Results 41 to 50 of about 7,527 (154)

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects [PDF]

, 2013
Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which ...
A Ashkenazi, A Ashkenazi, A Chuntharapai, A Mohr, A Mohr, A Mohr, A Mohr, A Nakamizo, A Peister, AM van der Sloot, B Hall, C Buneker, CR Reis, D Sampath, D Stadel, DR Camidge, EW Duiker, FP Barry, GS Wu, GS Wu, I Nicoletti, J Lemke, J Luetzkendorf, JW Schymkowitz, K Ichikawa, K Papenfuss, L Zhang, LG Menon, LS Sasportas, M MacFarlane, M Vogler, M Vogler, M Vogler, ME Davis, MH Kim, MR Loebinger, MR Sprick, RM Zwacka, RW Johnstone, SB Bratton, SJ Braeuer, SM Albarenque, SM Kim, T Trarbach, TK Oost, TM Ganten, TS Griffith   +46 more
core   +1 more source

Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains

Journal of Applied Toxicology, Volume 46, Issue 2, Page 682-696, February 2026.
ABSTRACT Coagulant Moringa oleifera lectin (cMoL) is one of the compounds involved in the application of M. oleifera seeds for traditional water treatment methods. The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against Cryptococcus neoformans B3501 and H99 and Cryptococcus gattii R265 strains ...
Matheus Cavalcanti de Barros, Sávia Soraia Santana da Silva, Eduarda Pinto Gagliano, Alícia Natalie Silva dos Santos, Leydianne Leite de Siqueira Patriota, Gustavo Ramos Salles Ferreira, Pollyanna Michelle da Silva, Simone da Paz Leôncio Alves, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Fernanda Rafaelly Nascimento de Santana, Fabiana Aparecida Cavalcante Silva, Marilene Henning Vainstein, Luana Cassandra Breitenbach Barroso Coelho, Thâmarah de Albuquerque Lima, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva   +16 more
wiley   +1 more source

Increased Skeletal Muscle Fat in Patients With Haematological Cancer Is Associated With Reduced Cardiorespiratory Fitness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Patients with haematological cancer often exhibit reduced cardiorespiratory fitness and an elevated risk of cardiovascular disease. The mechanisms underlying this impairment are multifactorial, but the contribution of skeletal muscle fat infiltration has not been evaluated.
Nicholas J. Saner, Stephen J. Foulkes, Hayley T. Dillon, Lauren Burnham, Richard Thompson, Andre La Gerche, Mark J. Haykowsky, Erin J. Howden   +7 more
wiley   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Non‐Melanoma Skin Cancer in Transplant Recipients: A Single‐Centre Retrospective Cohort Study on the Role of Transplant Type, Immunosuppressive Exposure, and Tumor Subtypes

Clinical Transplantation, Volume 40, Issue 2, February 2026.
ABSTRACT Background Non‐melanoma skin cancer (NMSC) is a frequent long‐term complication in transplant recipients, mainly due to chronic immunosuppression. Its incidence varies by transplant type and regimen, but existing evidence is often fragmented.
Corrado Zengarini, Vittoria Tagnin, Gioia Sorbi, Alba Guglielmo, Michelangelo La Placa, Bianca Maria Piraccini, Alessandro Pileri, Marco Pignatti   +7 more
wiley   +1 more source

Polymeric organoiron compounds with carcinostatic properties (branched hydrazone linkers) [PDF]

, 2011
The insufficient efficaciousness of most currently used anticancer drugs has prompted worldwide efforts to reduce toxic and resistance effects, improve overall bioavailability, and widen the therapeutic window. A particularly promising technology to this
Nkazi, Bavon Diakanua
core  

Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT Autophagy is an intracellular recycling system that contributes to the maintenance of cellular homeostasis. However, by providing tolerance to various stressors, autophagy promotes the survival and proliferation of cancer cells and confers resistance to chemotherapy.
Satoshi Yano, Liangjing Xie, Jinjuan Li, Yuka Sugaya, Yuki Miyauchi, Shigeru Kabayama, Taichi Hara   +6 more
wiley   +1 more source

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]

, 2017
Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro, Di Cesare, Ernesto, Festuccia, Claudio, Fox, Judith A., Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mattei, Claudia, Rossi, Giulia, Ventura, Luca, Vetuschi, Antonella, Vitale, Flora   +11 more
core   +1 more source

Cytotoxic and Antileishmanial Potential of Pilocarpus microphyllus Essential Oil: In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Jaborandi (Pilocarpus microphyllus) essential oil is obtained by removal and characterization using GC‐MS, revealing γ‐cadinene and trans‐caryophyllene as major constituents. The oil exhibits biological activity, with antifungal action against Candida spp.
Juniel Cruz Silva, Maria Gabriela Araújo Mendes, Paulo Sérgio de Araujo Sousa, Alyne Rodrigues de Araújo Nobre, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Tatiane Caroline Daboit, José de Sousa Lima Neto, Ygor Victor Ferreira Pinheiro, Ytallo da Costa Sousa, Edymilaís da Silva Sousa, José Delano Barreto Marinho Filho, Ana Jérsia Araújo, Francisco Artur Silva Filho, Sidney Gonçalo de Lima, Leiz Maria Costa Véras   +15 more
wiley   +1 more source