Results 41 to 50 of about 24,005 (140)

Antinociceptive and Anti-Inflammatory Activity from Algae of the Genus Caulerpa

Marine Drugs, 2011
Marine natural products have been the focus of discovery for new products of chemical and pharmacological interest. The aim of this study was to evaluate the antinociceptive activity of the methanolic (ME), acetate (AE), hexanic (HE) and chloroform (CE ...
Bárbara Viviana de Oliveira Santos, Magna Suzana Alexandre-Moreira, João Xavier de Araújo-Júnior, José Maria Barbosa-Filho, George Emmanuel C. de Miranda, Luiz Henrique Agra Cavalcante-Silva, Aline Cavalcanti de Queiroz, Morgana Vital de Araújo, Daysianne Pereira de Lira, Éverton Tenório de Souza, Carolina Babosa Brito da Matta   +10 more
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

A review on phyto‑pharmacological potentials of Euphorbia thymifolia L.

Ancient Science of Life, 2013
Euphorbia thymifolia L. (Euphorbiaceae) is a small branched, hispidly pubescent, prostate annual herb, commonly known as laghududhika or choti-dudhi. The leaves, seeds and fresh juice of whole plant are used in worm infections, as stimulant, astringent ...
Prashant Y Mali, Shital S Panchal
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

The Pharmaceutical Potential of α- and β-Amyrins

Nutraceuticals
Plant-derived pharmaceuticals represent a highly compelling area of research and continue to attract significant interest from countries, regions, scientific communities, and pharmaceutical companies worldwide.
Tran Duc Viet, La Hoang Anh, Tran Dang Xuan, Ngo Duy Dong   +3 more
doaj   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Ayahuasca, Pain, and Inflammation: A Systematic Review of Preclinical Studies

Psychoactives
Pain is a protective mechanism that can be classified into acute and chronic types. Ayahuasca is a psychoactive brew rich in dimethyltryptamine or DMT (a 5-HT2A receptor agonist), and harmine (a monoamine-oxidase (MAO) inhibitor) used for religious and ...
Bianca Villanova, Giordano Novak Rossi, Lorena Terene Lopes Guerra, José Carlos Bouso, Jaime Eduardo Cecilio Hallak, Rafael Guimarães dos Santos   +5 more
doaj   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Synergistic and dose-dependent pharmacological effects of black shallot and nano-curcumin combination on nociceptive, pyretic, and inflammatory responses in murine models

BioTechnologia
Background Inflammation, pain, and fever are common features of chronic diseases and are often inadequately controlled by existing therapies. This study evaluated a fixed-ratio combination of black shallot extract and nano-curcumin (EBSC) for dose ...
Nhung Thi Phuong Tran, Ngan Thi Nguyen, Quan Hong Bui   +2 more
doaj   +1 more source

Polymethoxyflavones from Nicotiana plumbaginifolia (Solanaceae) Exert Antinociceptive and Neuropharmacological Effects in Mice

Frontiers in Pharmacology, 2018
Polymethoxylavones (PMFs) are known to exhibit significant anti-inflammatory and neuroprotective properties. Nicotiana plumbaginifolia, an annual Bangladeshi herb, is rich in polymethoxyflavones that possess significant analgesic and anxiolytic ...
Md. Shafiullah Shajib, Ridwan B. Rashid, Long C. Ming, Long C. Ming, Shanta Islam, Md. Moklesur R. Sarker, Lutfun Nahar, Satyajit D. Sarker, Bidyut K. Datta, Mohammad A. Rashid   +9 more
doaj   +1 more source