Results 111 to 120 of about 18,483 (237)

Candida Glabrata Fungaemia in a Tertiary Centre in Taiwan: Antifungal Susceptibility and Outcomes

, 2011
The proportion of non-albicans candidaemia has increased during recent decades, especially Candida glabrata. We evaluated the antifungal susceptibility, clinical features and outcome of C. glabrata fungaemia treated in a tertiary centre in Taiwan.
RUAN, SHENG-YUAN;HUANG, YU-TSUNG;CHU, CHEN-CHEN;YU, CHONG-JEN;HSUEH, PO-REN, 阮聖元;黃昱璁;朱蓁蓁;余忠仁;薛博仁   +1 more
core   +1 more source

Integrated Hydrophilic Interdigitated Network for Silicone Rubber via a Gradient Polarity Modification Strategy

Advanced Science, EarlyView.
This work overcomes the long‐standing challenge of hydrophilic modification of silicone rubber via a gradient polarity modification strategy. By constructing a hydrophilic interpenetrating network within cured SR, simultaneous surface‐to‐bulk modification is achieved while enabling monitoring through a Eu3+ complex fluorescent tracer.
Lihui Zhang, Rui Wang, Pingru Su, Yao Kou, Zhengfeng Ma, Hui Tang, Mingying Wang, Lixin Wang, Chunyu Zhou, Shuanhong Ma, Yu Tang, Feng Zhou   +11 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Neisseria gonorrhoeae antimicrobial susceptibility testing: application of traditional agar dilution to a high-throughput 96-well microtiter assay

Microbiology Spectrum
The global rise in Neisseria gonorrhoeae infections and increasing antimicrobial resistance underscores the urgent need for accessible and efficient antimicrobial susceptibility testing methods.
Joyce E. Kuipers, Laura Seidel, Nicole E. Garnier, Cezar M. Khursigara   +3 more
doaj   +1 more source

Rapid ultrasensitive detection platform for antimicrobial susceptibility testing.

PLoS Biology, 2019
Rapid detection and phenotyping of pathogenic microbes is critical for administration of effective antibiotic therapies and for impeding the spread of antibiotic resistance.
Mehmet F Cansizoglu, Yusuf Talha Tamer, Michael Farid, Andrew Y Koh, Erdal Toprak   +4 more
doaj   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Clinical performance of the VITEK REVEAL fast antimicrobial susceptibility test within a real-world workflow for gram-negative bacteremia: comparison with QMAC-dRAST and conventional methods

Microbiology Spectrum
Fast antimicrobial susceptibility testing (AST) is essential for appropriate antimicrobial therapeutic guidance in patients with bloodstream infections, reducing the time required for optimal treatment.
Junghun Park, Hae-Sun Chung, Mihwa Kim, Yohann Bala, Geehay Hong, Miae Lee, Min-Kyung So   +6 more
doaj   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Performance and hypothetical clinical impact of an mNGS-based machine learning model for antimicrobial susceptibility prediction of five ESKAPEE bacteria

Microbiology Spectrum
Antimicrobial resistance is an escalating global health crisis, underscoring the urgent need for timely and targeted therapies to ensure effective clinical treatment.
Yaoguang Li, Sizhen Liu, Peng Han, Jun Lei, Huifen Wang, Weiwei Zhu, Zihui Dong, Yize Zhang, Zhi Jiang, Beiwen Zheng, Guanhua Rao, Zujiang Yu, Ang Li   +12 more
doaj   +1 more source