Results 151 to 160 of about 51,125 (324)
Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes
Annals of Human Genetics, EarlyView.ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott +3 more
wiley +1 more source
Molecular Determinants of Orthosteric-allosteric Dual Inhibition of PfHT1 by Computational Assessment [PDF]
arXivTo overcome antimalarial drug resistance, carbohydrate derivatives as selective PfHT1 inhibitor have been suggested in recent experimental work with orthosteric and allosteric dual binding pockets. Inspired by this promising therapeutic strategy, herein, molecular dynamics simulations are performed to investigate the molecular determinants of co ...
arxiv
British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda +2 more
wiley +1 more source
Understanding erythroid physiology and pathology in humanized mice: A closer look
British Journal of Haematology, Volume 206, Issue 5, Page 1272-1284, May 2025.Erythropoiesis, the formation of red blood cells (RBCs) from haematopoietic stem cells (HSCs), is vital for understanding conditions like anaemia and haemoglobinopathies. However, studying this process in vivo is challenging due to the lack of accurate models.
Lu Lu +7 more
wiley +1 more source
THE ACTION OF ANTIMALARIAL DRUGS IN MICE INFECTED WITH PLASMODIUM BERGHEI [PDF]
, 1950 June P. Thurston
openalex +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Systemic lupus erythematosus is an autoimmune, multisystemic disease affecting all organs in the body. Accrued evidence has elucidated a role for autophagy in the onset and severity of systemic lupus erythematosus. The antimalarial drug hydroxychloroquine constitutes the cornerstone of standard of care for systemic lupus ...
Eya Toumi +10 more
wiley +1 more source
Editorial: Frontiers in malaria research
Frontiers in Microbiology, 2023 Ritu Gill +5 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani +4 more
wiley +1 more source
Effectiveness of Antimalarial Drugs
New England Journal of Medicine, 2005 A global resurgence of malaria has taken place as a result of a lapse in preventive efforts and the emergence of resistance to standard antimalarial drugs. New therapies are available, but because of social, economic, and clinical factors, the use of older drugs persists.
openaire +4 more sources