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Involvement of antioxidant enzymes in Parkinson’s disease
Pathology - Research and Practice, 2023Similar to many other diseases, the etiology of Parkinson's disease (PD) is multifactorial and includes both genetic and environmental factors. Exposure to pesticides and the production of reactive oxygen species (ROS) in the body, mainly in electron transporter complexes 1 and 2 in the inner mitochondrial membrane, are two primary environmental risk ...
Amir, Tahavvori +5 more
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Inactivation of antioxidant enzymes by peroxynitrite
Scandinavian Journal of Clinical and Laboratory Investigation, 2000Exposure of hemolysates and whole erythrocytes to peroxynitrite (bolus of 50 micromol dm(-3)-2 mmol dm(-3)) was found to inactivate erythrocyte antioxidant enzymes: glutathione peroxidase > superoxide dismutase > catalase. Inactivation of antioxidant enzymes by peroxynitrite may be one reason for the secondary oxidative stress in peroxynitrite-treated ...
A, Grzelak, M, Soszyński, G, Bartosz
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Age-associated changes in antioxidants and antioxidative enzymes in rats
Mechanisms of Ageing and Development, 1991The antioxidative defence capacity was assessed in tissues from different groups of rats at 3, 12 and 24 months of age. It was observed that the levels of antioxidants, vitamin E and ascorbic acid decreased in serum without any changes in liver; whereas reduced glutathione showed lower levels in both serum and liver with advancing age.
A K, De, R, Darad
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Journal of Sports Sciences, 2005
Free radical production increases during exercise and oxidative damage occurs in several tissues. We examined the effects of three different exercise tests on the pattern of change of erythrocyte enzyme antioxidant activities. The tests were a short maximal exercise test, a submaximal prolonged exercise test and a cycling stage during competition.
P, Tauler +7 more
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Free radical production increases during exercise and oxidative damage occurs in several tissues. We examined the effects of three different exercise tests on the pattern of change of erythrocyte enzyme antioxidant activities. The tests were a short maximal exercise test, a submaximal prolonged exercise test and a cycling stage during competition.
P, Tauler +7 more
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Role of antioxidant enzymes in brain tumours
Clinica Chimica Acta, 2000Erythrocyte antioxidant enzymes were analysed in 100 patients with intracranial neoplasm and in 47 controls. There was a significant decrease in RBC glutathione reductase (GRx) and superoxide dismutase (SOD) activity in most types of brain tumor cases.
G M, Rao +4 more
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Augmentation of antioxidant enzymes in vascular endothelium
Journal of Free Radicals in Biology & Medicine, 1986The endothelium is a key site of injury from reactive oxygen species that can potentially be protected by the antioxidant enzymes superoxide dismutase and catalase. Large proteins, such as superoxide dismutase and catalase, do not readily penetrate cell membranes, which limits their efficacy in protecting cells from cellular reactions involving both ...
J S, Beckman, R L, Minor, B A, Freeman
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Pharmacogenetics of cylic guanylate, antioxidants, and antioxidants enzymes in saccharomyces
Free Radical Biology and Medicine, 1990Supplements of antioxidants, superoxide dismutase (SOD), catalase, cyclic guanylate (cGMP), and theophylline, or omission of iron and copper from the medium are therapeutic for the inferior growth and viability of yeast mutants doubly deficient in mitochondrial and exocellular SOD isozymes under oxidative stresses.
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Antioxidant enzymes in oral verrucous carcinoma
Journal of Oral Pathology & Medicine, 2016BackgroundVerrucous carcinoma is a non‐metastasizing variant of welldifferentiated squamous cell carcinoma, which has been associated with reactive oxygen species generated by betel quid chewing. Salivary antioxidant systems have been suggested to play a protective role in reducing the oxidative damage.
Ting-Ying, Fu +3 more
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Pharmacogenetics of cyclic guanylate, antioxidants, and antioxidant enzymes in nuerospora
Free Radical Biology and Medicine, 1990Previous studies indicate that antioxidant enzyme regulatory gene mutants (Age-) of Neurospora are defective in cellular longevity and development, numerous antioxienzymes, and cAMP, and that dietary cGMP confers normal longevity. Here it is shown that cGMP also phenotypically cures the developmental and enzymatic defects.
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Antioxidant enzyme families in parasitic nematodes
Molecular and Biochemical Parasitology, 2001Parasitic nematodes, like all aerobic organisms, require antioxidant enzymes to cope with reactive oxygen species (ROS) generated during cellular metabolism. Additionally, they have to protect themselves against ROS produced by the host. Parasitic nematode enzymes that deal with the superoxide anion radical, the superoxide dismutases (SODs), have been ...
K, Henkle-Dührsen, A, Kampkötter
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