Results 171 to 180 of about 10,791 (213)

The ability of certain antimutagenic agents to prevent development of antibiotic resistance

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2001
Resistance to multiple antimicrobial agents has now become a prominent fact of contemporary life. It is believed that poor patient compliance, e.g. interrupted or premature cessation of therapy; and misuse or abuse of antibiotics, e.g. wrong antibiotic or insufficient dose, play important roles in resistance development.
S P, Pillai, C A, Pillai, D M, Shankel, L A, Mitscher   +3 more
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Antimutagenic Agents from Natural Products

Journal of Natural Products, 1992
Certain secondary metabolites found in terrestrial and marine plants and organisms have evinced the capability for inhibiting the mutagenicity toward Salmonella typhimurium of a number of mutagens. These include 2-aminoanthracene (2AN), ethylmethanesulfonate (EMS), and benzo-[a]pyrene(B[alpha]P).
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Antimutagens as cancer chemopreventive agents in the diet

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1994
It has been suggested that the use of antimutagens and anticarcinogens in everyday life will be the most effective procedure for preventing human cancer and genetic disease. There are several ways in which mutagenesis can be reduced or prevented. Chemicals which act to interfere with DNA repair or with mutagen metabolism can be effective antimutagens ...
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Antimutagenic Agents from Natural Products of Terrestrial and Marine Origin

1993
Both chemists and biologists have been intrigued for many years by the role of secondary metabolites in plants of terrestrial and marine origins. Of equal interest is whether such compounds have antitumor, antiviral, or antimutagenic properties. For example, the highly active antitumor agents, camptothecin and taxol, have been isolated from the bark ...
M E, Wall, M C, Wani
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Natural antimutagenic agents may prolong efficacy of human immunodeficiency virus drug therapy

Medical Hypotheses, 1997
The long-term efficacy of new combination drug therapies for human immunodeficiency virus infection may be limited by the tendency of transfected human immunodeficiency virus to mutate to drug-resistant forms. This argues for the use of safe antimutagenic measures as adjuvants to such therapies.
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Plant Antimutagenic Agents, 4. Isolation and Structure Elucidation of Maesol, an Inactive Constituent of Maesa spp.

Journal of Natural Products, 1988
Maesol, a novel dimeric phenol, was isolated from seeds of Maesa montana and Maesa indica. Maesol was shown to have the formula C28H42O4 with structure 1, a dimeric, symmetrical 1,12-bis(3,3'-dihydroxy-4,4'-dimethyl-5,5'-dimethoxyphenyl)dodecane. It is the first compound with such structure to be isolated from plant material.
M E, Wall, M C, Wani, K, Gaetano, G, Manikumar, H, Taylor, R, McGivney   +5 more
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Isolation and Identification of Higher Plant Agents Active in Antimutagenic Assay Systems: Glycyrrhiza Glabra

1986
The reproduction and maintenance of identity of species are biological imperatives, and it is not surprising that there exist mechanisms to minimize or repair the deleterious influence of noxious chemicals in the environment on DNA. Animals tend to defend themselves through the use of enzymes which intercept aggressive chemicals and convert them to ...
L A, Mitscher, S, Drake, S R, Gollapudi, J A, Harris, D M, Shankel   +4 more
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DNA Adducts With Chlorophyll and Chlorophyllin As Antimutagenic Agents: Synthesis, Stability, and Structural Features

2004
Porphyrins and their metal derivatives are strong DNA binders with association constants of 10(5) M(-1) to 10(7) M(-1). Some of these compounds have been used for radiation sensitization therapy of cancer and are targeted to interact with cellular DNA.
Heidar-Ali, Tajmir-Riahi, Jean-Francois, Neault, Stavroula, Diamantoglou   +2 more
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Plant Antimutagenic Agents, 5. Isolation and Structure of Two New Isoflavones, Fremontin and Fremontone from Psorothamnus fremontii

Journal of Natural Products, 1989
Two new isoflavones, fremontin and fremontone, were isolated from roots of Psorothamnus fremontii (Fabaceae), a desert plant. Compound 1 has the structure 5'-(alpha, alpha-dimethylallyl)-5,7,2',4'-tetrahydroxyisoflavone; compound 2 is similar but also contains the 3'-(gamma,gamma-dimethylallyl) substituent.
G, Manikumar, K, Gaetano, M C, Wani, H, Taylor, T J, Hughes, J, Warner, R, McGivney, M E, Wall   +7 more
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Comparative antimutagenicity of chlorophyllin and five other agents against aflatoxin B₁‐induced reversion in Salmonella typhimurium strain TA98

Teratogenesis, Carcinogenesis, and Mutagenesis, 1988
AbstractChlorophyllin was studied for its antimutagenic activity against aflatoxin B1 in Salmonella typhimurium strain TA98 using the plate‐incorporation test in the presence of S9 activation. Comparative antimutagenicity between chlorophyllin and certain commonly studied antimutagens (i.e., vitamins A, C, and E, retinoic acid, and β‐carotene) was also
W Z, Whong, J, Stewart, H E, Brockman, T M, Ong   +3 more
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