Results 121 to 130 of about 262,820 (287)

Lattice Structures for Bone Replacement: The Intersection of Bone Biomechanics, Lattice Design, and Additive Manufacturing

Advanced Materials Technologies, EarlyView.
This review outlines how understanding bone's biology, hierarchical architecture, and mechanical anisotropy informs the design of lattice structures that replicate bone morphology and mechanical behavior. Additive manufacturing enables the fabrication of orthopedic implants that incorporate such structures using a range of engineering materials ...
Stylianos Kechagias, Maxwell J. Munford, Frederik C.H. Masure, Richard J. van Arkel, Reece N Oosterbeek   +4 more
wiley   +1 more source

Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings

Antibiotics
Antimicrobial resistance is a critical global challenge in the 21st century, validating Sir Alexander Fleming’s warning about the misuse of antibiotics leading to resistant microbes.
Shyam Kumar Mishra, Tanzina Akter, Umme Laila Urmi, George Enninful, Manjulatha Sara, Jiawei Shen, Dittu Suresh, Liangjun Zheng, Elias Shiferaw Mekonen, Binod Rayamajhee, Francesco M. Labricciosa, Massimo Sartelli, Mark Willcox   +12 more
doaj   +1 more source

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

Hydrogel‐Based Functional Materials: Classifications, Properties, and Applications

Advanced Materials Technologies, EarlyView.
Conductive hydrogels have emerged as promising materials for smart wearable devices due to their outstanding flexibility, multifunctionality, and biocompatibility. This review systematically summarizes recent progress in their design strategies, focusing on monomer systems and conductive components, and highlights key multifunctional properties such as
Zeyu Zhang, Zao Cheng, Patrizio Raffa
wiley   +1 more source

Antimicrobial Peptides

, 2015
Antimicrobial peptides (AMPs) are gene-encoded, ancient (and important) mediators of innate host defense that exert direct or indirect antimicrobial action as well as possessing other important biologic activities (e.g., neutralization of endotoxin and anti-biofilm action) that help to protect vertebrates, invertebrates and plants from invading ...
  +5 more sources

C13 | Prototype antimicrobial peptide-based sanitiser: new horizons in the post-antibiotic era

Italian Journal of Food Safety
Purpose. The aim of this study was to develop a prototype of an environmentally friendly, effective and sustainable antimicrobial peptide-based disinfectant designed to reduce the persistence of pathogenic and spoilage bacteria throughout the dairy ...
ROSA LUISA AMBROSIO
doaj   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source