Results 41 to 50 of about 1,708,439 (147)

Synthetic antimicrobial peptides: Characteristics, design, and potential as alternative molecules to overcome microbial resistance.

Life Science, 2021
Recently, the dramatic emergence of antimicrobial resistance has received attention from World Health Organization. Synthetic antimicrobial peptides (SAMPs) are considered new weapons to fight against infections caused by multi-drug resistant pathogens ...
Patrícia G Lima, J. T. Oliveira, Jackson L. Amaral, C. D. Freitas, P. F. Souza   +4 more
semanticscholar   +1 more source

Antimicrobial Peptides in Reptiles

Pharmaceuticals, 2014
Reptiles are among the oldest known amniotes and are highly diverse in their morphology and ecological niches. These animals have an evolutionarily ancient innate-immune system that is of great interest to scientists trying to identify new and useful ...
Monique L. van Hoek
doaj   +1 more source

Enhanced antifouling properties of marine antimicrobial peptides by PEGylation

Frontiers in Bioengineering and Biotechnology, 2023
Covalent immobilisation of antimicrobial peptides (AMPs) on underwater surfaces to combat marine biofouling is of great interest as it is an efficient, broad-spectrum and environmentally friendly strategy.
Tong Lou, Xiuqin Bai, Xiuqin Bai, Xiaoyan He, Xiaoyan He, Wencheng Liu, Zongcheng Yang, Ying Yang, Chengqing Yuan   +8 more
doaj   +1 more source

Antimicrobial peptides: Opportunities and challenges in overcoming resistance.

Microbiology Research
Antibiotic resistance represents a global health threat, challenging the efficacy of traditional antimicrobial agents and necessitating innovative approaches to combat infectious diseases.
Cezara Bucataru, Corina Ciobanasu
semanticscholar   +1 more source

A Uniform In Vitro Efficacy Dataset to Guide Antimicrobial Peptide Design

Data, 2019
Antimicrobial peptides are ubiquitous molecules that form the innate immune system of organisms across all kingdoms of life. Despite their prevalence and early origins, they continue to remain potent natural antimicrobial agents.
Deepesh Nagarajan, Tushar Nagarajan, Neha Nanajkar, Nagasuma Chandra   +3 more
doaj   +1 more source

Rational Designed Hybrid Peptides Show up to a 6-Fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides Measured by BioSAXS

Frontiers in Pharmacology, 2021
Antimicrobial peptides (AMPs) are a promising class of compounds being developed against multi-drug resistant bacteria. Hybridization has been reported to increase antimicrobial activity. Here, two proline-rich peptides (consP1: VRKPPYLPRPRPRPL-CONH2 and
Kai Hilpert, Jurnorain Gani, Christoph Rumancev, Nathan Simpson, Paula Matilde Lopez-Perez, Vasil M. Garamus, Andreas Robert von Gundlach, Petar Markov, Marco Scocchi, Ralf Mikut, Axel Rosenhahn   +10 more
doaj   +1 more source

Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection

Journal of Nanobiotechnology
The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited their clinical application.
Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Yuanyuan Li, Ying Guo, Da Teng, Yinhua Huang, Jianhua Wang   +8 more
doaj   +1 more source

Development and Challenges of Antimicrobial Peptides for Therapeutic Applications

Antibiotics, 2020
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have been approved by the U.S. Food and Drug Administration (FDA). Now commercialized, these seven peptides have mostly been utilized for topical medications, though some ...
Charles H. Chen, T. Lu
semanticscholar   +1 more source

Waste to resource: Mining antimicrobial peptides in sludge from metagenomes using machine learning

Environment International
The emergence of antibiotic-resistant bacteria poses a huge threat to the treatment of infections. Antimicrobial peptides are a class of short peptides that widely exist in organisms and are considered as potential substitutes for traditional antibiotics.
Jiaqi Xu, Xin Xu, Yunhan Jiang, Yulong Fu, Chaofeng Shen   +4 more
doaj   +1 more source

A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides

International Journal of Molecular Sciences, 2020
Antimicrobial resistance is a multifaceted crisis, imposing a serious threat to global health. The traditional antibiotic pipeline has been exhausted, prompting research into alternate antimicrobial strategies.
K. Browne, Sudip Chakraborty, Renxun Chen, M. Willcox, David StClair Black, W. Walsh, N. Kumar   +6 more
semanticscholar   +1 more source