Results 251 to 260 of about 1,146,119 (350)

Chemical finger-printing, antioxidant activity and in silico validation of phytometabolites of Octhochloa compressa. [PDF]

Sci Rep
Aslam J, Hussain T, Shahzad MI, Ali HM, Aslam M, Shahid M, Jamal A, Farooq U, Asif S, Abass KS, Fouad D, Ataya FS, Ahmadova K, Chachar Z.   +13 more
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Amorphous Lycopene-PVP K30 Dispersions Prepared by Ball Milling: Improved Solubility and Antioxidant Activity. [PDF]

Polymers (Basel)
Kulawik A, Kulawik M, Rosiak N, Lu W, Cielecka-Piontek J, Zalewski P.   +5 more
europepmc   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Spleen protective role, Antiplasmodial and Antioxidant activity of Polyalthia longifolia in mice infected with Plasmodium berghei parasite. [PDF]

Vet Anim Sci
Onobrudu DA, Okpoghono J, Acha JO, Dunkwu CC, Enyi KC, Onyesom I.   +5 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

SnCl₂-catalyzed Kabachnik-Fields synthesis of α-aminophosphonates with potent antioxidant activity. [PDF]

RSC Adv
Hibot A, Hamri S, Hafid A, Khouili M, Pujol MD.   +4 more
europepmc   +1 more source

Preparation, Characterization and Antioxidant Activity of Chitosan-Nomilin (Cs-Nom) Core-Shell Structured Microcapsules

Ningwei Wang, Qin Wang, Wenjun Li, Yujie Zhou, Mengjing Guo, Yixiao Dr., Cui Cheng, Yaping Chen, Wei Li   +8 more
openalex   +1 more source