Results 111 to 120 of about 16,575 (212)

A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation

open access: yes, 2019
The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan ...
Elena Yu. Andryukhina, Liliya K. Shpigun
core   +1 more source

Nucleoside and nucleotide analogues containing fluorine [PDF]

open access: yes, 1993
The work contained in this thesis is divided into four sections detailing the formation of (diethoxyphosphinyl)difluoromethylene substituted cycloalkanes and alkenes and their chemistry, as well as the syntheses of purine and pyrimidine substituted ...
Parkinson, Nigel Christopher
core  

Abstract 3069: The S-phase checkpoint function of MGMT provides an unexpected rational route to profoundly increase the efficacy of anticancer antimetabolites in cell culture and xenograft models

open access: yes, 2017
MGMT is an anti-mutagenic DNA repair protein highly expressed not only in brain tumors, but also breast cancers, melanoma and colon cancers, and confers drug resistance.
AGM Mostofa   +4 more
core   +1 more source

REPRODUCTION CONTROL OF DACUS OLEAE USING ANTIMETABOLITES

open access: yes, 1996
ΤΑ ΑΝΑΛΟΓΑ ΑΜΙΝΟΞΕΩΝ ΕΙΝΑΙ ΟΥΣΙΕΣ (ΦΥΣΙΚΕΣ Η ΣΥΝΘΕΤΙΚΕΣ) ΜΕ ΠΑΡΟΜΟΙΑ ΧΗΜΙΚΗ ΔΟΜΗ ΚΑΙ ΔΡΑΣΗ ΜΕ ΤΑ ΚΑΝΟΝΙΚΑ ΑΜΙΝΟΞΕΑ ΤΑ ΟΠΟΙΑ ΚΑΙ ΑΝΤΑΓΩΝΙΖΟΝΤΑΙ, ΕΜΠΟΔΙΖΟΝΤΑΣΤΟ ΜΕΤΑΒΟΛΙΣΜΟ ΤΟΥΣ ΚΑΙ ΠΡΟΚΑΛΩΝΤΑΣ ΣΥΝΗΘΩΣ ΑΡΝΗΤΙΚΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΣΤΗ ΦΥΣΙΟΛΟΓΙΑ ΤΩΝ ΟΡΓΑΝΙΣΜΩΝ.
Ζωγράφου, Ελένη
core   +1 more source

Late onset of sequential multifocal bleb leaks after filtration surgery with antimetabolites (5-fluorouracil and mitomycin C)

open access: yes, 1996
Purpose. Antimetabolites increase the success of filtration surgery but also increase the post-operative complications. We describe the late onset of sequential multifocal bleb leaks as a previously unreported postoperative complication after filtering ...
Belyea, D. A.   +4 more
core  

ANTIMETABOLITES OF SEROTONIN

open access: yesJournal of Biological Chemistry, 1953
D W, WOOLLEY, E, SHAW
openaire   +2 more sources

Antimetabolites in the treatment of arthritis:current status of the use of antimetabolites

open access: yesNucleosides, nucleotides & nucleic acids, 2004
Rheumatoid arthritis (RA) is an autoimmune disease characterized by a chronic inflammation of the synovial joints and infiltration of blood-derived cells. In daily practice rheumatologists use the antimetabolites methotrexate (MTX) and leflunomide for the treatment of patients with rheumatoid arthritis.
Dijkmans, B A C, Jansen, G
openaire   +2 more sources

A rational approach to chemotherapy : the history of antimetabolites (1935-1955)

open access: yes, 2016
En 1940, le biochimiste anglais Donald Woods propose une explication du mode d'action des nouveaux sulfamides antibactériens : l'inhibition compétitive. Son collègue Paul Fildes fonde sur cette base une nouvelle approche de la chimiothérapie, revendiquée
Serviant-Fine, Thibaut
core  

Studies on microbial protein synthesis with Azotobacter vinelandii as the test organism I. Incorporation of radioactive phosphate and sulfate into the resting cells in the presence of antibiotics and antimetabolites

open access: yes, 1962
The effects of the three antibiotics, chloramphenicol, streptomycin and penicillin and two antimetabolites, p-fluorophenylalanine and 8-azaguanine, on the synthesis of nucleic acid and protein in Azotobacter vinelandii were investigated by studying the ...
Burma, D. P., Chakravorty, Maharani
core   +1 more source

Sequential versus Combined Glaucoma and Cataract Procedures in Siriraj Hospital

open access: yesSiriraj Medical Journal, 2006
Objective: To compare the efficacy of intraocular pressure (IOP) control after combined cataract and trabeculectomy with sequential cataract surgery after trabeculectomy, both with and without antimetabolites.
Darin Sakiyalak   +2 more
doaj  

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