Results 71 to 80 of about 16,575 (212)

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites [PDF]

, 2020
Stress response pathways are critical for cellular homeostasis, promoting survival through adaptive changes in gene expression and metabolism. They play key roles in numerous diseases and are implicated in cancer progression and chemoresistance. However,
Anna Bichler, Jan Medenbach, Seifert, Nicole, Toedt, Grischa, Steltgens, Sascha, Moritz Freyberg, Stefan Reich, Björn Tews, Robert Ahrends, Knobbe-Thomsen, Christiane B., Cristina Coman, Nicole Seifert, Dominik Conrad, Bichler, Anna, Reich, Stefan, Conrad, Dominik, Himanshu Soni, Chi D. L. Nguyen, Has, Canan, Soni, Himanshu, Coman, Cristina, Sascha Steltgens, Nguyen, Chi D. L., Tews, Björn, Christiane B. Knobbe-Thomsen, Grischa Toedt, Freyberg, Moritz, Canan Has, Medenbach, Jan, Ahrends, Robert   +29 more
core   +1 more source

Incidence of Hepatitis B Virus Reactivation in Patients Treated With Immunosuppressive and Chemotherapeutic Agents

Alimentary Pharmacology &Therapeutics, EarlyView.
HBV reactivation incidence varied across immunosuppressive and chemotherapeutic agents. Clinically meaningful HBV reactivation was also observed in patients receiving corticosteroids and conventional immunosuppressive therapies. ABSTRACT Background Data on the incidence of hepatitis B virus reactivation (HBVr) remain limited. In Japan, patients who are
Kazuhiko Ikeuchi, Makoto Saito, Kazuya Okushin, Toshiyuki Kishida, Akira Kado, Kyoji Moriya, Kazuhiko Koike, Takeya Tsutsumi, Hiroshi Yotsuyanagi   +8 more
wiley   +1 more source

The Action of Antibiotics and Antimetabolites on the Tobacco Mosaic Virus Infection Process in Bean Leaves

, 1972
The action of 28 antibiotics and antimetabolites at varying concentrations was studied in coincidence with the bioassay of tobacco mosaic virus on detached bean leaves by using an ultrasonic method of inoculation developed by Lamborn, Cochran and ...
Nayyar, Virendra
core   +1 more source

Ischaemic stroke and 5‐fluorouracil or capecitabine: A systematic review and meta‐analysis of harms and a retrospective study of the WHO pharmacovigilance database

British Journal of Pharmacology, EarlyView.
Abstract Aim Fluoropyrimidines, including 5‐fluorouracil (5‐FU) and capecitabine, are cornerstone antineoplastic agents for cancer. Case reports suggest that these drugs may be associated with an under‐recognised risk of ischaemic stroke or transient ischaemic attack (TIA).
Sophie Nguyen, Ines Bentahrour, Camille Guerin, Charles Dolladille, Angélique Da Silva, François Cherifi, Elise‐Marie Minoc, Pierre‐Marie Morice, Nicolas Jacquin, Christophe Le Tourneau, Joachim Alexandre, Ahmad Nehme, Etienne Bastien   +12 more
wiley   +1 more source

Who Should Receive Antimetabolites After Filtering Surgery?

, 1992
Don't tell me what you think that I should do. What would you do if this were your patient?," and so go the questions about the use of antimetabolites with filtering surgery. In practice, many difficult and unresolved issues remain.
Richard K. Parrish, Parrish, Richard K
core   +1 more source

Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter [PDF]

, 2010
<b>Background</b>: Plasmodium parasites are unable to synthesize purines de novo and have to salvage them from the host. Due to this limitation in the parasite, purine transporters have been an area of focus in the search for anti-malarial ...
Neils B Quashie, Lisa C Ranford-Cartwright, Ranford-Cartwright Lisa C, Harry P De Koning, De Koning, H.P., de Koning Harry P, Quashie Neils B, Quashie, N.B., Ranford-Cartwright, L.C.   +8 more
core   +1 more source

Silver nanoparticles induce reactive oxygen species-mediated cell cycle delay and synergistic cytotoxicity with 3-bromopyruvate in Candida albicans, but not in Saccharomyces cerevisiae

International Journal of Nanomedicine, 2019
Bokyoung Lee,1,2 Mi Jin Lee,1 Su Jin Yun,1,2 Kyongmin Kim,1,2 In-Hong Choi,3 Sun Park1,21Department of Microbiology, Ajou University School of Medicine, Suwon, 442-749, Republic of Korea; 2Department of Biomedical Sciences, The Graduate School,
Lee B, Lee MJ, Yun SJ, Kim K, Choi IH, Park S   +5 more
doaj  

Bridging the Gap Between General and Transplant Infectious Disease Practice

Transplant Infectious Disease, EarlyView.
ABSTRACT The population of iatrogenic immunocompromised individuals is steadily rising as we continue to improve in our ability to manage diseases, including cancer, autoimmune disease, and end‐organ dysfunction, with increasing access to novel agents and transplantation.
Jeremey Walker, Emily Eichenberger, Steven Pergam, Maricar Malinis, Andrea J. Zimmer   +4 more
wiley   +1 more source

Short term experience with "modern" trabeculectomy augmented with intraoperative antimetabolites.

, 2005
PURPOSE: Owing to its technical refinements, "modern" trabeculectomy aims to reduce the incidence and severity of early postoperative complications while increasing postop IOP success. The purpose of our study was to evaluate namely the safety of "modern"
Detry-Morel, M., Pourjavan, S.
core  

Antimetabolites in the nutrition of the silkworm bombyx mori L.-I: niacin and pyridoxine antagonists

, 1958
Growth inhibition with antimetabolite and its reversal with the metabolite has been employed as a criterion for studying the nutritional requirement of the silkworm for niacin and pyridoxine.
Bhat, J. V., Shyamala, M. B.
core   +1 more source