Results 51 to 60 of about 4,028,312 (182)

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Acridine-Based Antimalarials—From the Very First Synthetic Antimalarial to Recent Developments

Molecules, 2021
Malaria is among the deadliest infectious diseases in the world caused by Plasmodium parasites. Due to the high complexity of the parasite’s life cycle, we partly depend on antimalarial drugs to fight this disease.
Mélanie Fonte, Natália Tassi, Paula Gomes, Cátia Teixeira   +3 more
doaj   +1 more source

Applications of nanocarrier‐delivered RNA interference in agricultural biological control (2009–2025)

New Plant Protection, EarlyView.
Despite 17 years of development, the effectiveness of nanocarrier‐delivered RNAi pesticide (NDRP) for agricultural biological control remains limited. The successful development of effective NDRP development requires the coordinated optimization of target gene selection and nanocarrier properties, including RNA dosage, multi‐gene targeting, protection ...
Shi Dong Wang, Woo‐Jong Hong, Xu Jiang, Ki‐hong Jung, Yuan Hu Xuan   +4 more
wiley   +1 more source

Historical evolution and molecular mechanisms of antimalarial drug resistance with emerging challenges and future directions

Discover Public Health
Malaria remains a major global public health concern, particularly in low- and middle-income countries, where it continues to cause substantial morbidity and mortality.
Osazuwa John Patrick, Adewale Allen Sokan-Adeaga, Rachael Olaide Emmanuel   +2 more
doaj   +1 more source

Antimalarial herbal drugs: a review of their interactions with conventional antimalarial drugs

Clinical Phytoscience, 2021
Development of resistance by malaria parasites to conventional antimalarial drugs has rejuvenated the exploration of herbal medicine as alternatives. Also, the increasing rate of the use of herbal antimalarial remedies in combination with conventional ...
Earnest Oghenesuvwe Erhirhie, Chidozie Ikegbune, Anthony Ifeanyi Okeke, Chukwunonso Chukwudike Onwuzuligbo, Ngozi Ukamaka Madubuogwu, Uche Maryann Chukwudulue, Onyinye Blessing Okonkwo   +6 more
doaj   +1 more source

Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer

Phytotherapy Research, EarlyView.
Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer. ABSTRACT Dihydroartemisinin (DHA), a bioactive derivative of Artemisia annua L. (AAL), has shown antitumor activity in several malignancies, including non‐small cell lung cancer (NSCLC).
Xiuli Guo, Gan Tao, Mini Zhang, Linzhi Han, Sisi Yan, Chunsheng Wang, Jianguo Zhang, Xiaowan Guo, Kehua Hu, Yan Gong, Qiuji Wu, Conghua Xie   +11 more
wiley   +1 more source

Concurrence of Plasmodium falciparum dhfr and crt mutations in northern Ghana. [PDF]

, 2005
BACKGROUND: Both chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) are failing drugs in much of sub-Saharan Africa. Previous findings suggest an association between resistance to CQ and to SP in vivo, in vitro, and on the molecular level.
Bousema J Teun, Sauerwein, Robert W, Teunis A Eggelte, Bienzle Ulrich, Bousema, J Teun, Ehrhardt, Stephan, Eggelte Teunis A, Mockenhaupt Frank P, Ehrhardt Stephan, Otchwemah, Rowland N, Bienzle, Ulrich, Mockenhaupt, Frank P, J Teun Bousema, Rowland N Otchwemah, Eggelte, Teunis A, Ulrich Bienzle, Stephan Ehrhardt, Otchwemah Rowland N, Sauerwein Robert W, Frank P Mockenhaupt, Robert W Sauerwein   +20 more
core   +1 more source

Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro

Stem Cell Reports, 2015
Malaria eradication is a major goal in public health but is challenged by relapsing malaria species, expanding drug resistance, and the influence of host genetics on antimalarial drug efficacy.
Shengyong Ng, Robert E. Schwartz, Sandra March, Ani Galstian, Nil Gural, Jing Shan, Mythili Prabhu, Maria M. Mota, Sangeeta N. Bhatia   +8 more
doaj   +1 more source

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Pharmacovigilance of antimalarial treatment in Africa: is it possible? [PDF]

, 2006
Pharmacovigilance, defined as "the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other possible drug related problem", is increasingly being recognized in Africa.
Talisuna, Ambrose O, Staedke Sarah G, D'Alessandro, U., Sarah G Staedke, Talisuna, A. O., Ambrose O Talisuna, Staedke, S. G., Staedke, Sarah G, Talisuna Ambrose O, Umberto D'Alessandro, D'Alessandro, Umberto, D'Alessandro Umberto   +11 more
core   +1 more source