Results 81 to 90 of about 17,951 (205)

Toxicity of Cytarabine Intravenous Constant Rate Infusion in Cats With Lymphoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Cytarabine intravenous constant rate infusion (IV CRI) toxicity in cats with lymphoma has not been well documented. We aimed to assess toxicities following cytarabine IV CRI as a single‐agent or within a multiagent protocol in cats with lymphoma. Medical records of cats with lymphoma treated with cytarabine IV CRI, with documented dose, route,
Rachel Hanford, Katherine A. Skorupski, Robert B. Rebhun, Rachel V. Brady, Sami Al‐Nadaf, Amandine T. Lejeune   +5 more
wiley   +1 more source

Single‐Cell Transcriptomic Identification of Drug‐Tolerant Persister Mechanisms in Capecitabine‐Treated Triple‐Negative Breast Cancer

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. This lack of receptors limits targeted therapies and contributes to high rates of recurrence.
Md Naiyem Islam, Md Kaziul Islam Sarkar Suja, Alif Al Takbir, Md. Kaderi Kibria   +3 more
wiley   +1 more source

The clinical trial landscape of osteosarcoma: integrating trial data, immunotherapeutic trends, and biomarker insights

Frontiers in Immunology
Osteosarcoma, the most aggressive primary malignant bone tumor, has stagnant therapeutic outcomes despite decades of standard MAP chemotherapy and surgery; 5-year overall survival (OS) is <30% for metastatic/recurrent cases.
Lifeng Ge, Tianhao Xu, Xiaodong Gu, Xuekang Pan, Tian Gao, Huigen Lu   +5 more
doaj   +1 more source

Role of antimetabolites in recalcitrant idiopathic orbital inflammatory syndrome

Oman Journal of Ophthalmology, 2011
Background : High-dose systemic steroids are the primary modality of treatment for idiopathic orbital inflammatory syndrome (IOIS). Occasionally patients experience a relapse of symptoms on tapering steroids or require large doses of steroid ...
Yamini Priya, Suneetha Nithyanandam, Manjoo S Reddy   +2 more
doaj   +1 more source

Efficacy and Safety of Apixaban Thromboprophylaxis According to Baseline Chemotherapy Class in High‐Risk Ambulatory Cancer Patients: A Post Hoc Analysis of the AVERT Trial

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in cancer patients. The AVERT trial showed apixaban thromboprophylaxis reduced VTE in intermediate‐to‐high‐risk patients initiating chemotherapy. However, the efficacy and safety of apixaban according to baseline chemotherapy class remain incompletely ...
Nadia Linxi Feng, John Doering, Tzu‐Fei Wang, Ranjeeta Mallick, Grégoire Le Gal, Joseph Shaw, Danny Hill, Sudeep Shivakumar, Vicky Tagalakis, Phil Wells, Marc Carrier   +10 more
wiley   +1 more source

Removal of antinutritional factors from bean (Phaseolus vulgaris L.) seeds [PDF]

Biotechnologie, Agronomie, Société et Environnement, 1999
Phytohemagglutinin and the lectin-related proteins present in bean seeds are toxic to monogastric animals and lower the nutritional value of beans. Since these antimetabolites are present in substantial amounts, a breeding program aimed to the removal ...
Bollini R., Carnovale E., Campion B.
doaj  

Short term experience with "modern" trabeculectomy augmented with intraoperative antimetabolites.

, 2005
PURPOSE: Owing to its technical refinements, "modern" trabeculectomy aims to reduce the incidence and severity of early postoperative complications while increasing postop IOP success. The purpose of our study was to evaluate namely the safety of "modern"
Detry-Morel, M., Pourjavan, S.
core  

Association between Quality of Life and Visual Acuity in a Randomized Clinical Trial of Patients with Uveitis Taking Antimetabolites. [PDF]

PURPOSE: To evaluate how changes in visual acuity are associated with changes in quality of life (QoL) among patients with non-infectious uveitis taking antimetabolites.
Kanakath, Anuradha, Kelly, Nicole, Suhler, Eric, Doan, Thuy, Acharya, Nisha, Vedhanayaki, R, Chattopadhyay, Aheli, Thundikandy, Radhika, Al-Dhibi, Hassan, Rathinam, S, Lim, Lyndell, Ebert, Caleb, Porco, Travis, Gonzales, John, Murugan, S   +14 more
core   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

Combination of Antimetabolites with Chemotherapy as a Novel Treatment Option in High-risk Neuroblastoma

, 2022
20 svenska barn diagnostiseras årligen med barntumören neuroblastom (NB). Läkemedelsresistens och intratumoral heterogenitet försvårar behandlingen och 50-60% av hög-risk NB-patienter drabbas av återfall.
Lundström, Maja
core   +2 more sources