Results 231 to 240 of about 21,202 (267)
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Phytochemistry and antimycobacterial activity of Chlorophytum inornatum
Phytochemistry, 2006In a project to investigate plant derived natural products from the Liliaceae with activity against fast-growing strains of mycobacteria, we have identified two new metabolites from Chlorophytum inornatum. The active principle, a new homoisoflavanone (1) was identified as 3-(4'-methoxybenzyl)-7,8-methylenedioxy-chroman-4-one. The metabolite assigned as
O’Donnell, Gemma +2 more
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Arzneimittel-Forschung, 1997
The mono-, di-, tri- and tetranitroxanthones have been tested against different mycobacteria by means of the Agar diffusion method resulting in minimum inhibitory concentrations (MIC) and for more precise interpretation by means of the bacterial growth kinetics method.
W G, Ibrom, K J, Schaper, A W, Frahm
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The mono-, di-, tri- and tetranitroxanthones have been tested against different mycobacteria by means of the Agar diffusion method resulting in minimum inhibitory concentrations (MIC) and for more precise interpretation by means of the bacterial growth kinetics method.
W G, Ibrom, K J, Schaper, A W, Frahm
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Synthetic piperine amide analogs with antimycobacterial activity
Chemical Biology & Drug Design, 2017Piperine amide analogs are synthesized by replacement of the piperidine moiety with different types of cyclic amines, including adamantyl and monoterpene‐derived fragments. The compounds are screened for activity against Mycobacterium tuberculosis H37Rv.
Irena Philipova +5 more
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Synthesis of Imidazole Derivatives with Antimycobacterial Activity
Archiv der Pharmazie, 2010Abstract4‐Substituted 1‐(p‐methoxybenzyl)imidazoles were designed and synthesized in order to mimic parts of the structure of highly potent antimycobacterial 6‐aryl‐9‐(p‐methoxybenzyl)purines. 4‐Haloimidazoles were subjected to Pd‐catalyzed cross‐coupling in order to introduce a (hetero)aryl group, or they were converted to Grignard reagents and ...
Pedro O, Miranda, Lise-Lotte, Gundersen
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A new amidrazone derivative with antimycobacterial activity
Acta Crystallographica Section C Crystal Structure Communications, 2000Of a series of pyridine-2-carboxamidrazone derivatives with activity against mycobacteria, the N(1)-[4-(1,1-dimethylpropyl)benzylidene] derivative reported here, C(18)H(22)N(4), is one of the most active. The predicted E isomer about the C11=N12 double bond is confirmed and intramolecular hydrogen bonding involving both amino H atoms helps to keep the ...
D C, Billington +3 more
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Synthesis and antimycobacterial activity of calpinactam derivatives
Bioorganic & Medicinal Chemistry Letters, 2012Synthesis of calpinactam 1, a fungal antimycobacterial metabolite, utilizing solid-phase peptide synthesis is described. To explore the structure-activity relationships of 1, its derivatives with different amino acids were also synthesized on the basis of the same synthetic strategy.
Kenichiro, Nagai +4 more
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Antimycobacterial activity of UDP-galactopyranose mutase inhibitors
International Journal of Antimicrobial Agents, 2010The galactofuran region of the mycobacterial cell wall consists of alternating 5- and 6-linked beta-d-galactofuranose (beta-D-Galf) residues, essential for viability. UDP-galactofuranose (UDP-Galf), the donor for Galf, is synthesised from UDP-galactopyranose (UDP-Galp) by the enzyme UDP-galactopyranose mutase (UGM), which is not found in humans ...
Silvia, Borrelli +8 more
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Mixed Steroidal 1,2,4,5-Tetraoxanes: Antimalarial and Antimycobacterial Activity
Journal of Medicinal Chemistry, 2002Mixed 1,2,4,5-tetraoxanes possessing simple spirocycloalkane and spirocholic acid-derived substituents were prepared and shown to have significantly higher in vitro antimalarial activity than bis-substituted tetraoxanes. Out of 41 synthesized tetraoxanes, 12 were in vitro more potent against Plasmodium falciparum chloroquine-resistant W2 clone than ...
Solaja BA +6 more
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ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. PICKERT, K. J. SCHAPER, A. W. FRAHM
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. PICKERT, K. J. SCHAPER, A. W. FRAHM
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Oxadiazole mannich bases: Synthesis and antimycobacterial activity
Bioorganic & Medicinal Chemistry Letters, 2007A series of oxadiazole mannich bases were synthesized by reacting oxadiazole derivatives, dapsone and appropriate aldehyde in the presence of methanol. The synthesized compounds were evaluated for antimycobacterial activity against M. tuberculosis H(37)Rv and INH resistant M. tuberculosis.
Mohamed Ashraf, Ali, Mohammad, Shaharyar
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