Results 21 to 30 of about 14,174 (200)
The Spicy Story of Cannabimimetic Indoles
Molecules, 2021 The Sterling Research Group identified pravadoline as an aminoalkylindole (AAI) non-steroidal anti-inflammatory pain reliever. As drug design progressed, the ability of AAI analogs to block prostaglandin synthesis diminished, and antinociceptive activity
Allyn C. Howlett +2 more
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A Study on the Effect of Intracuneiformis Nucleus Microinjection of GABAA Receptor Agonist and Antagonist on Antinociceptive Effects of Morphine by Formalin Test in Rat [PDF]
Journal of Kerman University of Medical Sciences, 2005 In the present study, the effects of intracuneiformis nucleus microinjection of gamma-aminobutyric acidA (GABAA) receptor agonist and antagonist on antinociception inducced by morphine were investigated with formalin test in rat. Intracuneiformis nucleus
M Rezvanipour, T Safari, M Abasnejad
doaj
Journal of Pharmacological Sciences, 2009 Xylazine is an α2-adrenergic agonist extensively used in veterinary medicine and animal experimentation for producing antinociception, sedation, and muscle relaxation.
Thiago Roberto Lima Romero +1 more
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Toxins, 2023 Diabetic neuropathic pain is one of the complications that affect a wide variety of the diabetic population and is often difficult to treat. Only a small number of patients experience pain relief, which usually comes with onerous side effects and low ...
Xavier Maia Mariano +4 more
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Antinociceptive effects of counterirritants.
Folia Pharmacologica Japonica, 1994 Counterirritants such as l-menthol, methyl salicylate, camphor, thymol and capsaicin are widely used in the treatment of mild pains and itches by topical application. However, little experimental research on counterirritants has been reported. In the present study, we investigated the antinociceptive effects and mechanisms of topically applied ...
TANIGUCHI, Yasuaki +3 more
openaire +3 more sources
Molecules, 2013 Previous studies have shown that systemic administration of 6'-hydroxy-2',4'-dimethoxychalcone (flavokawin B, FKB) exerts significant peripheral and central antinociceptive effects in laboratory animals.
Daud Ahmad Israf +8 more
doaj +1 more source
Journal of Pharmacological Sciences, 2003 : The involvement of spinopetal noradrenergic and serotonergic systems in antinociception induced by endomorphin-1 (EM-1) and endomorphin-2 (EM-2) given supraspinally or spinally were investigated in male CD-1 mice.
Kuei-chun Hung +4 more
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Characterization of the Antinociceptive Activity from Stevia serrata Cav
Biomedicines, 2020 Background: Stevia serrata Cav. (Asteraceae), widely found in Guatemala, is used to treat gastrointestinal problems. The aim of this study was to demonstrate the antinociceptive and anti-inflammatory effects of the essential oil (EO) and the mechanism of
Millena S. Cordeiro +8 more
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Neural Plasticity, 2009 Chronic morphine administration shifts delta-opioid receptors (DORs) from the cytoplasm to the plasma membrane. Given that microinjection of morphine into the PAG produces antinociception, it is hypothesized that the movement of DORs to the membrane will
Michael M. Morgan +3 more
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Journal of Pharmacological Sciences, 2018 We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of ...
Toshikatsu Okumura +3 more
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