Results 11 to 20 of about 24,005 (140)

Ruellia simplex C. Wright (Acanthaceae): Antinociceptive, anti-inflammatory, and antidiabetic activities of a novel fatty acid isolated from its leaf extract

open access: yesInternational Journal of Plant Based Pharmaceuticals, 2022
Ruellia simplex is a medicinal plant whose leaf is used to treat pains, inflammation, and diabetes in Nigeria. The current study was undertaken to determine the antinociceptive (analgesics), anti-inflammatory, and antidiabetic activities of a novel fatty
Cletus Anes Ukwubile   +3 more
doaj   +1 more source

Antinociceptive Activity of Stephanolepis hispidus Skin Aqueous Extract Depends Partly on Opioid System Activation

open access: yesMarine Drugs, 2013
Stephanolepis hispidus is one of the most common filefish species in Brazil. Its skin is traditionally used as a complementary treatment for inflammatory disorders.
Hugo Castro-Faria-Neto   +8 more
doaj   +1 more source

One Pot Synthesis, Biological Efficacy of AuNPs and Au-Amoxicillin Conjugates Functionalized with Crude Flavonoids Extract of Micromeria biflora

open access: yesMolecules, 2023
Amoxicillin is the most widely used antibiotic in human medicine for treating bacterial infections. However, in the present research, Micromeria biflora’s flavonoids extract mediated gold nanoparticles (AuNPs) were conjugated with amoxicillin (Au-amoxi ...
Kamran Jalil   +11 more
doaj   +1 more source

Anti-inflammatory and antinociceptive activities of Rhipicephalus microplus saliva

open access: yesAsian Pacific Journal of Tropical Biomedicine, 2018
Objective: To evaluate the antinociceptive and anti-inflammatory activities and the toxic effects of Rhipicephalus microplus saliva for elucidating the modulation mechanism between arthropod saliva and host. Methods: For saliva collection, engorged ticks
D F Buccini   +5 more
doaj   +1 more source

Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels

open access: yesFrontiers in Pharmacology, 2021
Despite potently inhibiting the nociceptive voltage-gated sodium (Nav) channel, Nav1.7, µ-theraphotoxin Pn3a is antinociceptive only upon co-administration with sub-therapeutic opioid agonists, or by itself at doses >3,000-fold greater than its Nav1.7
Jeffrey R. McArthur   +5 more
doaj   +1 more source

Anti-inflammatory and antinociceptive evaluation of newly synthesized 4-(substituted ethanoyl) amino-3-mercapto-5-(4-methoxy) phenyl-1,2,4-triazoles

open access: yesJournal of Pharmacy and Bioallied Sciences, 2011
Introduction: 1,2,4-triazoles and its derivatives have been reported to possess anti-inflammatory, analgesic, antimicrobial, anticancer, antitumor, antitubercular, anticonvulsant, openers of Ca-activated potassium (Maxi-K) channels, antiviral properties,
Neeraj Upmanyu   +3 more
doaj   +1 more source

Experimental evaluation of the antinociceptive and anti-inflammatory effects of rosuvastatin and its interaction with celecoxib and paracetamol [PDF]

open access: yesThe Medical Journal of Basrah University, 2015
Background: Studies revealed that statins can result in a larger mortality benefit than can be readily explained by their cholesterol-lowering effect alone. These benefits might be related to the anti-inflammatory and other effects statins may have. Aim:
Abdullah M. Jawad, Sarmad A. Kashmar
doaj   +1 more source

Therapeutic Potential of Dopamine and Related Drugs as Anti-Inflammatories and Antioxidants in Neuronal and Non-Neuronal Pathologies

open access: yesPharmaceutics, 2023
Dopamine (DA), its derivatives, and dopaminergic drugs are compounds widely used in the management of diseases related to the nervous system. However, DA receptors have been identified in nonneuronal tissues, which has been related to their therapeutic ...
Cindy Bandala   +10 more
doaj   +1 more source

Antinociceptive activity of the alkaloid extract from Kopsia macrophylla leaves in mice [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2005
The effects of the alkaloid extract from the leaves of Kopsia macrophylla Hk. f. K. (K. macrophylla) on nociceptive response using writhing, hot plate and formalin test and the antipyretic activity in yeast-induced fever in mice, were examined.
Sunisa Sengsui   +5 more
doaj  

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

open access: yesAngewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma   +5 more
wiley   +2 more sources

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