Results 291 to 300 of about 793,612 (344)

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

Micronutrient antioxidant supplementation alleviates valproic acid-induced oxidative stress and male infertility via the NRF2/HO-1 pathway. [PDF]

Redox Biol
Asghar MA, Wan B, Li L, Zhang J, Tang S, Han H, Yang Y, Chu L, Zhang Q, Zhang X, Zhao Q.   +10 more
europepmc   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

Advances in the Astonishing World of Phytochemicals: State-of-the-Art for Antioxidants-2nd Edition. [PDF]

Antioxidants (Basel)
Lauricella M, D'Anneo A.
europepmc   +1 more source

A Mass Spectrometry Approach Reveals Fatty Acid Isomerism in Tomato Cold Tolerance

Advanced Science, EarlyView.
An enhanced mass spectrometry approach reveals fatty acids (FAs) and FA isomers that are critical for tomato cold tolerance. Applying specific FA isomers can partially rescue cold sensitivity in tomato mutant plants, highlighting the importance of FA isomers in plant cold stress adaptation.
Leelyn Chong, Hengxue Shi, Qirui Yu, Xiaoning Shi, Zhaoxing Jia, Ziyun Dong, Yu Xia, Yingfang Zhu   +7 more
wiley   +1 more source

Biodegradable Pectin/Starch-Based Films Applied on Fresh Pears

ACS Omega
Marina L. C. Chaves, Guilherme A. M. Jesus, Michael C. Castro, Andressa R. S. Bruni, Johny P. Monteiro, Oscar O. SantosJunior, Alessandro F. Martins, Elton G. Bonafé   +7 more
doaj   +1 more source

Effects of Water-Soluble and Fat-Soluble Antioxidant Combinations in Oil-in-Water Emulsions on the Oxidative Stability of Walnut Kernels. [PDF]

Foods
Jing Y, Wang R, Wen H, Xie J.
europepmc   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Oxidative Stress and Down Syndrome: A Systematic Review. [PDF]

Antioxidants (Basel)
Slivšek G, Mijač S, Dolanc I, Fabijanec M, Petković S, Mautner R, Lončarek K, Kranjčić J, Blagaić AB, Marinović M, Vitale K, Verbanac D, Čoklo M, Vraneković J.   +13 more
europepmc   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che, Tengjiao Wang, Hongbo Wei, Peng Li   +9 more
wiley   +1 more source