Results 1 to 10 of about 1,650 (197)

RETRACTED: Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation. [PDF]

PLoS Pathogens, 2010
The inability of sodium antimony gluconate (SAG)-unresponsive kala-azar patients to clear Leishmania donovani (LD) infection despite SAG therapy is partly due to an ill-defined immune-dysfunction.
Arun Kumar Haldar, Vinod Yadav, Eshu Singhal, Kamlesh Kumar Bisht, Alpana Singh, Suniti Bhaumik, Rajatava Basu, Pradip Sen, Syamal Roy   +8 more
doaj   +8 more sources

Retraction: Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation [PDF]

PLoS Pathogens
PLOS Pathogens Editors
doaj   +4 more sources

Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters [PDF]

Antimicrobial Agents and Chemotherapy, 2002
ABSTRACT 2-(2″-Dichloroacetamidobenzyl)-3-(3′-indolylquinoline), designated indolylquinoline derivative A, reduced the splenic and the liver parasite burdens by >93.0% in Leishmania donovani -infected hamsters, whereas sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%.
Chiranjib, Pal, Mousumi, Raha, Anirban, Basu, Keshab Chandra, Roy, Anasuya, Gupta, Monidipa, Ghosh, Niranjan Prasad, Sahu, Sukdeb, Banerjee, Nirup Bikash, Mandal, Santu, Bandyopadhyay   +9 more
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In Vitro Low Responsiveness of Leishmania donovani Towards Sodium Antimony Gluconate

Bangladesh Journal of Medical Microbiology, 2016
Kala-azar has been uprising concomitantly with drug-resistant strains of the causatinve agent, particularly in the neighbouring India. The actual perspective of drug resistance in Leishmania donovani in Bangladesh is yet to be explored. So, this prospective study, as a preliminary one, was done to observe in vitro drug responsiveness against Sodium ...
Abdullah Akhtar Ahmed, Md. Akram Hossain, Mesbah Uddin Ahmed, Md Chand Mahmud, Abul Hossain Khan, AKM Musa, AKM Shamsuzzaman, Murshed Alam   +7 more
openaire   +3 more sources

Antimony susceptible Leishmania donovani: evidence from in vitro drug susceptibility of parasites isolated from patients of post-kala-azar dermal leishmaniasis in pre- and post-miltefosine era [PDF]

Microbiology Spectrum
Post-kala-azar dermal leishmaniasis (PKDL) patients are a key source of Leishmania donovani parasites, hindering the goal of eliminating visceral leishmaniasis (VL). Monitoring treatment response and parasite susceptibility is essential due to increasing
Sushmita Ghosh, Aditya Verma, Dhiraj Kumar, Deepak Kumar Deep, V. Ramesh, Poonam Salotra, Ruchi Singh   +6 more
doaj   +2 more sources

Bronchoalveolar Lavage Fluid Metagenomic Second-Generation Sequencing Assists in Guiding the Treatment of Visceral Leishmaniasis: A Case Report [PDF]

Infection and Drug Resistance
Jian Li,1,* Li Liu,2,* Zhiyun Gao,1 Xia Chuai,3 Xiaokun Liu,4 Xiaobo Zhang,2 Xinyu Zhang,2 Xiaoqing Su,2 Qian Xu,2 Zhuojun Deng2 1Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China ...
Li J, Liu L, Gao Z, Chuai X, Liu X, Zhang X, Zhang X, Su X, Xu Q, Deng Z   +9 more
doaj   +2 more sources

Comprehensive economic evaluation of thermotherapy for the treatment of cutaneous leishmaniasis in Colombia [PDF]

BMC Public Health, 2018
Background Cutaneous leishmaniasis causes a high disease burden in Colombia, and available treatments present systemic toxicity, low patient compliance, contraindications, and high costs.
Jaiberth Antonio Cardona-Arias, Liliana López-Carvajal, Mery Patricia Tamayo-Plata, Iván Darío Vélez   +3 more
doaj   +3 more sources

Combination Therapy Using Sodium Antimony Gluconate in Stearylamine-Bearing Liposomes against Established and ChronicLeishmania donovaniInfection in BALB/c Mice [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACTIn this work we report the activity seen with combination therapy using sodium antimony gluconate in liposomes composed of egg phosphatidyl choline and stearylamine for elimination ofLeishmania donovaniparasites from the liver and spleen of BALB/c mice with established and chronic infections.
Swati, Pal, Rajesh, Ravindran, Nahid, Ali   +2 more
openaire   +3 more sources

Proteome mapping of overexpressed membrane‐enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani [PDF]

British Journal of Clinical Pharmacology, 2010
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Over 60% of patients with visceral leishmaniasis (VL) in India and Sudan have become unresponsive to treatment with pentavalent antimonials, the first line of drugs for over 60 years. The drug resistance mechanism, studied so far in in vitro selected laboratory strains, has been attributed to various ...
Awanish, Kumar, Brijesh, Sisodia, Pragya, Misra, Shyam, Sundar, Ajit Kumar, Shasany, Anuradha, Dube   +5 more
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Skewing of Sodium Antimony Gluconate mediated therapy for a predominant Th1 during visceral leishmaniasis on triggering CD2 epitope to circumvent liver infection

Annals of Hepato-Biliary-Pancreatic Surgery, 2021
Introduction Visceral leishmaniasis (VL) is a macrophage associated disorder which is linked with a profound decrease in the immunotherapeutic potential of the infected subjects leading to a marked reduction in the CD4 linked Th1 protective immune response.
Sukrat Sinha
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