Results 11 to 20 of about 11,110 (180)

5-Alkylamino-N-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation

Molecules, 2020
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year.
Weronika Ambrożkiewicz, Marta Kučerová-Chlupáčová, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko   +8 more
doaj   +1 more source

Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii

Marine Drugs, 2020
Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification ...
Sara García-Davis, Karla Leal-López, Carmen A. Molina-Torres, Lucio Vera-Cabrera, Ana R. Díaz-Marrero, José J. Fernández, Pilar Carranza-Rosales, Ezequiel Viveros-Valdez   +7 more
doaj   +1 more source

Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis

Frontiers in Cellular and Infection Microbiology, 2020
Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In this study, a series of compounds was evaluated for activity against replicating Mycobacterium tuberculosis and Vero
Melissa D. Chengalroyen, Audrey Jordaan, Ronnett Seldon, Ronnett Seldon, Thomas Ioerger, Scott G. Franzblau, Mohamed Nasr, Digby F. Warner, Digby F. Warner, Valerie Mizrahi, Valerie Mizrahi   +10 more
doaj   +1 more source

In Vitro Potential of the Acetone Leaf Extract and Fractions of Psychotria capensis (Eckl.) Vatke (Rubiaceae) to Combat Co-Infection of Tuberculosis and Helminthiasis

Frontiers in Pharmacology, 2022
Tuberculosis (TB) is a disease of global importance that affects millions of people. Approximately a quarter of the world’s population is currently infected with M.
Abimbola O. Aro, Ibukun M. Famuyide, Ademola A. Oyagbemi, Prudence N. Kabongo-Kayoka, Lyndy J. McGaw   +4 more
doaj   +1 more source

In Vitro and In Silico Pharmacological and Cosmeceutical Potential of Ten Essential Oils from Aromatic Medicinal Plants from the Mascarene Islands

Molecules, 2022
In this study, 10 essential oils (EOs), from nine plants (Cinnamomum camphora, Curcuma longa, Citrus aurantium, Morinda citrifolia, Petroselinum crispum, Plectranthus amboinicus, Pittosporum senacia, Syzygium coriaceum, and Syzygium samarangense) were ...
Bibi Sharmeen Jugreet, Namrita Lall, Isa Anina Lambrechts, Anna-Mari Reid, Jacqueline Maphutha, Marizé Nel, Abdallah H. Hassan, Asaad Khalid, Ashraf N. Abdalla, Bao Le Van, Mohamad Fawzi Mahomoodally   +10 more
doaj   +1 more source

Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes

Toxins, 2018
Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide.
Andrea Figueroa-Montiel, Johanna Bernáldez, Samanta Jiménez, Beatrix Ueberhide, Luis Javier González, Alexei Licea-Navarro   +5 more
doaj   +1 more source

Antitubercular compounds isolated and characterized in Tithonia diversifolia and Couroupita guianensis

International Journal of Mycobacteriology, 2020
Background: Tuberculosis (TB) has become a public health challenge in the current scenario with a single causative agent, Mycobacterium tuberculosis (MTB) causing the highest morbidity and mortality affecting almost 1.7 million of the population ...
Nivedita Priyadarshini, Aranganathan Veeramani   +1 more
doaj   +1 more source

AntiMycobacterial activity of endophytic actinobacteria from selected medicinal plants

Biomedical and Biotechnology Research Journal, 2020
Background: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), poses a serious threat to human life. In addition, certain nontuberculous mycobacterial (NTM) species also cause infections in immune suppressed and even in immunocompetent ...
Alka Ashok, Usha Nandhini, Ayswarya Sreenivasan, Manigundan Kaari, Revathy Kalyanasundaram, Radhakrishnan Manikkam   +5 more
doaj   +1 more source

Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement

Frontiers in Cellular and Infection Microbiology, 2022
With tuberculosis, the emergence of fluoroquinolone resistance erodes the ability of treatment to interrupt the progression of MDR-TB to XDR-TB.
Amit Singh, Amit Singh, Xilin Zhao, Xilin Zhao, Karl Drlica   +4 more
doaj   +1 more source

Synthesis and antimycobacterial activity of novel heterocycles [PDF]

Journal of the Serbian Chemical Society, 2007
In the present investigation 4-hydroxy-3-methylacetophenone on condensation with various aromatic aldehydes in methanolic KOH solution yielded the corresponding chalcones (CI-CXI).
Yar Shahar M., Siddiqui Ahmad A., Ali Ashraf M.   +2 more
doaj   +3 more sources