Results 81 to 90 of about 16,575 (212)

Escape tardío de la bula de filtración a propósito de un caso Late onset of leaking filtering bleb in a case

Revista Cubana de Oftalmología, 2012
Paciente masculino de 48 años, de color de la piel mestizo, al que se le realizó trabeculectomía con antimetabolito en su ojo derecho con daño glaucomatoso avanzado y atrofia óptica glaucomatosa en su ojo izquierdo.
Yuderkys Díaz Águila, María Teresa Ferrer Guerra, Isabel Obret Mendive, Liamet Fernández Argones, Ibraín Piloto Díaz   +4 more
doaj  

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Synthesis of antimetabolites of sucrose

, 1994
The C-disaccharides D-glycero-D-ido-D-lyxo-7,11-anhydro-6-deoxydodec-5-ulofuranose-(5,2) 7a and D-glycero-D-ido-D-lyxo-7,11-anhydro-1-O-benzyloxysuccinyl-6-deoxydodec-5-ulofuranose-(5.2) 7b. antimetabolites of sucrose.
F. Nicotra, G. Russo, C. Pangrazio, L. Lay, L. Panza   +4 more
core   +1 more source

The clinical trial landscape of osteosarcoma: integrating trial data, immunotherapeutic trends, and biomarker insights

Frontiers in Immunology
Osteosarcoma, the most aggressive primary malignant bone tumor, has stagnant therapeutic outcomes despite decades of standard MAP chemotherapy and surgery; 5-year overall survival (OS) is <30% for metastatic/recurrent cases.
Lifeng Ge, Tianhao Xu, Xiaodong Gu, Xuekang Pan, Tian Gao, Huigen Lu   +5 more
doaj   +1 more source

Role of antimetabolites in recalcitrant idiopathic orbital inflammatory syndrome

Oman Journal of Ophthalmology, 2011
Background : High-dose systemic steroids are the primary modality of treatment for idiopathic orbital inflammatory syndrome (IOIS). Occasionally patients experience a relapse of symptoms on tapering steroids or require large doses of steroid ...
Yamini Priya, Suneetha Nithyanandam, Manjoo S Reddy   +2 more
doaj   +1 more source

Pegargiminase Suppresses the Fanconi Anemia Pathway and Promotes Melphalan‐Induced DNA Double‐Strand Breaks in Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
ADI‐PEG20 enhances melphalan‐induced DNA DSBs in UM cells. We describe potentiation of DNA DSBs in UM cell lines upon treatment with ADI‐PEG20 and melphalan (92.1 cells with STRIDE by intoDNA). ADI‐PEG20 suppresses multiple members of the FA pathway—a known resistance mechanism for melphalan—providing a rationale for exploring this drug combination in ...
Iuliia Pavlyk, George Field, Matthew Young, Josephine Carpentier, Emilia A. Szlosarek, Michaela R. O'Keeffe‐Brown, Timothy Crook, Nelofer Syed, John S. Bomalaski, Pui Ying Chan, Peter W. Szlosarek   +10 more
wiley   +1 more source

Association between Quality of Life and Visual Acuity in a Randomized Clinical Trial of Patients with Uveitis Taking Antimetabolites. [PDF]

PURPOSE: To evaluate how changes in visual acuity are associated with changes in quality of life (QoL) among patients with non-infectious uveitis taking antimetabolites.
Kanakath, Anuradha, Kelly, Nicole, Suhler, Eric, Doan, Thuy, Acharya, Nisha, Vedhanayaki, R, Chattopadhyay, Aheli, Thundikandy, Radhika, Al-Dhibi, Hassan, Rathinam, S, Lim, Lyndell, Ebert, Caleb, Porco, Travis, Gonzales, John, Murugan, S   +14 more
core   +1 more source

Removal of antinutritional factors from bean (Phaseolus vulgaris L.) seeds [PDF]

Biotechnologie, Agronomie, Société et Environnement, 1999
Phytohemagglutinin and the lectin-related proteins present in bean seeds are toxic to monogastric animals and lower the nutritional value of beans. Since these antimetabolites are present in substantial amounts, a breeding program aimed to the removal ...
Bollini R., Carnovale E., Campion B.
doaj  

Cumulative exposure to tacrolimus is associated with increased risk of malignancy for solid organ transplant recipients

International Journal of Cancer, Volume 158, Issue 12, Page 3152-3160, 15 June 2026.
What's new? Long‐term immunosuppression in solid organ transplant recipients (SOTRs) is linked to increased cancer risk. Although this risk potentially increases with greater immunosuppressant exposure, the exact dose‐response pattern remains uncertain.
Sergio A. Acuna, Xun Zhao, Maggie Jones‐Carr, Graham Smith, Kyla Naylor, Bima J. Hasjim, Shiyi Chen, An‐Wen Chan, Nancy Baxter, S. Joseph Kim, Mamatha Bhat   +10 more
wiley   +1 more source

Treatment and management of patients of both groups in the study after the bleb revision related to the need of antimetabolites and the time spent in hospital.

, 2016
Treatment and management of patients of both groups in the study after the bleb revision related to the need of antimetabolites and the time spent in hospital.
Norbert Pfeiffer (26543), Panagiotis Laspas (149587), Alicia Poplawksi (2836850), Franz Hermann Grus (2836844), Philipp David Culmann (2836838), Esther Maria Hoffmann (2836847), Verena Prokosch-Willing (2836841)   +6 more
core   +1 more source