Results 41 to 50 of about 6,952 (109)

Economic burden of hospital admissions for adverse drug reactions in France: The IATROSTAT‐ECO study

British Journal of Clinical Pharmacology, Volume 91, Issue 2, Page 439-450, February 2025.
Aims Hospitalizations for adverse drug reactions (ADR‐HA) have increased over the last decade, but the impact of ADR‐HA has rarely been evaluated. The aim of this study was to estimate the economic burden of ADR‐HA in France. Methods A partial economic evaluation from the viewpoint of French public health insurance was performed, based on a previous ...
Marie‐Laure Laroche, Noémie Tarbouriech, Taha Jai, Marie‐Blanche Valnet‐Rabier, Virginie Nerich   +4 more
wiley   +1 more source

The synergy between alkylating agents and ERCC1–XPF inhibitors is p53 dependent

Fundamental &Clinical Pharmacology, Volume 39, Issue 1, February 2025.
Abstract Background DNA repair plays a major role in maintaining genomic stability, thus limiting the transformation of normal cells into cancer cells. However, in cancer patients treated with DNA‐targeting drugs, DNA repair can decrease efficacy by removing the damage generated by such molecules that is needed to induce pharmacological activity ...
Gloria Ciniero, Tiago Marques Pedro, Charles Dumontet, Ahmed H. Elmenoufy, Frederick G. West, Michael Weinfeld, Francesco Gentile, Jack A. Tuszynski, Emeline Cros‐Perrial, Lars Petter Jordheim   +9 more
wiley   +1 more source

Synthesis and antitumor testing of certain new fused triazolopyrimidine and triazoloquinazoline derivatives [PDF]

, 2017
New series of 1,2,4-triazolopyrimidine and 1,2,4-triazoloquinazoline derivatives were designed, synthesized, and evaluated for their antitumor activity.
Badria, Farid A., Bayomi, Said M., El-Ashmawy, Mahmoud B., El-Sherbeny, Magda A., Hassan, Ghada S., Maarouf, Azza R.   +5 more
core   +2 more sources

Antineoplastic Agent: Chemotherapeutic Treatment to Fight against Cancer [PDF]

, 2012
A neoplasm or tumor is a abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of the normal tissue and continues in the same manner after cessation of the stimuli which have initiated it. A malignant tumor grows rapidly and
Babu Bodla, Ramesh, Mujoriya, Rajesh
core   +1 more source

A simple and robust method for connecting small-molecule drugs using gene-expression signatures [PDF]

, 2008
Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with similar ...
B Efron, CC Ting, J Frasor, J Lamb, JD Storey, JJ Chen, JS Warrington, KB Glaser, L Tian, M Lee, N Fujimoto, N Sathyamoorthy, PA Horwitz, R Januchowski, S McHugh, SD Zhang, Shu-Dong Zhang, ST Matalon, Timothy W Gant, VW Armstrong, Y Chen   +20 more
core   +5 more sources

Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis [PDF]

, 2013
Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity ...
Bailey H. H., Ballestrero A., Bellamy W. T., Betanzos-Lara S., Bozic I., Bushra Qamar, Carew J. S., Castonguay A., Chan J., Constantini P., Dai Y., Degterev A., Dindo D., Doroshow J. H., Dyke M. W. Van, Fagan V., Finnilä S., Frank J. E., Fu Y., Fu Y., Gaiddon C., Garbutcheon-Singh K. B., Hannon M. J., Hartinger C. G., Hileman E. A., Holbeck S., Huo H., Ian Hands-Portman, Isolda Romero-Canelón, Jessica M. Hearn, Jordan M. A., Jungwirth U., Kelland L., Kerr J. F., Kroemer G., Lazebnik Y. A., Liu Z., Liu Z., Liu Z., Lu J.-J., McKeage M. J., Millar A. W., Monneret C., Nagata S., Park G. Y., Paull K., Perchellet E. M., Peter J. Sadler, Petrelli A., Pittella F., Porteous C. M., Pracharova J., Purewal M., Rai S. S., Rixe O., Saraste A., Shoemaker R. H., Shoemaker R. H., Siddik Z., Sidler D., Tsutsui T., Türk D., Van den Bogert C., Zalacaín M., Zhang Y.-W., Zhe Liu, Zhou D.-F., Zhu Z.   +67 more
core   +1 more source

Acute toxicity of novel N-sulfonylpyrimidine derivatives in vivo [PDF]

The aim of the present study was to investigate in vivo toxic effects and to find acute toxic doses (LD 50) of novel N-sulfonyl derivatives of pyrimidine nucleobases uracil and cytosine. Six N-1-sulfonyluracil derivatives (1, 2, 6, 7, 8, and 9) and two N-
Biserka Žinić, Jure Jerčić, Ksenija Vlahović, Marina Pavlak, Marko Radačić, Ranko Stojković   +5 more
core  

UA94/6/15 Student / Alumni Personal Papers WKU Dorris Hutchinson [PDF]

, 2015
Correspondence and publications created by and about the Dorris Hutchison during her time at Sloan-Kettering ...
WKU Archives
core   +1 more source

Aplicação de SMILES strings na identificação de grupos funcionais responsáveis pela atividade biológica em compostos medicinais [PDF]

, 2018
An efficient and practical approach to identification of important functional groups in the structure of medicinal molecules that are main factor to create biological activity by use of SMILES line notation system is described.
Maslehat, Sholeh, Nickchi, Payman, Sardari, Soroush, Soheilizad, Mehdi   +3 more
core   +1 more source

Effect of cisplatin in Mytilus galloprovincialis and of cyclophosphamide, tamoxifen and cisplatin on Ca2+ATPase [PDF]

, 2015
Relatório de Estágio de Licenciatura, Biologia Marinha, Faculdade de Ciências e Tecnologias da Universidade do Algarve, 2015In the last decade anti-cancer drugs, such as cisplatin, tamoxifen and cyclophosphamide, have seen their use greatly increase ...
Morais, Matilde
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