Results 81 to 90 of about 33,834 (203)
Pfcrmp May Play a Key Role in Chloroquine Antimalarial Action and Resistance Development [PDF]
arXiv, 2015 It was proposed earlier that Pfcrmp (Plasmodium falciparum chloroquine resistance marker protein) may be the chloroquine's target protein in nucleus. In this communication, further evidence is presented to support the view that Pfcrmp may play a key role in chloroquine antimalarial actions as well as resistance development.
arxiv
A dynamic stress model explains the delayed drug effect in artemisinin treatment of Plasmodium falciparum [PDF]
, 2016 Artemisinin resistance constitutes a major threat to the continued success of control programs for malaria. With alternative antimalarial drugs not yet available, improving our understanding of how artemisinin-based drugs act and how resistance manifests is essential to enable optimisation of dosing regimens in order to prolong the lifespan of current ...
arxiv +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2003 La resistencia a los antimaláricos es una de las causas del aumento de casos de malaria en el mundo. Desde el año 2000, el tratamiento de malaria no complicada por Plasmodium falciparum en Colombia ha sido la combinación de amodiaquina (AQ) y sulfadoxina/
Iveth J. González +3 more
doaj +1 more source
Malaria in the 21st century - still a threatening problem [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2019 There are six parasite species (P. falciparum, P. vivax, P. ovale curtisi, P. ovale wallikeri, P. malariae, and P. knowlesi) that cause malaria in humans. P. falciparum is responsible for most malaria-related deaths globally. P.
Čanović Predrag +2 more
doaj +1 more source
, 2010 We characterized vaccine-induced cellular responses to rabies virus in naive adult volunteers. Contrary to current paradigms, we observed potent and prolonged in vitro NK cell cytokine production and degranulation responses after restimulation of PBMCs ...
Behrens, Ron H +4 more
core +1 more source
Discovering Antimalarials [PDF]
Chemistry & Biology, 2002 Recent discoveries have uncovered some key processes that occur in the food vacuole of the malarial parasite. Consequently, new families of potential antimalarials that inhibit HRP-2, a hitherto unexplored drug target, were identified using a novel screening method.
openaire +3 more sources
The challenge of chloroquine-resistant malaria in sub-Saharan Africa.
, 2001 For the last decade chloroquine-resistant Plasmodium falciparum (CRPF) has spread explosively in sub-Saharan Africa. In some areas of the continent, CRPF is so intense that chloroquine can hardly be said to have any efficacy.
Nuwaha, F
core +1 more source
Intermittent Preventive Treatment (IPT): Its role in averting disease-induced mortalities in children and in promoting the spread of antimalarial drug resistance [PDF]
arXiv, 2017 We develop a variable population age-structured ODE model to investigate the role of Intermittent Preventive Treatment (IPT) in averting malaria-induced mortalities in children, as well as its related cost in promoting the spread of anti-malarial drug resistance.
arxiv
Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?
Memorias do Instituto Oswaldo Cruz, 2014 In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned ...
Fernando Fonseca Val +6 more
doaj +1 more source
Nucleus may be the key site of chloroquine antimalarial action and resistance development [PDF]
arXiv, 2017 The first proposed hypothesis about the mechanism of chloroquine (CQ) action on malaria parasites is DNA intercalation hypothesis which indicates that the site of CQ action is within the nucleus. Later on the interest of research was shifted from nucleus to lysosome due to the report of CQ accumulation within lysosome.
arxiv