Results 1 to 10 of about 5,997 (174)

Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation.

PLoS Pathogens, 2010
The inability of sodium antimony gluconate (SAG)-unresponsive kala-azar patients to clear Leishmania donovani (LD) infection despite SAG therapy is partly due to an ill-defined immune-dysfunction.
Arun Kumar Haldar, Vinod Yadav, Eshu Singhal, Kamlesh Kumar Bisht, Alpana Singh, Suniti Bhaumik, Rajatava Basu, Pradip Sen, Syamal Roy   +8 more
doaj   +6 more sources

Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters [PDF]

Antimicrobial Agents and Chemotherapy, 2002
ABSTRACT 2-(2″-Dichloroacetamidobenzyl)-3-(3′-indolylquinoline), designated indolylquinoline derivative A, reduced the splenic and the liver parasite burdens by >93.0% in Leishmania donovani -infected hamsters, whereas sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%.
Chiranjib, Pal, Mousumi, Raha, Anirban, Basu, Keshab Chandra, Roy, Anasuya, Gupta, Monidipa, Ghosh, Niranjan Prasad, Sahu, Sukdeb, Banerjee, Nirup Bikash, Mandal, Santu, Bandyopadhyay   +9 more
semanticscholar   +4 more sources

Skewing of Sodium Antimony Gluconate mediated therapy for a predominant Th1 during visceral leishmaniasis on triggering CD2 epitope to circumvent liver infection

Annals of Hepato-Biliary-Pancreatic Surgery, 2021
Introduction Visceral leishmaniasis (VL) is a macrophage associated disorder which is linked with a profound decrease in the immunotherapeutic potential of the infected subjects leading to a marked reduction in the CD4 linked Th1 protective immune response.
Sukrat Sinha
semanticscholar   +5 more sources

Combination Therapy Using Sodium Antimony Gluconate in Stearylamine-Bearing Liposomes against Established and ChronicLeishmania donovaniInfection in BALB/c Mice [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACTIn this work we report the activity seen with combination therapy using sodium antimony gluconate in liposomes composed of egg phosphatidyl choline and stearylamine for elimination ofLeishmania donovaniparasites from the liver and spleen of BALB/c mice with established and chronic infections.
Swati, Pal, Rajesh, Ravindran, Nahid, Ali   +2 more
semanticscholar   +4 more sources

In Vitro Low Responsiveness of Leishmania donovani Towards Sodium Antimony Gluconate

Bangladesh Journal of Medical Microbiology, 2016
Kala-azar has been uprising concomitantly with drug-resistant strains of the causatinve agent, particularly in the neighbouring India. The actual perspective of drug resistance in Leishmania donovani in Bangladesh is yet to be explored. So, this prospective study, as a preliminary one, was done to observe in vitro drug responsiveness against Sodium ...
Abdullah Akhtar Ahmed, Md. Akram Hossain, Mesbah Uddin Ahmed, Md Chand Mahmud, Abul Hossain Khan, AKM Musa, AKM Shamsuzzaman, Murshed Alam   +7 more
semanticscholar   +4 more sources

In Vitro Susceptibility of Field Isolates of Leishmania donovani to Miltefosine and Amphotericin B: Correlation with Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity [PDF]

Antimicrobial Agents and Chemotherapy, 2009
ABSTRACT Indian Leishmania donovani isolates ( n = 19) from regional zones representing various levels of antimony resistance displayed significantly ( P < 0.01) correlated results with respect to in vitro susceptibility to the antileishmanial drugs sodium
Dhiraj, Kumar, Arpita, Kulshrestha, Ruchi, Singh, Poonam, Salotra   +3 more
semanticscholar   +4 more sources

Proteome mapping of overexpressed membrane‐enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania donovani [PDF]

British Journal of Clinical Pharmacology, 2010
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Over 60% of patients with visceral leishmaniasis (VL) in India and Sudan have become unresponsive to treatment with pentavalent antimonials, the first line of drugs for over 60 years. The drug resistance mechanism, studied so far in in vitro selected laboratory strains, has been attributed to various ...
Awanish, Kumar, Brijesh, Sisodia, Pragya, Misra, Shyam, Sundar, Ajit Kumar, Shasany, Anuradha, Dube   +5 more
semanticscholar   +5 more sources

Clinical and Infective Outcome of Parasitologicaly Confirmed Kala-Azar Patients Treated with Sodium Antimony Gluconate

Journal of Medicine, 1970
A total of fifty consecutive cases of Kala-azar admitted in the medicine units of Rajshahi Medical College Hospital during the period from February 2006 to October 2006 were included in this study. The number of the patients clearly indicates that the burden of Kala-azar in this region is significant and expanding.
Quazi Tarikul Islam, Ahsan Habib, Azizul Haque Azad, HAM Nazmul Ahasan, Md Mahmudur Rahman Siddiqui, Ahmed Hossain   +5 more
semanticscholar   +4 more sources

Sodium Antimony Gluconate leads to a predominant protective response during Visceral Leishmaniasis on triggering CD2 epitope [PDF]

International Journal of Infectious Diseases, 2018
S. Sinha, S. Sundaram
semanticscholar   +3 more sources

Retraction: Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation [PDF]

PLoS Pathogens
Johannes Haybaeck
doaj   +3 more sources