New approaches in antimalarial drug discovery and development: a review
Memorias do Instituto Oswaldo Cruz, 2012 Malaria remains a major world health problem following the emergence and spread of Plasmodium falciparum that is resistant to the majority of antimalarial drugs.
Anna Caroline C Aguiar +4 more
doaj +1 more source
Requirements for Diagnosis of Malaria at Different Levels of the Laboratory Network in Africa. [PDF]
, 2009 The rapid increase of resistance to cheap, reliable antimalarials, the increasing cost of effective drugs, and the low specificity of clinical diagnosis has increased the need for more reliable diagnostic methods for malaria.
Barnish +5 more
core +1 more source
Cell-Cycle-Associated Amplified Genomic-DNA Fragments (CAGFs) Might Be Involved in Chloroquine Action and Resistance in Plasmodium falciparum [PDF]
arXiv, 2017 As a cheap and safe antimalarial agent, chloroquine (CQ) has been used in the battle against malaria for more than half century. However, the mechanism of CQ action and resistance in Plasmodium falciparum remains elusive. Based on further analysis of our published experimental results, we propose that the mechanism of CQ action and resistance might be ...
arxiv
Antimalarial Artefenomel Inhibits Human SARS-CoV-2 Replication in Cells while Suppressing the Receptor ACE2 [PDF]
arXiv, 2020 The steep climbing of victims caused by the new coronavirus disease 2019 (COVID-19) throughout the planet is sparking an unprecedented effort to identify effective therapeutic regimens to tackle the pandemic. The SARS-CoV-2 virus is known to gain entry into various cell types through the binding of one of its surface proteins (spike) to the host ...
arxiv
npj VaccinesIn preparation for mass vaccinations with R21/Matrix-M™ combined with mass administrations of dihydroartemisinin, piperaquine, and a single low dose primaquine we assessed the tolerability, safety, and potential interactions of this combination affecting
Borimas Hanboonkunupakarn +18 more
doaj +1 more source
A rare case of melanosis of the hard palate mucosa in a patient with chronic myeloid leukemia [PDF]
, 2015 Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a ...
Bosco, Daniela +4 more
core +3 more sources
Rotating-crystal Malaria Diagnosis: Pre-clinical validation [PDF]
arXiv, 2013 Improving the efficiency of malaria diagnosis is one of the main goals of current malaria research. We have recently developed a magneto-optical (MO) method which allows high-sensitivity detection of malaria pigment (hemozoin) crystals via their magnetically induced rotation in blood. Here, we validate this technique on laboratory derived blood samples
arxiv
Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar. [PDF]
, 2004 Multi-drug resistant falciparum malaria is widespread in Asia. In Thailand, Cambodia and Vietnam the national protocols have changed largely to artesunate combined treatment regimens but elsewhere in East and South Asia chloroquine (CQ) and sulfadoxine ...
Aung-Than-Batu H +9 more
core +2 more sources
Hydroxychloroquine‐induced erythema multiforme
Clinical Case Reports, 2020 Hydroxychloroquine is a commonly used medication and rarely may result in development of erythema multiforme. This potential cutaneous side effect should be highlighted in information given to patients prior to hydroxychloroquine commencement.
Dimitra Koumaki +10 more
doaj +1 more source
Comparación de técnicas in vitro para detectar resistencia de Plasmodium falciparum a medicamentos
Biomédica: revista del Instituto Nacional de Salud, 1999 Debido a que la resistencia de Plasmodium falciparuma medicamentos se percibe como uno de los problemas que más agrava la situación de la malaria en Colombia, existe la necesidad de implementar procedimientos que permitan hacer una búsqueda amplia y ...
Jacqueline Chaparro, Moisés Wasserman
doaj +1 more source