Results 1 to 10 of about 210,775 (122)

Optimizing antimicrobial treatment schedules: some fundamental analytical results [PDF]

Bulletin of Mathematical Biology 86 (1), 2024, 2023
This work studies fundamental questions regarding the optimal design of antimicrobial treatment protocols, using standard pharmacodynamic and pharmacokinetic mathematical models. We consider the problem of designing an antimicrobial treatment schedule to achieve eradication of a microbial infection, while minimizing the area under the time ...
arxiv   +1 more source

Coupled environmental and demographic fluctuations shape the evolution of cooperative antimicrobial resistance [PDF]

J. R. Soc. Interface 20, 20230393 (2023), 2023
There is a pressing need to better understand how microbial populations respond to antimicrobial drugs, and to find mechanisms to possibly eradicate antimicrobial-resistant cells. The inactivation of antimicrobials by resistant microbes can often be viewed as a cooperative behavior leading to the coexistence of resistant and sensitive cells in large ...
arxiv   +1 more source

Molecular detection and antimicrobial activity of Endophytic fungi isolated from a medical plant Rosmarinus officinalis [PDF]

Vol 23, 2020, 14, 2023
Endophytes are tiny organisms present in living tissues of distinct plants and have been extensively studied for their endophytic microbial complement. Roots of Rosmarinus officinalis were subjected to the isolation of endophytic fungi and screened for antimicrobial activity against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram ...
arxiv   +1 more source

Polymeric ruthenium precursor as a photoactivated antimicrobial agent [PDF]

Journal of Hazardous Materials, 402, 2021, 123788, 2021
In this work, the antibacterial activity of the polymeric precursor dicarbonyldichlororuthenium has been studied against Escherichia coli and Staphylococcus aureus. This Ru carbonyl precursor shows minimum inhibitory concentration at nanogram per millilitre, which renders it a novel antimicrobial polymer without any organic ligands.
arxiv   +1 more source

Developing moral AI to support antimicrobial decision making [PDF]

, 2022
Artificial intelligence (AI) assisting with antimicrobial prescribing raises significant moral questions. Utilising ethical frameworks alongside AI-driven systems, while considering infection specific complexities, can support moral decision making to tackle antimicrobial resistance.
arxiv   +1 more source

A versatile multicomponent mesoporous silica nanosystem with dual antimicrobial and osteogenic effects [PDF]

Acta Biomaterialia 136 (2021) 570 to 581, 2021
In this manuscript, we propose a simple and versatile methodology to design nanosystems based on biocompatible and multicomponent mesoporous silica nanoparticles (MSNs) for infection management. This strategy relies on the combination of antibiotic molecules and antimicrobial metal ions into the same nanosystem, affording a significant improvement of ...
arxiv   +1 more source

Resist or perish: fate of a microbial population subjected to a periodic presence of antimicrobial [PDF]

PLoS Comput. Biol.16(4): e1007798 (2020), 2019
The evolution of antimicrobial resistance can be strongly affected by variations of antimicrobial concentration. Here, we study the impact of periodic alternations of absence and presence of antimicrobial on resistance evolution in a microbial population, using a stochastic model that includes variations of both population composition and size, and ...
arxiv   +1 more source

Mesoporous Silica Nanoparticles Decorated with Polycationic Dendrimers for Infection Treatment [PDF]

Acta Biomaterialia. 68, 261-271 (2018), 2021
This work aims to provide an effective and novel solution for the treatment of infection by using nanovehicles loaded with antibiotics capable of penetrating the bacterial wall, thus increasing the antimicrobial effectiveness. These nanosystems, named "nanoantibiotics", are composed of mesoporous silica nanoparticles (MSNs), which act as nanocarriers ...
arxiv   +1 more source

Small antimicrobial resistance proteins (SARPs): Small proteins conferring antimicrobial resistance [PDF]

arXiv, 2023
Small open reading frames are understudied as they have been historically excluded from genome annotations. However, evidence for the functional significance of small proteins in various cellular processes accumulates. Proteins with less than 70 residues can also confer resistance to antimicrobial compounds, including intracellularly-acting protein ...
arxiv  

Predicting antimicrobial drug consumption using web search data [PDF]

, 2018
Consumption of antimicrobial drugs, such as antibiotics, is linked with antimicrobial resistance. Surveillance of antimicrobial drug consumption is therefore an important element in dealing with antimicrobial resistance. Many countries lack sufficient surveillance systems.
arxiv   +1 more source