Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation. [PDF]
PLoS Pathogens, 2010 The inability of sodium antimony gluconate (SAG)-unresponsive kala-azar patients to clear Leishmania donovani (LD) infection despite SAG therapy is partly due to an ill-defined immune-dysfunction.
Arun Kumar Haldar +8 more
doaj +10 more sources
Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters [PDF]
Antimicrobial Agents and Chemotherapy, 2002 ABSTRACT 2-(2″-Dichloroacetamidobenzyl)-3-(3′-indolylquinoline), designated indolylquinoline derivative A, reduced the splenic and the liver parasite burdens by >93.0% in Leishmania donovani -infected hamsters, whereas sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%.
Chiranjib Pal +9 more
semanticscholar +4 more sources
Annals of Hepato-Biliary-Pancreatic Surgery, 2021 Introduction Visceral leishmaniasis (VL) is a macrophage associated disorder which is linked with a profound decrease in the immunotherapeutic potential of the infected subjects leading to a marked reduction in the CD4 linked Th1 protective immune ...
Sukrat Sinha
semanticscholar +5 more sources
Combination Therapy Using Sodium Antimony Gluconate in Stearylamine-Bearing Liposomes against Established and ChronicLeishmania donovaniInfection in BALB/c Mice [PDF]
Antimicrobial Agents and Chemotherapy, 2004 ABSTRACTIn this work we report the activity seen with combination therapy using sodium antimony gluconate in liposomes composed of egg phosphatidyl choline and stearylamine for elimination ofLeishmania donovaniparasites from the liver and spleen of BALB/c mice with established and chronic infections.
Swati Pal, Rajesh Ravindran, Nahid Ali
semanticscholar +4 more sources
In Vitro Low Responsiveness of Leishmania donovani Towards Sodium Antimony Gluconate
Bangladesh Journal of Medical Microbiology, 2016 Kala-azar has been uprising concomitantly with drug-resistant strains of the causatinve agent, particularly in the neighbouring India. The actual perspective of drug resistance in Leishmania donovani in Bangladesh is yet to be explored. So, this prospective study, as a preliminary one, was done to observe in vitro drug responsiveness against Sodium ...
Murshed Alam +7 more
semanticscholar +4 more sources
In Vitro Susceptibility of Field Isolates of Leishmania donovani to Miltefosine and Amphotericin B: Correlation with Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity [PDF]
Antimicrobial Agents and Chemotherapy, 2008 ABSTRACT Indian Leishmania donovani isolates ( n = 19) from regional zones representing various levels of antimony resistance displayed significantly ( P < 0.01) correlated results with respect to in vitro susceptibility to the antileishmanial drugs sodium
Dhiraj Kumar +3 more
semanticscholar +4 more sources
Proteome mapping of overexpressed membrane‐enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani [PDF]
British Journal of Clinical Pharmacology, 2010 WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Over 60% of patients with visceral leishmaniasis (VL) in India and Sudan have become unresponsive to treatment with pentavalent antimonials, the first line of drugs for over 60 years. The drug resistance mechanism, studied so far in in vitro selected laboratory strains, has been attributed to various ...
Awanish Kumar +5 more
semanticscholar +5 more sources
Journal of Medicine, 1970 A total of fifty consecutive cases of Kala-azar admitted in the medicine units of Rajshahi Medical College Hospital during the period from February 2006 to October 2006 were included in this study.
Quazi Tarikul Islam +5 more
semanticscholar +4 more sources
Sodium Antimony Gluconate leads to a predominant protective response during Visceral Leishmaniasis on triggering CD2 epitope [PDF]
International Journal of Infectious Diseases, 2018 Siddhartha Sinha, Shanthy Sundaram
semanticscholar +3 more sources
Antimony susceptible Leishmania donovani: evidence from in vitro drug susceptibility of parasites isolated from patients of post-kala-azar dermal leishmaniasis in pre- and post-miltefosine era [PDF]
Microbiology SpectrumPost-kala-azar dermal leishmaniasis (PKDL) patients are a key source of Leishmania donovani parasites, hindering the goal of eliminating visceral leishmaniasis (VL). Monitoring treatment response and parasite susceptibility is essential due to increasing
Sushmita Ghosh +6 more
doaj +2 more sources