Results 31 to 40 of about 25,608 (226)

AntiMycobacterial activity of endophytic actinobacteria from selected medicinal plants

Biomedical and Biotechnology Research Journal, 2020
Background: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), poses a serious threat to human life. In addition, certain nontuberculous mycobacterial (NTM) species also cause infections in immune suppressed and even in immunocompetent ...
Alka Ashok, Usha Nandhini, Ayswarya Sreenivasan, Manigundan Kaari, Revathy Kalyanasundaram, Radhakrishnan Manikkam   +5 more
doaj   +1 more source

Protozoan-induced regulation of cyclic lipopeptide biosynthesis Is an effective predation defense mechanism for Pseudomonas fluorescens [PDF]

, 2009
Environmental bacteria are exposed to a myriad of biotic interactions that influence their function and survival. The grazing activity of protozoan predators significantly impacts the dynamics, diversification, and evolution of bacterial communities in ...
Bruijn, I., de, Cohen, M.F., Mazzola, M., Raaijmakers, J.M.   +3 more
core   +3 more sources

Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity

Pharmaceuticals, 2022
Isoniazid (INH) is one of the key molecules employed in the treatment of tuberculosis (TB), the most deadly infectious disease worldwide. However, the efficacy of this cornerstone drug has seriously decreased due to emerging INH-resistant strains of ...
Ebru Koçak Aslan, Muhammed İhsan Han, Vagolu Siva Krishna, Rasoul Tamhaev, Cagatay Dengiz, Şengül Dilem Doğan, Christian Lherbet, Lionel Mourey, Tone Tønjum, Miyase Gözde Gündüz   +9 more
doaj   +1 more source

N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—the Synthesis and Biological Evaluation of Enantiomers

Molecules, 2020
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb), each year causing millions of deaths. In this article, we present the synthesis and biological evaluations of new potential antimycobacterial compounds containing a ...
Martin Juhás, Lucie Kučerová, Ondřej Horáček, Ondřej Janďourek, Vladimír Kubíček, Klára Konečná, Radim Kučera, Pavel Bárta, Jiří Janoušek, Pavla Paterová, Jiří Kuneš, Martin Doležal, Jan Zitko   +12 more
doaj   +1 more source

Investigating the Antituberculosis Activity of Selected Commercial Essential Oils and Identification of Active Constituents Using a Biochemometrics Approach and In Silico Modeling

Antibiotics, 2022
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis which has become prevalent due to the emergence of resistant M. tuberculosis strains.
Katyna J. Boussamba-Digombou, Maxleene Sandasi, Guy P. Kamatou, Sandy van Vuuren, Rafal Sawicki, Zeynab Fakhar, Alvaro M. Viljoen   +6 more
doaj   +1 more source

New Small-Molecule Synthetic Antimycobacterials [PDF]

Antimicrobial Agents and Chemotherapy, 2005
Drugs for treating tuberculosis (TB) have been available for over half a century, and yet the incidence of disease worldwide continues to rise year by year. In 2002, the last year for which statistics are available, it is estimated that 24,000 people developed active disease and close to 5 ...
Ballell, Lluis, Field, Robert A., Duncan, Ken, Young, Robert J.   +3 more
openaire   +5 more sources

Antiprotozoal and antimycobacterial activities of Persea americana seeds [PDF]

, 2013
BACKGROUND: Persea americana seeds are widely used in traditional Mexican medicine to treat rheumatism, asthma, infectious processes as well as diarrhea and dysentery caused by intestinal parasites.
Adelina Jiménez-Arellanes, Amparo Tapia, Jorge Cornejo-Garrido, Julieta Luna-Herrera, Lilián Yépez-Mulia, Ricardo Ruiz-Nicolás   +5 more
core   +1 more source

Therapeutic Potential of Silver Nanoparticles (AgNPs) as an Antimycobacterial Agent: A Comprehensive Review

Antibiotics
The uncontrolled emergence of multidrug-resistant mycobacterial strains presents as the primary determinant of the present crisis in antimycobacterial therapeutics and underscores tuberculosis (TB) as a daunting global health concern.
Nilakshi Barua, Alak Kumar Buragohain
doaj   +1 more source

Synthesis, in-vitro antimicrobial and antitubercular screening of Schiff bases of 3-amino-1-phenyl-4- [2-(4-phenyl-1,3-thiazol-2-yl) hydrazin-1-ylidene]-4,5-dihydro-1H-pyrazol-5-one

Journal of Pharmacy and Bioallied Sciences, 2013
Purpose: Synthesis and antimicrobial activity of some Schiff bases of 3-amino-1-phenyl-4- [2-(4-phenyl-1,3-thiazol-2-yl) hydrazin-1-ylidene]-4,5-dihydro-1H-pyrazol-5-ones (TZP4a-l) are described.
K K Sivakumar, A Rajasekaran
doaj   +1 more source

Design, Synthesis and Evaluation of N-pyrazinylbenzamides as Potential Antimycobacterial Agents

Molecules, 2018
Three series of N-(pyrazin-2-yl)benzamides were designed as retro-amide analogues of previously published N-phenylpyrazine-2-carboxamides with in vitro antimycobacterial activity. The synthesized retro-amides were evaluated for in vitro growth inhibiting
Jan Zitko, Alžběta Mindlová, Ondřej Valášek, Ondřej Jand’ourek, Pavla Paterová, Jiří Janoušek, Klára Konečná, Martin Doležal   +7 more
doaj   +1 more source