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Cationic antimicrobial peptides: towards clinical applications
Expert Opinion on Investigational Drugs, 2000Cationic antimicrobial peptides are important components of the innate immune defences of all species of life. Variants of these natural molecules have a broad range of antibiotic, antifungal, antiviral and anti-endotoxic activity. Two of these cationic peptides have shown signs of efficacy in early clinical trials of oral mucositis and the ...
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Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP)
Journal of Medicinal Chemistry, 2017Teixobactin is a head to side chain cyclodepsipeptide that contains two positive charges. One is found in the cycle, as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other is at the N-terminal. Here we introduce 26 new Teixobactin analogues with an increasing number of positive charges.
Shimaa A. H. Abdel Monaim +4 more
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Are cationic antimicrobial peptides also ‘double-edged swords’?
Expert Review of Anti-infective Therapy, 2008The present view focuses on the possibility that cationic antimicrobial peptides (CAMPs) might, in addition to their killing effects due to permeabilization of microbial membranes, also function similarly to beta-lactam antibiotics to activate nascent autolytic wall enzymes, leading to bacteriolysis.
Isaac, Ginsburg, Erez, Koren
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Cationic Antimicrobial Peptides for Tuberculosis: A Mini-Review
Current Protein & Peptide Science, 2019Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms.
Sara, Silva, Nuno, Vale
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Novel Therapies Based on Cationic Antimicrobial Peptides
Current Pharmaceutical Biotechnology, 2006Cationic antimicrobial peptides serve as critical defense molecules protecting the host from invading bacteria, viruses and fungi. These antimicrobial peptides are widely distributed in nature and in vertebrates they have been localized to numerous tissues and cells.
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Russian Journal of Bioorganic Chemistry, 2018
Comparative antimicrobial properties of three artificial cationic synthetic antimicrobial peptides (SAMP): (RAhaR)4AhaβA (where R is Arg, Aha is 6-aminohexanoic acid, βA is beta-alanine), (KFF)3K and R9F2 with various amphiphilic properties have been studied relative to pathogenic strains of microorganisms: Gram-negative bacteria Pseudomonas aeruginosa,
N. V. Amirkhanov +2 more
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Comparative antimicrobial properties of three artificial cationic synthetic antimicrobial peptides (SAMP): (RAhaR)4AhaβA (where R is Arg, Aha is 6-aminohexanoic acid, βA is beta-alanine), (KFF)3K and R9F2 with various amphiphilic properties have been studied relative to pathogenic strains of microorganisms: Gram-negative bacteria Pseudomonas aeruginosa,
N. V. Amirkhanov +2 more
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Nanomechanical response of bacterial cells to cationic antimicrobial peptides
Soft Matter, 2014The effectiveness of antimicrobial compounds can be easily screened, however their mechanism of action is much more difficult to determine. Many compounds act by compromising the mechanical integrity of the bacterial cell envelope, and our study introduces an AFM-based creep deformation technique to evaluate changes in the time-dependent mechanical ...
Shun, Lu +3 more
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Immune modulation by multifaceted cationic host defense (antimicrobial) peptides
Nature Chemical Biology, 2013Cationic host defense (antimicrobial) peptides were originally studied for their direct antimicrobial activities. They have since been found to exhibit multifaceted immunomodulatory activities, including profound anti-infective and selective anti-inflammatory properties, as well as adjuvant and wound-healing activities in animal models.
Ashley L, Hilchie +2 more
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Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents
Biomaterials, 2011Antimicrobial peptides (AMPs) secreted by the innate immune system are prevalent as the effective first-line of defense to overcome recurring microbial invasions. They have been widely accepted as the blueprints for the development of new antimicrobial agents for the treatment of drug resistant infections.
Nikken, Wiradharma +5 more
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Cationic Amphiphilic Peptides: Synthetic Antimicrobial Agents Inspired by Nature
ChemMedChem, 2020AbstractAntimicrobial peptides are ubiquitous in multicellular organisms and have served as defense mechanisms for their successful evolution and throughout their life cycle. These peptides are short cationic amphiphilic polypeptides of fewer than 50 amino acids containing either a few disulfide‐linked cysteine residues with a characteristic β‐sheet ...
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