Results 41 to 50 of about 7,490 (132)
Clinical Case Reports, Volume 14, Issue 1, January 2026.Transthoracic echocardiography demonstrating biventricular dilatation. Parasternal long‐ and short‐axis views and apical four‐ and two‐chamber views show marked left ventricular dilatation with increased end‐diastolic volume, associated with right ventricular dilatation.
Cristian Orlando Porras Bueno +3 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 2, January 2026.Natural products and/or their structural analogs represent the greatest number of approved small‐molecules as antitumor agents. We report the synthesis of 2‐propanamide and 2‐propanamine dihydrobenzopyrans and 2‐ and 2,3‐disubstituted quinolines to evaluate their cytotoxicity against human A549 (lung), A2058 (melanoma), HepG2 (liver), MCF‐7 (breast ...
Bernabeu‐Sanchis Álvaro +8 more
wiley +1 more source
Procjena cito-/genotoksičnosti irinotekana u V79-stanicama primjenom komet-testa, mikronukleus-testa i testa kromosomskih aberacija [PDF]
, 2010 Irinotecan is a topoisomerase I interactive agent, widely used in the treatment of metastatic colorectal cancer. The genotoxic effects of the maximum single dose (18 μg mL-1), recommended monotherapy dose (9 μg mL-1), and recommended combined therapy ...
A. Mahabir +36 more
core +2 more sources
Particle &Particle Systems Characterization, Volume 43, Issue 1, January 2026.The present study developed and characterized a novel copaiba oil polymeric nanoparticle (NPOC), which was efficiently internalized by breast cancer cells, exhibited greater cytotoxicity and selectivity than free copaiba oil and standard drug doxorubicin. NPOC also reduced tumor growth and migration in 3D models.
Karinne Kelly Gadelha Marques +10 more
wiley +1 more source
Polymeric organoiron compounds with carcinostatic properties (branched hydrazone linkers) [PDF]
, 2011 The insufficient efficaciousness of most currently used anticancer drugs has prompted worldwide efforts to reduce toxic and resistance effects, improve overall bioavailability, and widen the therapeutic window. A particularly promising technology to this
Nkazi, Bavon Diakanua
core
European Journal of Heart Failure, Volume 27, Issue 12, Page 2671-2690, December 2025.Main categories of harmful drugs in heart failure. CCB, calcium channel blocker; DPP4i, dipeptidyl peptidase‐4 inhibitor; HER2‐TT, human epidermal growth factor receptor 2‐targeted therapy; NSAID, non‐steroidal anti‐inflammatory drug; TKI, tyrosine kinase inhibitor; TZD, thiazolidinedione; VEGF Inh, vascular endothelial growth factor inhibitor.
Amr Abdin +16 more
wiley +1 more source
Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]
, 2017 Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro +11 more
core +1 more source
Immunity, Inflammation and Disease, Volume 13, Issue 12, December 2025.Our findings indicate that Cordyceps Sinensis (CS) alleviates COPD symptoms by inhibiting inflammation and oxidative stress, with key biomarkers such as interleukins (ILs), tumor necrosis factor (TNF), and reactive oxygen species (ROS) identified. Activating autophagy serves as a protective mechanism against COPD development induced by oxidative stress.
Zirui Zang, Yuhan Kong, Qi Kong
wiley +1 more source
Antibiotic Resistance Crisis: From Bacterial Bioprospecting to Artificial Intelligence
Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.Overview of the global antimicrobial resistance crisis and interdisciplinary approaches to address it, including bioprospecting, innovative cultivation strategies, genomics and bioinformatics, artificial intelligence and machine learning, alternative antimicrobial therapies, and educational strategies.
I. C. Cunha‐Ferreira +3 more
wiley +1 more source
Using a 3-d model system to screen for drugs effective on solid tumors [PDF]
, 2011 There is a large medical need for the development of effective anticancer agents with minimal side effects. The present thesis represents an attempt to identify potent drugs for treatment of solid tumors.
Fayad, Walid
core +1 more source