Results 51 to 60 of about 16,625 (206)

Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis

Türk Oftalmoloji Dergisi, 2016
Pediatric uveitis may be a serious health problem because of the lifetime burden of vision loss due to severe complications if the problem is not adequately treated.
İlknur Tuğal-Tutkun
doaj   +1 more source

Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress

Molecules, 2020
Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU).
Lázaro de Sousa Fideles, João Antônio Leal de Miranda, Conceição da Silva Martins, Maria Lucianny Lima Barbosa, Helder Bindá Pimenta, Paulo Vitor de Souza Pimentel, Claudio Silva Teixeira, Marina Alves Sampaio Scafuri, Samuel de Osterno Façanha, João Erivan Façanha Barreto, Poliana Moreira de Medeiros Carvalho, Ariel Gustavo Scafuri, Joabe Lima Araújo, Jefferson Almeida Rocha, Icaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Matheus da Silva Campelo, Maria Elenir Nobre Pinho Ribeiro, Gerly Anne de Castro Brito, Gilberto Santos Cerqueira   +19 more
doaj   +1 more source

Prevention of corneal complications after post-operative application of antimetabolites following non-penetrating deep sclerectomy

Офтальмохирургия
Purpose. To evaluate the clinical and functional effectiveness of the developed method for prevention of corneal complications of non-penetrating deep sclerectomy (NPDS) with postoperative adjuvant use of 5-fluorouracil in comparison with the control ...
S.N. Svetozarskii, A.N. Andreev, A.V. Shvaikin, S.V. Scherbakova   +3 more
doaj   +1 more source

The investigation of antinutritional factors in Phaseolus vulgaris. Environmental and varietal differences [PDF]

Biotechnologie, Agronomie, Société et Environnement, 1999
This study enables us to indicate that the oligosaccharide raffinose family, phytate, saponin and lectin contents of P. vulgaris are clearly influenced by both environmental and genetics factors.
Burbano C., Muzquiz M., Ayet G., Pedrosa M.M., Cuadrado C.   +4 more
doaj  

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

The first investigation on differences in the effectiveness of mycophenolate mofetil and azathioprine antimetabolites determined in Polish patients treated for non-infectious uveitis

Annals of Agricultural and Environmental Medicine, 2020
Introduction The non-infectious uveitis, a serious vision-threatening disease is the fourth most common cause of blindness in working population of the developed world.
Maja Waszczyk-Łączak, Monika Łazicka-Gałecka, Lidia Chomicz, Krzysztof Mucha, Leszek Pączek, Jacek P. Szaflik   +5 more
doaj   +1 more source

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Outcome of trabeculectomies without adjunctive antimetabolites

, 2006
Background: The effectiveness of trabeculectomy in the management of glaucoma is well known. It is the most common intervention for most glaucoma cases treated in the Upper East region.
Debrah, OA, Abugri, P, Awini, EA, EA Awini, P Abugri, ME Gyasi, WMK Amoaku, Amoaku, WMK, OA Debrah, Gyasi, ME   +9 more
core   +1 more source

Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation [PDF]

, 1994
Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after ...
Todo, S, Irish, W, Miyazawa, H, Fujisaki, S, Starzl, TE, Tanabe, M, Murase, N   +6 more
core   +1 more source

Photochemical Internalization Using Natural Anticancer Drugs, Antimetabolites, and Nanoformulations: A Systematic Study against Breast and Pancreatic Cancer Cell Lines

, 2023
Photochemical internalization (PCI) is a novel, minimally invasive drug delivery technology that facilitates the delivery of therapeutic molecules into the cytosol of cells.
Alexandra Iliopoulou (14651440), George Pasparakis (2423818), Christopher Barnett (3498812), Fanny Joubert (1463020), Raúl Sánchez Álvarez (14651443)   +4 more
core   +1 more source