Results 131 to 140 of about 4,162,843 (311)

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

Selenium-enriched yeast improves the antioxidant status and selenium body content of rainbow trout

, 2017
Selenium-enriched yeast improves the antioxidant status and selenium body content of rainbow ...
Fontagné-Dicharry, Stéphanie, Tacon, Philippe, Bouyssière, Brice, Castro, O.S., Richard, N.   +4 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Atorvastatin, lipid peroxidation and total antioxidant status

, 2021
The aim of this research is to evaluate plasma total cholesterol (TC), low dansity cholesterol (LDL-C), high dansity cholesterol (HDL-C), triglyceride (TG), malondialdehyde (MDA) and total antioxidant status (TAS) concentrations before and after the six ...
Serdaroglu, E, Demir, I, Donma, O, Konduk, T, Borlu, F, Aydemir, A   +5 more
core  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Role of ginger in fish nutrition with special emphasis on growth, health, gut and liver morphology

Journal of the World Aquaculture Society
Ginger, Zingiber officinale, is a medicinal herb widely used for its distinct flavor and medicinal properties. It contains various bioactive compounds, including zingerone, shogaols, gingerol saponin, polyphenols, and flavonoids, which confer anti ...
Ishtiyaq Ahmad, Misbah Irm, Imtiaz Ahmed, Yin Haoran, Sehrish Taj, Tahir Ahmad Bhat, Saba Khursheed Khan, Sabah Mushtaq Puswal, Hala Saber Khalil, Mentor Sopjani, Helena Peres, Caterina Faggio, Mohd Ashraf Rather, Adnan Amin   +13 more
doaj   +1 more source

Lipid, protein, DNA oxidation and antioxidant status in rheumatoid arthritis

, 2008
Objectives: To investigate lipid, protein, DNA oxidation and antioxidant status in blood and synovial fluid of rheumatoid arthritis (RA) patients and to determine the importance of oxidative stress parameters in reflecting disease ...
Hamuryudan, Vedat, Guzel, Savas, Aslan, Mahmure, Seven, Arzu   +3 more
core   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Oxidant-antioxidant status of erythrocytes in chronic obstructive pulmonary disease

, 2010
In 70 patients with COPD studied mechanisms of oxidative stress on the changes in oxidant-antioxidant status of erythrocytes. Found that the intensity of oxidative stress in red blood cells is directly dependent on the severity of the disease.
V I Kupaev, I L Davydkin, N A Mishina
core