Results 11 to 20 of about 51,125 (324)

Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination [PDF]

Gerardin et al. BMC Infectious Diseases (2015) 15:144, 2015
Antimalarial drugs are a powerful tool for malaria control and elimination. Artemisinin-based combination therapies (ACTs) can reduce transmission when widely distributed in a campaign setting. Modelling mass antimalarial campaigns can elucidate how to most effectively deploy drug-based interventions and quantitatively compare the effects of cure ...
Eckhoff, Philip, Gerardin, Jaline, Wenger, Edward A.   +2 more
arxiv   +3 more sources

Forensic investigation of falsified antimalarials using isotope ratio mass spectrometry: a pilot investigation [PDF]

Scientific Reports
We explored whether isotope ratio mass spectrometry (IRMS) is useful to investigate the origin of falsified antimalarials. Forty-four falsified and genuine antimalarial samples (artesunate, artemether-lumefantrine, dihydroartemisinin-piperaquine and ...
Paul N. Newton, Lesley A. Chesson, Mayfong Mayxay, Arjen Dondorp, Patricia Tabernero, John D. Howa, Thure E. Cerling   +6 more
doaj   +2 more sources

Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology

Frontiers in Pharmacology, 2021
Malaria is an endemic disease that affected 229 million people and caused 409 thousand deaths, in 2019. Disease control is based on early diagnosis and specific treatment with antimalarial drugs since no effective vaccines are commercially available to ...
Isabela P. Ceravolo, Anna C. Aguiar, Joseph O. Adebayo, Antoniana U. Krettli   +3 more
doaj   +1 more source

New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria [PDF]

Journal of the Serbian Chemical Society, 2021
Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P.
Opsenica Igor, Selaković Milica, Tot Mikloš, Verbić Tatjana, Srbljanović Jelena, Štajner Tijana, Đurković-Đaković Olgica, Šolaja Bogdan   +7 more
doaj   +1 more source

High adherence to antimalarials and antibiotics under integrated community case management of illness in children less than five years in eastern Uganda. [PDF]

PLoS ONE, 2013
BackgroundDevelopment of resistance to first line antimalarials led to recommendation of artemisinin based combination therapies (ACTs). High adherence to ACTs provided by community health workers (CHWs) gave reassurance that community based ...
Joan N Kalyango, Elizeus Rutebemberwa, Charles Karamagi, Edison Mworozi, Sarah Ssali, Tobias Alfven, Stefan Peterson   +6 more
doaj   +1 more source

The Ototoxicity of Antimalarial Drugs—A State of the Art Review

Frontiers in Neurology, 2021
This review summarizes current knowledge about the occurrence of hearing and balance disorders after antimalarial drugs treatment. It also examines the clinical applications of antimalarials, their mechanisms behind this ototoxicity and how it can be ...
Magdalena Jozefowicz-Korczynska, Anna Pajor, Weronika Lucas Grzelczyk   +2 more
doaj   +1 more source

Evaluation of In-Hospital Management for Febrile Illness\ud in Northern Tanzania before and after 2010 World Health\ud Organization Guidelines for the Treatment of Malaria [PDF]

, 2014
In 2010, the World Health Organization (WHO) published updated guidelines emphasizing and expanding recommendations for a parasitological confirmation of malaria before treating with antimalarials. This study aimed to assess differences in historic (2007–
Biggs, Holly M., Crump, John A., Maro, Venace P., Moon, Andrew M., Reddy, Elizabeth A., Rubach, Matthew P., Saganda, Wilbrod   +6 more
core   +12 more sources

Integrated Phenotypic and Genotypic Approaches for Accurate Diagnosis of G6PD Deficiency: Implications for Drug Safety in Thailand. [PDF]

Pharmacol Res Perspect
ABSTRACT Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency holds critical health concerns, particularly due to its association with drug‐induced hemolysis triggered by medications such as antimalarials. This condition poses significant risks in malaria‐endemic regions where the prevalence and genetic diversity of G6PD deficiency further complicate ...
Pengsuk N, Chamchoy K, Duangdee C, Satayarak J, Saralamba N, Nguitragool W, Boonyuen U.   +6 more
europepmc   +2 more sources

Prevalence of malaria resistance-associated mutations in Plasmodium falciparum circulating in 2017–2018, Bo, Sierra Leone

Frontiers in Microbiology, 2022
IntroductionIn spite of promising medical, sociological, and engineering strategies and interventions to reduce the burden of disease, malaria remains a source of significant morbidity and mortality, especially among children in sub-Saharan Africa.
Tomasz A. Leski, Chris Rowe Taitt, Sophie M. Colston, Umaru Bangura, Andrew Holtz, Chadwick Y. Yasuda, Nathanael D. Reynolds, Joseph Lahai, Joseph M. Lamin, Victoria Baio, Rashid Ansumana, Rashid Ansumana, David A. Stenger, Gary J. Vora   +13 more
doaj   +1 more source

Discovery and Development of Inhibitors of the Plasmodial FNT-Type Lactate Transporter as Novel Antimalarials

Pharmaceuticals, 2021
Plasmodium spp. malaria parasites in the blood stage draw energy from anaerobic glycolysis when multiplying in erythrocytes. They tap the ample glucose supply of the infected host using the erythrocyte glucose transporter 1, GLUT1, and a hexose ...
Cornelius Nerlich, Nathan H. Epalle, Philip Seick, Eric Beitz   +3 more
doaj   +1 more source