Results 21 to 30 of about 24,005 (140)

Analgesic Potential of Essential Oils

Molecules, 2015
Pain is an unpleasant sensation associated with a wide range of injuries and diseases, and affects approximately 20% of adults in the world. The discovery of new and more effective drugs that can relieve pain is an important research goal in both the ...
José Ferreira Sarmento-Neto, Lázaro Gomes do Nascimento, Cícero Francisco Bezerra Felipe, Damião Pergentino de Sousa   +3 more
doaj   +1 more source

In Vitro and In Vivo Biological Activities of Cissus adnata (Roxb.)

Biomedicines, 2017
This study was conducted to evaluate the in vitro polyphenol content, antioxidant, cytotoxic, antibacterial, anthelmintic properties, and in vivo antinociceptive activity of the ethanol extract of Cissus adnata leaves (EECA) in different experimental ...
Mohammed Shoibe, Md. Nazim Uddin Chy, Morshed Alam, Md. Adnan, Md. Zobidul Islam, Shababa Wajida Nihar, Nishat Rahman, Ehsan Suez   +7 more
doaj   +1 more source

The Involvement of l-Arginine-Nitric Oxide-cGMP-ATP-Sensitive K⁺ Channel Pathway in Antinociception of BBHC, a Novel Diarylpentanoid Analogue, in Mice Model

Molecules, 2021
The present study focuses on the possible involvement of l-arginine-nitric oxide-cGMP-ATP-sensitive K+ channel pathway in the antinociceptive activity of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC ...
Hui Ming Ong, Ahmad Farhan Ahmad Azmi, Sze Wei Leong, Faridah Abas, Enoch Kumar Perimal, Ahmad Akira Omar Farouk, Daud Ahmad Israf, Mohd Roslan Sulaiman   +7 more
doaj   +1 more source

A Behavioral Study of Promethazine Interaction with Analgesic Effect of Diclofenac: Pain Combination Therapy

Journal of Pharmacopuncture, 2020
Pain is considered as a cause of sickness and the most prevalent symptom which makes people visit a physician. Nowadays, combination therapy is becoming useful to relieve chronic and postsurgical pain. The aim of this study was to study the promethazine (
Niloofar Amidi, Zohreh Izadidastenaei, Malihe Araghchian, Davoud Ahmadimoghaddam   +3 more
doaj   +1 more source

Anti-Inflammatory and Antinociceptive Activities of the Essential Oil of Tagetes parryi A. Gray (Asteraceae) and Verbenone

Molecules, 2022
Tagetes parryi is a plant empirically used to treat gastrointestinal and inflammatory diseases, its essential oil (EOTP) was obtained from the aerial parts, and the composition was elucidated by GC-MS.
Hansel E. González-Velasco, María S. Pérez-Gutiérrez, Ángel J. Alonso-Castro, Juan R. Zapata-Morales, Perla del C. Niño-Moreno, Nimsi Campos-Xolalpa, Marco M. González-Chávez   +6 more
doaj   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Evaluation of Antinociceptive Effects of Chitosan-Coated Liposomes Entrapping the Selective Kappa Opioid Receptor Agonist U50,488 in Mice

Medicina, 2021
Background and Objectives: The selective kappa opioid receptor agonist U50,488 was reported to have analgesic, cough suppressant, diuretic and other beneficial properties.
Liliana Mititelu Tartau, Maria Bogdan, Beatrice Rozalina Buca, Ana Maria Pauna, Cosmin Gabriel Tartau, Lorena Anda Dijmarescu, Eliza Gratiela Popa   +6 more
doaj   +1 more source

Anti-inflammatory, Antinociceptive, and Antioxidant Activities of Methanol and Aqueous Extracts of Anacyclus pyrethrum Roots

Frontiers in Pharmacology, 2017
Anacyclus pyrethrum (L.) is a plant widely used in Moroccan traditional medicine to treat inflammatory and painful diseases. The objective of the present study was to evaluate the antinociceptive, anti-inflammatory and antioxidant activities of aqueous ...
Houria Manouze, Otmane Bouchatta, A. Chemseddoha Gadhi, Mohammed Bennis, Zahra Sokar, Saadia Ba-M’hamed   +5 more
doaj   +1 more source