Results 61 to 70 of about 15,196 (172)

Removal of antinutritional factors from bean (Phaseolus vulgaris L.) seeds [PDF]

Biotechnologie, Agronomie, Société et Environnement, 1999
Phytohemagglutinin and the lectin-related proteins present in bean seeds are toxic to monogastric animals and lower the nutritional value of beans. Since these antimetabolites are present in substantial amounts, a breeding program aimed to the removal ...
Bollini R., Carnovale E., Campion B.
doaj  

Early Onset Bacteremia in Kidney Transplant Recipients in the Current Era

Transplant Infectious Disease, EarlyView.
ABSTRACT Background Bloodstream infection (BSI) after kidney transplantation increases the risk of graft loss and mortality. We aimed to identify contemporary risk factors and outcomes of early BSI (eBSI) at our transplant center. Methods We conducted a retrospective chart review of adult kidney transplant recipients (KTRs) from 2019 to 2023.
Lana Hasan, Nabin K. Shrestha, Mathew Duck, Joshua Augustine, Richard Fatica, Alvin Wee, Christine E. Koval   +6 more
wiley   +1 more source

Variabilidad fitoquímica y repercusión antinutricional potencial en especies del género Albizia Phytochemical variability and potential antinutritional repercussion in species of the Albizia genus

Pastos y Forrajes, 2007
Mediante los análisis de componentes principales (ACP), clasificación automática (ACA) y varianza simple (ANOVA), se estudió el espectro de variaciones de la composición química de once especies del género Albizia (A. berteriana, A. caribaea, A.
D.E García, María Gabriela Medina, F Ojeda, J Humbría, C Domínguez, A Baldizán, Odalys Toral   +6 more
doaj  

Pseudophakic macular edema in a steroid responder treated successfully with intravitreal methotrexate: A case report

Indian Journal of Ophthalmology. Case Reports
Pseudophakic macular edema (PME) is typically treated with nonsteroidal anti-inflammatory drugs (NSAIDs) initially, followed by steroids. Treatment with steroids becomes challenging in steroid responders. We report a case of PME treated with intravitreal
Simran, Suresh Ramchandani, Shubhangi Mahesh, Fatema Lokhandwala   +3 more
doaj   +1 more source

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Combined inhibition of de novo pyrimidine synthesis and ATR promotes ATF4‐mediated cell death in TP53‐deficient ALL

HemaSphere, Volume 10, Issue 7, July 2026.
Abstract Mutations or deletions affecting the TP53 gene predict a dismal outcome in relapsed acute lymphoblastic leukemia (ALL). Loss of p53 function compromises the response to many anti‐leukemic therapies, underscoring the need for agents that are effective in TP53‐deficient cells.
Kari J. T. Grünewald, Marjolein M. G. Kes, Gawin R. Stoll, Willem P. J. Cox, Dorette S. van Ingen Schenau, Enzo M. Scutigliani, Emmely M. Wagener, Ziqin Tang, Senna Visser, Jolanda Kooiman, Jessica Buijs‐Gladdines, Maria Rodionova, Esther A. Zaal, Jeroen W. A. Jansen, Jeroen F. van Velzen, Jarno Drost, Laurens T. van der Meer, Celia R. Berkers, Frank N. van Leeuwen   +18 more
wiley   +1 more source

Leftover mitomycin-c sponge causing blebitis

Indian Journal of Ophthalmology, 2019
Trabeculectomy is the commonest surgical intervention performed worldwide for the treatment of open-angle glaucoma. However, the use of antimetabolites during trabeculectomy has been associated with various bleb related complications.
Mayuri Khamar, Deepak Bhojwani, Priyanka Patel, Abhay Vasavada   +3 more
doaj   +1 more source

Breakthrough reactions in pediatric chemotherapeutic desensitization: Outcomes and associated risk factors

Pediatric Allergy and Immunology, Volume 37, Issue 7, July 2026.
Breakthrough reactions in Pediatric chemotherapeutic desensitization: outcomes and associated risk factors. Abstract Background Rapid drug desensitization (RDD) enables the safe reintroduction of chemotherapeutic agents in patients with hypersensitivity reactions (HSRs).
Pathitta Doradee, Supaluk Tangvalelerd, Kantima Kanchanapoomi, Prapasri Kulalert, Punchama Pacharn, Orathai Jirapongsananuruk, Witchaya Srisuwatchari   +6 more
wiley   +1 more source