Results 21 to 30 of about 25,608 (226)
Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636 [PDF]
, 2008 The identification of potential new anti-tubercular cemotherapeutics is paramount due to the recent emergence of extensively drug-resistant strains of Mycobacterium tuberculosis (XDR-TB).Libraries of NAS-21 and NAS-91 analogues were synthesized and ...
Besra, Gurdyal S +2 more
core +2 more sources
Toxins, 2018 Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide.
Andrea Figueroa-Montiel +5 more
doaj +1 more source
Antibacterial Activity Ods Fractions of Marine Sponge Auletta SP. Against Mycobacterium Smegmatis [PDF]
, 2019 The marine sponge collected from tropical coral reefs in Manado North Sulawesi Indonesia was screened for antimicrobial activities. In the screening program to search for antituberculotic inhibitors, the result found that the ethanol extract ODS ...
Sumilat, D. A. (Deiske)
core +2 more sources
Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A
Angewandte Chemie, EarlyView.Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham +11 more
wiley +2 more sources
Marine Drugs, 2006 : Cyclostellettamines A – F (1 – 6) isolated from the sponge Pachychalina sp. and cyclostellettamines G - I, K and L (7 – 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic ...
Roberto G. S. Berlinck +13 more
doaj +1 more source
International Journal of Mycobacteriology, 2020 Background: Tuberculosis (TB) has become a public health challenge in the current scenario with a single causative agent, Mycobacterium tuberculosis (MTB) causing the highest morbidity and mortality affecting almost 1.7 million of the population ...
Nivedita Priyadarshini +1 more
doaj +1 more source
Antimycobacterial activities of riminophenazines [PDF]
Journal of Antimicrobial Chemotherapy, 1999 Riminophenazines were specifically developed as drugs active against Mycobacterium tuberculosis but extensive research over several decades has shown that these compounds are also active against many other mycobacterial infections, particularly those caused by Mycobacterium leprae and the Mycobacterium avium complex (MAC).
V M, Reddy +2 more
openaire +2 more sources
MmpL3 is the flippase for mycolic acids in mycobacteria [PDF]
, 2017 The defining feature of the mycobacterial outer membrane (OM) is the presence of mycolic acids (MAs), which, in part, render the bilayer extremely hydrophobic and impermeable to external insults, including many antibiotics.
Chng, Shu-Sin +3 more
core +1 more source
Synthesis and antimycobacterial activity of novel heterocycles [PDF]
Journal of the Serbian Chemical Society, 2007 In the present investigation 4-hydroxy-3-methylacetophenone on condensation with various aromatic aldehydes in methanolic KOH solution yielded the corresponding chalcones (CI-CXI).
Yar Shahar M. +2 more
doaj +3 more sources
Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement
Frontiers in Cellular and Infection Microbiology, 2022 With tuberculosis, the emergence of fluoroquinolone resistance erodes the ability of treatment to interrupt the progression of MDR-TB to XDR-TB.
Amit Singh +4 more
doaj +1 more source