Results 71 to 80 of about 15,247 (179)

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Khalid J.H. Alzahrani, Juma A.M. Ali, Anthonius A. Eze, Wan Limm Looi, Daniel N.A. Tagoe, Darren J. Creek, Michael P. Barrett, Harry P. de Koning   +7 more
doaj   +1 more source

Work‐Influenced Circadian Disruption Connected to Disease Risk but Not Microbiomes in a Cohort of Philadelphia Nurses

American Journal of Human Biology, Volume 38, Issue 8, August 2026.
ABSTRACT Objectives Circadian rhythms influence activity cycles in humans, and circadian rhythm disruption (CRD) can negatively impact cardiometabolic disease risk and microbiome composition. This study documented CRD in a sample of nurses in Philadelphia, examining connections between CRD, disease risk, and work environment factors, proposing the ...
Clare Super, Maira Asif, Charlene Compher, Theodore G. Schurr, Morgan K. Hoke   +4 more
wiley   +1 more source

Secondary Hemophagocytic Lymphohistiocytosis Complicated by Mucormycosis Following Liver Transplantation for Cryptogenic Acute Liver Failure: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT HLH must be suspected in liver transplant patients who exhibit fever, cytopenia, hyperferritinemia, and dysfunction of the graft. HLH‐2004 guidelines and H‐score assessment early on will aid in early diagnosis and management, although prognosis remains poor when there are opportunistic infections.
Saif Ali Malik, Muhammad Hassaan Javaid, Syed Sibt E Haider, Hajirah Ghairat, AbuBakar Hafeez Bhatti, Hasibullah Aminpoor   +5 more
wiley   +1 more source

Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions

Molecular & Cellular Oncology, 2018
Specific metabolic alterations have recently been observed in cisplatin-resistant cancers. As a result, cisplatin resistance can be overcome by co-administration of pyridoxine, and cisplatin-resistant cancer cells become exquisitely sensitive to killing ...
Maria Castedo, Florine Obrist, Guido Kroemer   +2 more
doaj   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Case series of subconjunctival Inj mitomycin C with bleb massage in postoperative period of mitomycin C augmented trabeculectomies for bleb modulation

Indian Journal of Ophthalmology. Case Reports
We report four cases of use of Inj mitomycin C (MMC) (20 mcg) in the subconjunctival space adjacent to bleb of MMC augmented trabeculectomies, followed by bleb massage regimen.
Anukool S Deshpande, Sushama N Rahate
doaj   +1 more source

Apigenin, Selenium, and Combinations Are Effective in Preventing 5‐Fluorouracil Induced Cardiovascular Damage

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
5‐Fluorouracil (5‐FU) induces cardiovascular toxicity by increasing ROS, MDA, Bax, and caspase‐3 while decreasing antioxidant defenses and Bcl‐2 levels. Apigenin and selenium enhance antioxidant capacity, restore Bcl‐2 expression, suppress apoptosis, and rebalance redox status.
Gözde Atila Uslu, Hamit Uslu, Taha Abdulkadir Çoban, Emine Toraman, Mustafa Özkaraca   +4 more
wiley   +1 more source

De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi, Alastair G. McEwan, Ulrike Kappler   +2 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Unveiling the New Trick for Epigenetic Drug: Radiation Enhancement of Prostate Cancer by the EZH2 Inhibitor Tazemetostat

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT The enhancer of zeste homologue 2 inhibitor (EZH2i) Tazemetostat (EPZ‐6438) has demonstrated antitumour efficacy in various malignancies. This study aims to evaluate its radiosensitising potential and underlying mechanisms in prostate cancer (PCa). In vitro functional assays, including wound healing, Transwell invasion, EdU proliferation, flow
Tian‐Qi Du, Yuhong Ou, Rui‐Ji Liu, Yi Feng, Yaxun Li, Gang Chen, Xingyu Wu   +6 more
wiley   +1 more source