Results 151 to 160 of about 216,604 (308)

Metal protoporphyrin-induced self-assembly nanoprobe enabling precise tracking and antioxidant protection of stem cells for ischemic stroke therapy. [PDF]

Smart Med, 2023
Shu Y, Shen H, Yao M, Shen J, Yang GY, Chen H, Tang Y, Ma M.   +7 more
europepmc   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Comparative characteristics of enzymatic antioxidant protection in patients with mild cognitive decline and late-onset depression. Is a therapeutic correction possible?

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018
Free radical processes, the degree of their intensification are one of the main pathogenetic factors in the development of many diseases in old age. The purpose of this study was to identify the severity of OS in patients with mild cognitive decline ...
N. M. Zalutskaya, K. V. Ushin, L. V. Shedrina, I. A. Beltceva, E. E. Dubinina, N. G. Neznanov   +5 more
doaj  

Changes in Spermatogenesis, Lipoperoxidation Processes, and Antioxidant Protection in Men with Pathozoospermia after COVID-19. The Effectiveness of Correction with a Promising Antioxidant Complex. [PDF]

Bull Exp Biol Med, 2022
Kurashova NA, Dashiev BG, Kolesnikov SI, Dmitrenok PS, Kozlovskaya EP, Kasyanov SP, Epur NV, Usov VG, Kolesnikova LI.   +8 more
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Astaxanthin Provides Antioxidant Protection in LPS-Induced Dendritic Cells for Inflammatory Control. [PDF]

Mar Drugs, 2021
Yin Y, Xu N, Qin T, Zhou B, Shi Y, Zhao X, Ma B, Xu Z, Li C.   +8 more
europepmc   +1 more source

Oral Motion‐Powered Smart Dental Implant Abutment for In Situ Antibacterial and Cell Adhesion Through Piezoelectric Effect

Advanced Science, EarlyView.
We proposed a method based on the piezoelectric effect and fabricated an implant abutment on the basis of piezoelectric ceramic. Under physiological occlusal pressure, the oral motion‐powered smart dental implant abutments interacted with water and oxygen, promoting the formation of reactive oxygen species and achieving a synergistic and highly ...
Xiyu Shi, Xiaoyu Han, Yanhui Lu, Yuan Chai, Baiyan Xiao, Shuo Liu, Boon Chin Heng, Tingting Wu, Tingjun Li, Qiaomei Ren, Ting Song, Le Chen, Dong Han, Yaru Guo, Xuliang Deng, Xuehui Zhang   +15 more
wiley   +1 more source

High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix. [PDF]

J Cosmet Dermatol, 2022
Martín-Martínez A, Sánchez-Marzo N, Martínez-Casanova D, Abarquero-Cerezo M, Herranz-López M, Barrajón-Catalán E, Matabuena-Yzaguirre M.   +6 more
europepmc   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Indicators of antioxidant protection of blood in necrotizing ulcerative gingivitis in experimental animals. [PDF]

J Med Life, 2021
Kilmukhametova YH, Batig VM, Ostafiichuk MA, Tokar OM, Glushchenko TA, Batih IV, Sheremet MI.   +6 more
europepmc   +1 more source