Results 201 to 210 of about 1,341,406 (339)

Antioxidant Defense System Induced by a Methanol Extract ofCaesalpinia bonducella. in Rat Liver [PDF]

open access: bronze, 2005
M Gupta   +5 more
openalex   +1 more source

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun   +10 more
wiley   +1 more source

An Antioxidant System Required for Host Protection against Gut Infection in Drosophila [PDF]

open access: bronze, 2005
Eun-Mi Ha   +7 more
openalex   +1 more source

Mucous Permeable Nanoparticle for Inducing Cuproptosis‐Like Death In Broad‐Spectrum Bacteria for Nebulized Treatment of Acute Pneumonia

open access: yesAdvanced Science, EarlyView.
Copper‐based nanoparticles doped with BSO, and modified with PEG, not only can it increase the retention ability and mucosal penetration ability in the lungs, but also induce cuproptosis‐like death in bacteria and inhibit bacterial TCA cycle. It can also inhibit bacterial quorum sensing, clear biofilms, reduce bacterial virulence, and thus exert ...
Huiqun Hu   +9 more
wiley   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

open access: yesAdvanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang   +16 more
wiley   +1 more source

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