Results 171 to 180 of about 842,941 (248)

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Therapy to teratology: chronic paternal antioxidant supplementation alters offspring placental architecture and craniofacial morphogenesis in a mouse model. [PDF]

Front Cell Dev Biol
Derrico DD, Scaturro KZ, Murray EE, Guillen E, Truss NS, Fairly KA, Higgins SL, Bhadsavle SS, Golding MC.   +8 more
europepmc   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Efficacy of antioxidant supplementation in alleviating endometriosis-related pain: insights from a systematic review and meta-analysis of RCTs. [PDF]

Reprod Biol Endocrinol
Esmaeilzadeh S, Sadrzadeh A, Moher D, Sepidarkish M, Alamolhoda SH, Mirabi P.   +5 more
europepmc   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Antioxidant Supplementation with ProCloSupp Protects Against Renal Toxicity of Atypical Antipsychotics in Rats: Implications for Safer Treatment Strategies. [PDF]

Life (Basel)
Grahovac T, Vidonja Uzelac T, Oreščanin Dušić Z, Spasić D, Mijović M, Nikolić-Kokić A, Miljević Č, Blagojević D.   +7 more
europepmc   +1 more source

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

Advanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang, Hui Wang, Hao Zhang, Zhenkuan Cao, Zehui Liu, Siying Li, Hongda Wang, Yuping Shan   +7 more
wiley   +1 more source

Impact of maternal antioxidant supplementation on ovarian development in prepuberal Iberian pig offspring. [PDF]

Transl Anim Sci
Gómez G, Heras-Molina A, Núñez Y, Sánchez-Esquiliche F, Gómez-Carballar F, Olivares Á, González-Bulnes A, Rey AI, Óvilo C, García-Casco JM, Muñoz M, López-Bote C.   +11 more
europepmc   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

The influence of antioxidant supplementation on adverse effects and tumor interaction during radiotherapy: a systematic review. [PDF]

Clin Exp Med
Limbrunner J, Doerfler J, Pietschmann K, Buentzel J, Scharpenberg M, Huebner J.   +5 more
europepmc   +1 more source