Results 31 to 40 of about 411,170 (267)

Unheard and Under‐Supported: Health‐Related Quality of Life in Children, Adolescents, and Young Adults With Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
Abstract Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia, Giulia Reggiani, Elizabeth J. Maran, Maria Elisa Delle Fave, Ilaria Baido, Anna Chiara Frigo, Maria Paola Boaro, Raffaella Colombatti   +7 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients

Virulence, 2019
Pneumonia is an infection of the lungs, where the alveoli in the affected area are filled with pus and fluid. Although ventilated patients are at risk, not all ventilated patients develop pneumonia.
Jolien Seinen, Willem Dieperink, Solomon A. Mekonnen, Paola Lisotto, Hermie J. M. Harmsen, Bart Hiemstra, Alewijn Ott, Daniel Schultz, Michael Lalk, Stefan Oswald, Sven Hammerschmidt, Anne Marie G. A. de Smet, Jan Maarten van Dijl   +12 more
doaj   +1 more source

Formulation and antimicrobial activity evaluation of a 0.2% chlorhexidine canine mouthwash with essential oils

Vitae, 2021
Background: Periodontal disease is the infection and inflammation of the gums, bones, and tissues involved in teeth support, and it is one of the most common diseases affecting pet dogs.
German Madrigal Redondo , Daniela Gonzalez Corrales , Marianela Chavarria Rojas , Tatiana Monge Quiros , Wendy Cruz Sibaja , Norman Rojas Campos   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Antimicrobial Activity of Isopteropodine

Zeitschrift für Naturforschung C, 2005
Bioassay-directed fractionation for the determination of antimicrobial activity of Uncaria tomentosa, has led to the isolation of isopteropodine (0.3%), a known Uncaria pentacyclic oxindol alkaloid that exhibited antibacterial activity against Gram positive bacteria.
García, Rubén, Cayunao, Cesia, Bocic, Ronny, Backhouse, Nadine, Delporte, Carla, Zaldivar, Mercedes, Erazo, Silvia   +6 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Antimicrobial resistance and antimicrobial activity of plant-based antimicrobial peptides against bacteria

Letters in Animal Biology
Antimicrobial peptides (AMPs) are a class of short, usually positively charged, polypeptides which are widely used to overcome the threat of the antimicrobial resistance. The potential of the AMPs is increasing as a new class of antibiotics.
Asif Ali, Silla Ambrose, Dilawar Hussain, Faisal Hafeez, Tayyaba Asghar, Syed Noraiz Arif Shah, Momina Ahsan, Muhammad Shakir, Arsam Ali, Arslan Muhammad Ali Khan, Muhammad Usama Javed   +10 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Antimicrobial Activity of Halogens

Journal of Food Protection, 1981
The bactericidal and sporicidal effects of halogens are reviewed. Chlorine and iodine are the halogens most widely used for inactivating microorganisms. Compounds containing chlorine and iodine are, in general, equally effective in destroying vegetative cells, but chlorine compounds are more effective in inactivating spores.
openaire   +2 more sources