Results 41 to 50 of about 14,174 (200)

Magnesium modifies fentanyl-induced local antinociception and hyperalgesia

, 2009
PubMedID: 19697012Fentanyl-induced hyperalgesia and antinociception after systemic administration has been shown in previous clinical and experimental studies. However, there is very little evidence regarding the local possible effects of fentanyl.
Gunes Y., Ozcengiz D., Mert T., Gunay I., Dilek Ozcengiz, Ismail Gunay, Tufan Mert, Yasemin Gunes   +7 more
core   +1 more source

Comparison of mu -opioid antinociception in male and female rats.

, 2005
Male rats are more sensitive to morphine antinociception than female rats although the mechanism underlying the difference is not well understood. The present study investigated possible mechanisms utilizing both behavioral and biochemical assays.
Lapoczka, Elizabeth Marie
core   +3 more sources

Potentiation of Morphine-Induced Antinociception by Propranolol: The Involvement of Dopamine and GABA Systems

Frontiers in Pharmacology, 2017
Tolerance to the analgesic effect of morphine is a major clinical problem which can be managed by co-administration of another drug. This study investigated the ability of propranolol to potentiate the antinociceptive action of morphine and the possible ...
Elham A. Afify, Elham A. Afify, Najlaa M. Andijani   +2 more
doaj   +1 more source

Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation

Acta Amazonica, 2022
The oil of Caryocar villosum is used in Amazonian folk medicine to treat pain and inflammatory conditions. So, we assessed the anti-inflammatory and antinociceptive properties of the ethanolic extract obtained from the fruit peels of this species.
Gutemberg Lopes SOARES, Lívia Christine Ribeiro HILGENBERG, Giovana Reis BATISTA, Matheus Kleber de Jesus SOUZA, Renata Cristina Mendes FERREIRA, Irismara Sousa SILVA, Tallita Marques MACHADO, Carlos Cleomir de Souza PINHEIRO, Fernanda GUILHON-SIMPLICIO, Andre KLEIN, Andrea de Castro PEREZ, Emerson Silva LIMA, Clarice de Carvalho Veloso MOURA   +12 more
doaj   +1 more source

Opioid Receptor Internalization Contributes to Dermorphin-Mediated Antinociception

, 2010
Microinjection of opioids into the ventrolateral periaqueductal gray (vlPAG) produces antinociception in part by binding to mu-opioid receptors (MOPrs).
Aicher, Sue A., Macey, Tara A, Bobeck, Erin N, Aicher, Sue A, Ingram, Susan L., Morgan, Michael M, Ingram, Susan L, Arttamangkul, Seksiri, Bobeck, Erin N., Macey, Tara A., Morgan, Michael M., Hegarty, Deborah M, Hegarty, Deborah M.   +12 more
core   +1 more source

Enhanced Antinociception With Repeated Microinjections of Apomorphine Into the Periaqueductal Gray of Male and Female Rats

, 2018
Dopamine neurons in the ventrolateral periaqueductal gray (PAG) have been reported to contribute to antinociception. The objective of this study was to determine how this dopamine-mediated antinociception differs from what is known about morphine-induced
Schoo, Shauna M., Shauna M. Schoo, Michael M. Morgan, Bobeck, Erin N., Morgan, Michael M., Erin N. Bobeck   +5 more
core   +1 more source

Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin

Memorias do Instituto Oswaldo Cruz, 2005
Hemopressin (PVNFKFLSH), a novel bioactive peptide derived from the alpha1-chain of hemoglobin, was originally isolated from rat brain homogenates.
Camila Squarzoni Dale, Rosana de Lima Pagano, Vanessa Rioli   +2 more
doaj   +1 more source

mu/delta Cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat

, 2015
We previously demonstrated that noxious peripheral stimulation (e.g. subdermal capsaicin injection in the hind paw) produces antinociception that is mediated by opioid receptors in nucleus accumbens.
Schmidt, BL, Gear, RW, Tambeli, CH, Levine, JD   +3 more
core   +1 more source

Neural basis for improgan antinociception [PDF]

Neuroscience, 2010
Improgan, the prototype compound of a novel class of non-opioid analgesic drugs derived from histamine antagonists, attenuates thermal and mechanical nociception in rodents following intracerebroventricular (i.c.v.) administration. Improgan does not bind to known opioid, histamine or cannabinoid receptors, and its molecular target has not been ...
M M, Heinricher, M E, Martenson, J W, Nalwalk, L B, Hough   +3 more
openaire   +2 more sources

Antinociceptive effect of citronellal in mice [PDF]

Pharmaceutical Biology, 2010
Citronellal is a monoterpene reported to be a major component of the essential oils in various aromatic species of plants. The present study evaluated the central nervous system depressant and antinociceptive properties of citronellal through behavioral experimental models.
M S, Melo, L C S, Sena, F J N, Barreto, L R, Bonjardim, J R G S, Almeida, J T, Lima, D P, De Sousa, L J, Quintans-Júnior   +7 more
openaire   +2 more sources