Results 151 to 160 of about 22,037,861 (287)

Photobiomodulation restores blood–brain barrier integrity after hypoxia via endothelial von Willebrand factor modulation in a humanised tricellular transwell model

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Photobiomodulation restores blood–brain barrier (BBB) integrity following hypoxic stress. A multicellular human BBB model comprising brain microvascular endothelial cells, astrocytes and pericytes was established in a transwell system and subjected to acute hypoxia.
Mirriam Domocos   +4 more
wiley   +1 more source

Bridging nanomechanics and bioenergetics of single mitochondria by atomic force microscopy. [PDF]

open access: yesLife Sci Alliance
Zorikova EO   +5 more
europepmc   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer   +9 more
wiley   +1 more source

Extracellular flux analyses indicate low ATP yield and require refinement for accurate determination of maximal oxygen consumption rate. [PDF]

open access: yesSci Rep
Ransy C   +9 more
europepmc   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 5120-5147, August 2026.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon   +27 more
wiley   +1 more source

Cyclic electron flow around photosystem I provides energy production and photoprotection in C4 plants. [PDF]

open access: yesPlant Physiol
Nakamura A   +5 more
europepmc   +1 more source

Metformin Partially Attenuates Simvastatin‐Induced Myotoxic Responses in C2C12 Myotubes Through Metabolic Adaptation

open access: yesThe FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Simvastatin induces metabolic suppression, mitochondrial dysfunction, and atrophy‐related responses in skeletal muscle cells. In differentiated C2C12 myotubes, metformin partially attenuates these alterations by preserving myotube structural integrity, reducing cellular stress signaling, and maintaining mitochondrial network organization despite ...
Chuqi He   +6 more
wiley   +1 more source

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