Results 91 to 100 of about 51,125 (324)
Pfcrmp May Play a Key Role in Chloroquine Antimalarial Action and Resistance Development [PDF]
arXiv, 2015 It was proposed earlier that Pfcrmp (Plasmodium falciparum chloroquine resistance marker protein) may be the chloroquine's target protein in nucleus. In this communication, further evidence is presented to support the view that Pfcrmp may play a key role in chloroquine antimalarial actions as well as resistance development.
arxiv
Chemistry &Biodiversity, EarlyView.ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
The challenge of chloroquine-resistant malaria in sub-Saharan Africa.
, 2001 For the last decade chloroquine-resistant Plasmodium falciparum (CRPF) has spread explosively in sub-Saharan Africa. In some areas of the continent, CRPF is so intense that chloroquine can hardly be said to have any efficacy.
Nuwaha, F
core +1 more source
Requirements for Diagnosis of Malaria at Different Levels of the Laboratory Network in Africa. [PDF]
, 2009 The rapid increase of resistance to cheap, reliable antimalarials, the increasing cost of effective drugs, and the low specificity of clinical diagnosis has increased the need for more reliable diagnostic methods for malaria.
Barnish +5 more
core +1 more source
Characterization of the Cubamyces Menziesii Terpenome
ChemBioChem, EarlyView.The genome of Cubamyces menziesii reveals 18 putative sesquiterpene cyclase genes. These genes are cloned and expressed in Escherichia coli, yielding 10 active enzymes. Using farnesyl diphosphate as substrate, the enzymes are analyzed, and the products characterized after bioconversion, uncovering diverse sesquiterpene structures. This study highlights
Létitia Leydet +10 more
wiley +1 more source
Antimalarials and the eye [PDF]
, 1989 Following the first reports in 1954 of the beneficial effects of chloroquine in cases of lupus erythematosus, this drug and its numerous derivatives have been used extensively in the treatment of systemic and discoid lupus erythematosus and rheumatoid ...
Coleiro, Joseph A.
core
A dynamic stress model explains the delayed drug effect in artemisinin treatment of Plasmodium falciparum [PDF]
, 2016 Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria. With alternative antimalarial drugs not yet available, improving our understanding of how artemisinin-based drugs act and how resistance manifests is essential to enable optimisation of dosing regimens in order to prolong the lifespan of current ...
arxiv +1 more source
ChemBioChem, Accepted Article.Flavin‐dependent halogenases (FDHs) carry out substrate‐specific and regioselective halogenation reactions in the biosynthesis of various halogenated natural compounds. Several FDHs convert non‐native substrates in vitro. However, obtaining experimental structures of FDHs with non‐native substrates remains challenging and docking often produces ...
Simon Bork +3 more
wiley +1 more source
, 2010 We characterized vaccine-induced cellular responses to rabies virus in naive adult volunteers. Contrary to current paradigms, we observed potent and prolonged in vitro NK cell cytokine production and degranulation responses after restimulation of PBMCs ...
Behrens, Ron H +4 more
core +1 more source
Intermittent Preventive Treatment (IPT): Its role in averting disease-induced mortalities in children and in promoting the spread of antimalarial drug resistance [PDF]
arXiv, 2017 We develop a variable population age-structured ODE model to investigate the role of Intermittent Preventive Treatment (IPT) in averting malaria-induced mortalities in children, as well as its related cost in promoting the spread of anti-malarial drug resistance.
arxiv