Results 71 to 80 of about 26,003,132 (346)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Assessment of vital organ histopathology and plasma oxidative conditions of rainbow trout Oncorhynchus mykiss reared in earthen saltwater pond

RUDN Journal of Agronomy and Animal Industries, 2019
The aim of this study was to compare gill, kidney, liver and gut histopathology, and plasma antioxidant markers of rainbow trout Oncorhynchus mykiss reared in saltwater earthen ponds in Gomishan, Iran.
Seyyed Morteza Hoseini, Behrooz Gharavi, Yousef Iri   +2 more
doaj   +1 more source

The development of antioxidant system in the intestinal tract of broiler chickens

Poultry Science, 2019
The gastrointestinal tract is the site for the uptake of nutrients from the external environment. We hypothesized that the antioxidant system in the intestinal tract has a vital protective role from the oxidative damage induced by oxidants in foods.
D. Tang, Jianmin Wu, H. Jiao, Xiaojuan Wang, Jingpeng Zhao, Hai Lin   +5 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Antioxidant Responses of Cucumber (Cucumis sativus L.) Plant to Heat Stress

Türkiye Tarımsal Araştırmalar Dergisi, 2021
The aim of this this study is to study the antioxidant responses of cucumber (Cucumis sativus L.) cultivar, Beith Alpha F1, under heat stress (45 °C and 55 °C, 4 hours).
Ali DOĞRU
doaj   +1 more source

Thioredoxin and Glutaredoxin Systems Antioxidants Special Issue [PDF]

Antioxidants, 2019
The special issue on Thioredoxin and Glutaredoxin systems (http://www [...]
Jacquot, Jean-Pierre, Zaffagnini, Mirko
openaire   +5 more sources

In vitro ion chelating, antioxidative mechanism of extracts from fruits and barks of tetrapleura tetraptera and their protective effects against fenton mediated toxicity of metal ions on liver homogenates [PDF]

, 2015
The aim of the present study was to investigate the antioxidant activity and protective potential of T. tetraptera extracts against ion toxicity. The antioxidant activity of the extracts was investigated spectrophotometrically against several radicals (1,
Biapa, P. C. N., Bravi, Marco, Moukette, B. M., Ngogang, J. Y., Njimou, J. R., Pieme, C. A., Stoller, Marco   +6 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling [PDF]

, 2014
This investigation examined the impact of Montmorency tart cherry concentrate (MC) on physiological indices of oxidative stress, inflammation and muscle damage across 3 days simulated road cycle racing.
Alessio, Bitsch, Delgado, Emma Stevenson, Felgines, Fossati, Gareth Davison, Girotti, Glyn Howatson, Goldfarb, Ian Walshe, Kelley, Phillip Bell, Phillips, Sies, Starkie   +15 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source