2006
A large investment is required to develop, license and deploy a new antimalarial drug. Too often, that investment has been rapidly devalued by the selection of parasite populations resistant to the drug action.
Ringwald Pascal, Sibley Carol
doaj   +1 more source

Inhibitors of the Plasmodium falciparum Hsp90 towards Selective Antimalarial Drug Design: The Past, Present and Future

Cells, 2021
Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public health threat. The development of antimalarial drug resistance is reversing the gains made in attempts to control the disease.
Melissa Louise Stofberg, Celine Caillet, Marianne de Villiers, Tawanda Zininga   +3 more
doaj   +1 more source

Modelling the impact of intermittent preventive treatment for malaria on selection pressure for drug resistance. [PDF]

, 2007
BACKGROUND\ud \ud Intermittent preventive treatment (IPT) is a promising intervention for malaria control, although there are concerns about its impact on drug resistance.\ud \ud METHODS\ud \ud The key model inputs are age-specific values for a) baseline
Sutherland Colin, Schellenberg, David, Roper, C., Schellenberg, D., Roper Cally, Roper, Cally, Sutherland, C., Cissé, Badara, Alexander, N., Alexander Neal, Sutherland, Colin, Schellenberg David, Cissé Badara, Alexander, Neal, Neal Alexander, Colin Sutherland, Cally Roper, David Schellenberg, Badara Cissé   +18 more
core   +1 more source