Results 161 to 170 of about 1,502,924 (201)
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Plant Antimutagenic Agents, 3. Coumarins
Journal of Natural Products, 1988Several coumarins were isolated from crude plant extracts by means of an antimutagenic assay procedure. These coumarins included psoralen from Psoralea corylifolia and imperatorin and osthol from Selinum monniere. Studies of structure-activity relationships of these and several other available coumarins were carried out with four mutagens.
Monroe E Wall, M C Wani, Mansukh C Wani
exaly +3 more sources
Antimutagenic Agents from Natural Products
Journal of Natural Products, 1992Certain secondary metabolites found in terrestrial and marine plants and organisms have evinced the capability for inhibiting the mutagenicity toward Salmonella typhimurium of a number of mutagens. These include 2-aminoanthracene (2AN), ethylmethanesulfonate (EMS), and benzo-[a]pyrene(B[alpha]P).
Monroe E Wall
exaly +3 more sources
Plant Antimutagenic Agents, 1. General Bioassay and Isolation Procedures
Journal of Natural Products, 1988An antimutagenic assay in Salmonella typhimurium has been utilized for a study of the inhibition of the mutagenic activity of 2-aminoanthracene in the presence of the Ames S-9 metabolic activation preparation by crude organic solvent extracts of plant materials. More than 2000 extracts representing 39 families have been tested to date.
Monroe E Wall, M C Wani, Mansukh C Wani
exaly +3 more sources
Journal of Natural Products, 1989
Two new compounds, cymobarbatol and 4-isocymobarbatol, were isolated from the marine alga Cymopolia barbata. The complete structures and absolute stereochemistries of these compounds were elucidated by a variety of spectroscopic techniques and X-ray crystallography. Both compounds were found to be nontoxic over a broad concentration range to Salmonella
William Gerwick +2 more
exaly +3 more sources
Two new compounds, cymobarbatol and 4-isocymobarbatol, were isolated from the marine alga Cymopolia barbata. The complete structures and absolute stereochemistries of these compounds were elucidated by a variety of spectroscopic techniques and X-ray crystallography. Both compounds were found to be nontoxic over a broad concentration range to Salmonella
William Gerwick +2 more
exaly +3 more sources
Naturally Occurring Phenolics as Antimutagenic and Anticarcinogenic Agents
Advances in Experimental Medicine and Biology, 1984Epidemiological evidence points to an inverse relationship between the consumption of vegetables and the incidence of cancer at various sites (Hirayama, 1979, 1981; Graham et al., 1978; Mettlin et al., 1981). The search for the protective components in these vegetables has focused on B-carotene and vitamin A (e.g., Bjelke, 1975; Shekelle et al., 1981 ...
Miriam P Rosin, M P Rosin, H F Stich
exaly +3 more sources
The ability of certain antimutagenic agents to prevent development of antibiotic resistance
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2001Resistance to multiple antimicrobial agents has now become a prominent fact of contemporary life. It is believed that poor patient compliance, e.g. interrupted or premature cessation of therapy; and misuse or abuse of antibiotics, e.g. wrong antibiotic or insufficient dose, play important roles in resistance development.
Lester A Mitscher +2 more
exaly +3 more sources
Journal of Natural Products, 1989
Two new isoflavones, fremontin and fremontone, were isolated from roots of Psorothamnus fremontii (Fabaceae), a desert plant. Compound 1 has the structure 5'-(alpha, alpha-dimethylallyl)-5,7,2',4'-tetrahydroxyisoflavone; compound 2 is similar but also contains the 3'-(gamma,gamma-dimethylallyl) substituent.
Monroe E Wall, M C Wani, Mansukh C Wani
exaly +3 more sources
Two new isoflavones, fremontin and fremontone, were isolated from roots of Psorothamnus fremontii (Fabaceae), a desert plant. Compound 1 has the structure 5'-(alpha, alpha-dimethylallyl)-5,7,2',4'-tetrahydroxyisoflavone; compound 2 is similar but also contains the 3'-(gamma,gamma-dimethylallyl) substituent.
Monroe E Wall, M C Wani, Mansukh C Wani
exaly +3 more sources
Cancer Letters, 1994
Sixty-two Egyptian food and medicinal preparations were extensively examined for antimutagenic/anticarcinogenic activity using short-term and host-mediated assays. The antimutagenic activity of the substances examined was ranked as follows: thirteen (strong), seven (mild) and five (weak) after metabolic activation.
Farid Badria
exaly +3 more sources
Sixty-two Egyptian food and medicinal preparations were extensively examined for antimutagenic/anticarcinogenic activity using short-term and host-mediated assays. The antimutagenic activity of the substances examined was ranked as follows: thirteen (strong), seven (mild) and five (weak) after metabolic activation.
Farid Badria
exaly +3 more sources
Journal of Natural Products, 1988
Maesol, a novel dimeric phenol, was isolated from seeds of Maesa montana and Maesa indica. Maesol was shown to have the formula C28H42O4 with structure 1, a dimeric, symmetrical 1,12-bis(3,3'-dihydroxy-4,4'-dimethyl-5,5'-dimethoxyphenyl)dodecane. It is the first compound with such structure to be isolated from plant material.
Monroe E Wall, M C Wani, Mansukh C Wani
exaly +3 more sources
Maesol, a novel dimeric phenol, was isolated from seeds of Maesa montana and Maesa indica. Maesol was shown to have the formula C28H42O4 with structure 1, a dimeric, symmetrical 1,12-bis(3,3'-dihydroxy-4,4'-dimethyl-5,5'-dimethoxyphenyl)dodecane. It is the first compound with such structure to be isolated from plant material.
Monroe E Wall, M C Wani, Mansukh C Wani
exaly +3 more sources
Effect of selected antimutagens on the genotoxicity of antitumor agents
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1998Cyclophosphamide (CP), bleomycin (BL), doxorubicin (DOX) and cisplatin (CISP) are potent antitumor drugs used worldwide against many forms of human cancer. As with most such agents, there can be physiological side-effects and the possible induction of mutations and other genotoxic effects in non-tumor cells.
J M, Gentile +4 more
openaire +2 more sources