Results 1 to 10 of about 11,110 (180)

Antimycobacterial Plant Terpenoids [PDF]

Planta Medica, 2001
Abstract. Tuberculosis (TB), mainly caused by Mycobacterium tuberculosis, is the leading killer among all infectious diseases worldwide and is responsible for more than two million deaths annually. For over thirty years no antitubercular agents with new mechanisms of action have been developed.
Charles Cantrell, Scott Franzblau, Nikolaus H Fischer   +2 more
exaly   +3 more sources

Antimicrobial and Antimycobacterial Activity of Cyclostellettamine Alkaloids from Sponge Pachychalina sp.

Marine Drugs, 2006
: Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic ...
Ana Olivia De Souza, Célio Silva, Eduardo Hajdu   +2 more
exaly   +3 more sources

Antimycobacterial Mechanisms and Anti-Virulence Activities of Polyphenolic-Rich South African Medicinal Plants Against Mycobacterium smegmatis [PDF]

Microorganisms
The rise of multidrug-resistant tuberculosis (TB) necessitates alternative therapeutic sources. This study investigated the polyphenolic content and the antioxidant, antimycobacterial, and anti-virulence activities of selected medicinal plants ...
Matsilane L. Mashilo, Mashilo M. Matotoka, Peter Masoko   +2 more
doaj   +2 more sources

Antimycobacterial Activities of Endolysins Derived From a Mycobacteriophage, BTCU-1

Molecules, 2015
The high incidence of Mycobacterium infection, notably multidrug-resistant M. tuberculosis infection, has become a significant public health concern worldwide.
Chih-Chin Liu, Po-Chi Soo, Kai-Chih Chang   +2 more
exaly   +3 more sources

N-Alkoxyphenylhydroxynaphthalenecarboxamides and Their Antimycobacterial Activity [PDF]

Molecules, 2016
A series of nineteen N-(alkoxyphenyl)-2-hydroxynaphthalene-1-carboxamides and a series of their nineteen positional isomers N-(alkoxyphenyl)-1-hydroxynaphthalene-2-carboxamides were prepared and characterized. Primary in vitro screening of all the synthesized compounds was performed against Mycobacterium tuberculosis H37Ra, M. kansasii and M. smegmatis.
Alois Cizek, Michal Oravec, Jiří Koß   +2 more
exaly   +4 more sources

Design, synthesis, and in vitro biological evaluation of dehydroaripiprazole derivatives as antituberculosis agents and molecular docking study

Results in Chemistry, 2022
In this study, we describe the synthesis of novel piperazine-substituted 7-(4-chlorobutoxy) quinolin-2(1H) derivatives 5a–z, which were designed through specific structural modifications of aripiprazole.
B. Raja Sekhara Reddy, V. Pratap Reddy Gajulapalli, Estharla Madhu Rekha, Vagolu Siva Krishna, Dharmarajan Sriram, K Sudakar Babu, Eunha Kim   +6 more
doaj   +1 more source

Prospects for Adding Drugs with Known Anti-tuberculosis Activity to the Composition of Bone Cement for Treatment of Tuberculous Arthritis

Туберкулез и болезни лёгких, 2022
The objective: to evaluate the possibility of using linezolid, amikacin, levofloxacin and bedaquiline mixed with bone cement for the treatment of patients with tuberculous arthritis taking into account changes in mechanical properties of bone cement ...
E. O. Peretsmanas, V. S. Zubikov, A. E. Panova, A. N. Gracheva, A. A. Kazyulina, I. A. Gerasimov   +5 more
doaj   +1 more source

Antimycobacterial Activity of Rosmarinus officinalis (Rosemary) Extracted by Deep Eutectic Solvents

Separations, 2022
Tuberculosis (TB) is a massive problem for public health and is the leading cause of illness and death worldwide. Rosemary (Rosmarinus officinalis) is used traditionally to treat many diseases, such as infections of the lungs including pulmonary TB.
Ali Sami Dheyab, Mohammed Qahtan Kanaan, Nabeel Abood Hussein, Mohamed Khalid AlOmar, Siti Fatimah Sabran, Mohd Fadzelly Abu Bakar   +5 more
doaj   +1 more source

Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity

Biomolecules, 2022
Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such earned its place on the WHO list of priority pathogens. New antimycobacterials with a mechanism of action different to currently used agents are highly required ...
Vinod Sukanth Kumar Pallabothula, Marek Kerda, Martin Juhás, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Pavla Paterová, Jan Zitko   +7 more
doaj   +1 more source

Antimycobacterial activities of riminophenazines [PDF]

Journal of Antimicrobial Chemotherapy, 1999
Riminophenazines were specifically developed as drugs active against Mycobacterium tuberculosis but extensive research over several decades has shown that these compounds are also active against many other mycobacterial infections, particularly those caused by Mycobacterium leprae and the Mycobacterium avium complex (MAC).
V M, Reddy, J F, O'Sullivan, P R, Gangadharam   +2 more
openaire   +2 more sources