Results 31 to 40 of about 14,174 (200)

Oxypeucedanin attenuates neuropathic pain in male mice via inhibiting lysophosphatidic acid receptor signaling

iScience
Summary: Oxypeucedanin (OPD) showed anti-allodynia against neuropathic pain (NeuP) in our previous study. In the present study, we aimed to further investigate whether lysophosphatidic acid receptor (LPAR) signaling mediated OPD-induced antinociception ...
Jiejia Li, Wenting Tang, Liyun Wang, Yipeng Gu, Wenhui You, Wenxin Yang, Yanlong Huang, Xinyue Yu, Ruiyang Zhu, Yue Xu, Junxu Li, Qing Zhu   +11 more
doaj   +1 more source

Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects

Molecules, 2023
The κ-opioid receptor (KOR) has recently emerged as an alternative therapeutic target for the development of pain medications, without deleterious side effects associated with the μ-opioid receptor (MOR).
Federica Santino, Luca Gentilucci
doaj   +1 more source

D-Cysteine Ethyl Ester Reverses the Deleterious Effects of Morphine on Breathing and Arterial Blood–Gas Chemistry in Freely-Moving Rats

Frontiers in Pharmacology, 2022
Cell-penetrant thiol esters including the disulfides, D-cystine diethyl ester and D-cystine dimethyl ester, and the monosulfide, L-glutathione ethyl ester, prevent and/or reverse the deleterious effects of opioids, such as morphine and fentanyl, on ...
Paulina M. Getsy, Santhosh M. Baby, Walter J. May, Alex P. Young, Benjamin Gaston, Matthew R. Hodges, Hubert V. Forster, James N. Bates, Christopher G. Wilson, Tristan H. J. Lewis, Yee-Hee Hsieh, Stephen J. Lewis, Stephen J. Lewis   +12 more
doaj   +1 more source

Nicotine Effects and the Endogenous Opioid System

Journal of Pharmacological Sciences, 2014
.: Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins,
Shiroh Kishioka, Norikazu Kiguchi, Yuka Kobayashi, Fumihiro Saika   +3 more
doaj   +1 more source

Morphine-induced antinociception and tolerance: Spinal versus supraspinal actions.

, 1989
Morphine-induced antinociception and tolerance: Spinal versus supraspinal ...
Judith A. Siuciak (2219068)
core   +2 more sources

The mixture of Agrimonia pilosa Ledeb. and Salvia miltiorrhiza Bunge. extract produces analgesic and anti-inflammatory effects in a collagen-induced arthritis mouse model

Animal Cells and Systems, 2022
Pain and inflammation typically manifest in patients with arthritis. It is now widely known that Agrimonia pilosa Ledeb (AP) and Salvia miltiorrhiza Bunge (SM) exert anti-inflammatory and antinociceptive effects.
Jing Hui Feng, Jeon Sub Jung, Seung Hwan Hwang, Soo Kyeong Lee, Sang Youn Lee, Youn Gil Kwak, Doo-Ho Kim, Chu-Youn Song, Min Jung Kim, Hong Won Suh, Sung Chan Kim, Soon Sung Lim   +11 more
doaj   +1 more source

Antinociceptive activity of doliroside B

Pharmaceutical Biology, 2023
Dolichos trilobus Linn (Leguminosae) is often used in Yi ethnic medicine to treat pain, fracture, and rheumatism. To explore the therapeutic potential of doliroside B (DB) from D. trilobus and its disodium salt (DBDS) and the underlying mechanism in pain.
Xishan Bai, Yanhong Li, Yuxiao Li, Min Li, Ming Luo, Kai Tian, Mengyuan Jiang, Yong Xiong, Ya Lu, Yukui Li, Haibo Yu, Xiangzhong Huang   +11 more
openaire   +3 more sources

S-Ketamine oral thin film—Part 2: Population pharmacodynamics of S-ketamine, S-norketamine and S-hydroxynorketamine

Frontiers in Pain Research, 2022
Ketamine is a versatile drug used for many indications and is administered via various routes. Here, we report on the pharmacodynamics of sublingual and buccal fast-dissolving oral-thin-films that contain 50 mg of S-ketamine in a population of healthy ...
Pieter Simons, Erik Olofsen, Monique van Velzen, Maarten van Lemmen, Tom van Dasselaar, Patrick Mohr, Florian Hammes, Rutger van der Schrier, Marieke Niesters, Albert Dahan   +9 more
doaj   +1 more source

GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception neuromodulation

Scientific Reports
We investigated the participation of the nucleus of the tractus solitarius (NTS) in tonic‒clonic seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS GABAergic interneurons and noradrenergic pathways from the locus ...
Marcelo Mendonça-dos-Santos, Thaís Cristina Teixeira Gonçalves, Luiz Luciano Falconi-Sobrinho, Tayllon dos Anjos-Garcia, Ivair Matias, Rithiele Cristina de Oliveira, Maria de Fátima dos Santos Sampaio, Fabrízio dos Santos Cardoso, Wagner Ferreira dos Santos, Helio Rubens Machado, Norberto Cysne Coimbra   +10 more
doaj   +1 more source

Pain modulation and Histopathological effects of the Hydroalcoholic extract of Capparis spinosa on mice model of Orofacial formalin test: an experimental study

Electronic Physician, 2019
Background: Orofacial pain is a form of inflammatory pain usually treated with corticosteroids, which have many side effects. Objective: The aim of this study was to investigate the clinical and histological profile of antinociceptive effects of ...
Arezou Rayyani, Safoura Seifi, Roja Askian, Manouchehr Ashrafpour, Sohrab Kazemi, Ali Akbar Moghadamnia, Hemmat Gholinia   +6 more
doaj   +1 more source