Results 11 to 20 of about 92,770 (362)
Arthritis & Rheumatology, 2022 The pathogenesis of cutaneous lupus erythematosus (CLE) is multifactorial, and CLE is difficult to treat due to the heterogeneity of inflammatory processes among patients.
J. Patel +12 more
semanticscholar +1 more source
Acridine-Based Antimalarials—From the Very First Synthetic Antimalarial to Recent Developments
Molecules, 2021 Malaria is among the deadliest infectious diseases in the world caused by Plasmodium parasites. Due to the high complexity of the parasite’s life cycle, we partly depend on antimalarial drugs to fight this disease.
Mélanie Fonte +3 more
semanticscholar +1 more source
The Ototoxicity of Antimalarial Drugs—A State of the Art Review
Frontiers in Neurology, 2021 This review summarizes current knowledge about the occurrence of hearing and balance disorders after antimalarial drugs treatment. It also examines the clinical applications of antimalarials, their mechanisms behind this ototoxicity and how it can be ...
Magdalena Jozefowicz-Korczynska +2 more
doaj +1 more source
Evaluation of In-Hospital Management for Febrile Illness\ud in Northern Tanzania before and after 2010 World Health\ud Organization Guidelines for the Treatment of Malaria [PDF]
, 2014 In 2010, the World Health Organization (WHO) published updated guidelines emphasizing and expanding recommendations for a parasitological confirmation of malaria before treating with antimalarials. This study aimed to assess differences in historic (2007–
Biggs, Holly M. +6 more
core +14 more sources
Molecules, 2022 Malaria chemotherapy is greatly threatened by the recent emergence and spread of resistance in the Plasmodium falciparum parasite against artemisinins and their partner drugs. Therefore, it is an urgent priority to develop new antimalarials. Plasmepsin V
Xin Ji +6 more
doaj +1 more source
Pharmaceuticals, 2021 Plasmodium spp. malaria parasites in the blood stage draw energy from anaerobic glycolysis when multiplying in erythrocytes. They tap the ample glucose supply of the infected host using the erythrocyte glucose transporter 1, GLUT1, and a hexose ...
Cornelius Nerlich +3 more
doaj +1 more source
New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria [PDF]
Journal of the Serbian Chemical Society, 2021 Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P.
Opsenica Igor +7 more
doaj +1 more source
Pioneer Use of Antimalarial Transdermal Combination Therapy in Rodent Malaria Model
Pathogens, 2023 We have previously reported 1,2,6,7-tetraoxaspiro [7.11]nonadecane (N-89) as a promising antimalarial compound. In this study, we evaluated the effect of transdermal therapy (tdt) of N-89 in combination (tdct) with other antimalarials as an application ...
Nagwa S. M. Aly +8 more
doaj +1 more source
Frontiers in Microbiology, 2022 IntroductionIn spite of promising medical, sociological, and engineering strategies and interventions to reduce the burden of disease, malaria remains a source of significant morbidity and mortality, especially among children in sub-Saharan Africa.
Tomasz A. Leski +13 more
doaj +1 more source
Biomolecules, 2020 Chemotherapy plays a key role in breast cancer therapy, but drug resistance and unwanted side effects make the treatment less effective. We propose a new combination model that combines antineoplastic drugs and antimalarials for breast cancer therapy ...
Diana Duarte, N. Vale
semanticscholar +1 more source