Results 121 to 130 of about 3,292,255 (346)

The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa

The FEBS Journal, EarlyView.
Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte, Mariana N. R. Trujilho, Karolaine S. S. M. Valdivia, Aline F. Araujo, Laura M. C. de Lorena, Vinicius H. de Oliveira, Beatriz V. Pereira, Emilly R. Leme, Wagner A. S. Júdice, Maurício F. M. Machado   +9 more
wiley   +1 more source

Peptidomimetic and Organometallic Derivatives of Primaquine Active against Leishmania infantum [PDF]

, 2012
The current treatment of visceral leishmaniasis is made difficult by the low efficacy, elevated costs, low bioavailability, and high toxicity of many of the available drugs.
Ana Tomas, Joana Matos, Maria Salome Gomes, Nuno Vale, Paula Gomes, Rui Moreira, Silvia Vale Costa   +6 more
core   +1 more source

Development, Synthesis and Antiprotozoal Assessment of New Substituted Diquinolinyl-Pyridine Derivatives as Antiparasitic Agents by Potential G-4 Binding

, 2023
Rabindra Nath Das, Anita Cohen, Clotilde Boudot, Solène Savrimoutou, Sandra Albenque-Rubio, Stéphane Moreau, Jean‐Louis Mergny, Luisa Ronga, Ioannis Kanavos, Charles Descamps, Valentin Verdier, Patrice Agnamey, Catherine Mullié, Bertrand Courtioux, Pascal Sonne, Jean Guillon   +15 more
openalex   +1 more source

Looking for Greener Pastures: In Vitro Screening of Phytogenics for the Control of Sparicotyle chrysophrii in Gilthead Sea Bream

Journal of Fish Diseases, EarlyView.
ABSTRACT The gill parasite Sparicotyle chrysophrii poses a significant threat to gilthead sea bream (Sparus aurata) aquaculture in the Mediterranean, causing considerable mortality and economic losses. As traditional chemotherapeutic treatments, like formalin, face growing regulatory restrictions, there is an urgent need for alternative control ...
Teresa Pirollo, Ana León, Monica Caffara, Alice Caneschi, Itziar Estensoro, Jinni Gu, Maurizio Scozzoli, Ariadna Sitjà‐Bobadilla, Oswaldo Palenzuela   +8 more
wiley   +1 more source

Pumpkin seed oil: unveiling its potential in controlling inflammation and pathogenicity during experimental trichinellosis

BMC Veterinary Research
Background This study aimed to investigate the antiparasitic and anti-inflammatory potential of pumpkin seed oil in mice infected with Trichinella spiralis by demonstrating its impact on MMP-9 expression and pathogenesis during the intestinal and ...
Sara Salah Abdel-Hakeem, Sulaiman Mohammed Alnasser, Alotaibi Meshal, Mahmoud Abdel-Zaher Abdel-Samiee, Mohamed Salah Eldin Youssef, Shimaa Hamdi Abd Elsadek, Salwa Mahmoud Abd-Elrahman   +6 more
doaj   +1 more source

New Data on Molecular Targets of Tamoxifen Besides Estrogen Receptors, Their Clinical Significancy

Антибиотики и Химиотерапия, 2020
Tamoxifen is the first target agent with a high-end position in breast cancer therapy till now. In recent years experimental researches revealed new biological effects of tamoxifen on tumor cells.
T. A. Bogush, B. B. Polezhaev, E. A. Dudko, E. A. Bogush, V. Yu. Kirsanov, B. E. Polotsky, S. A. Tjuljandin, M. I. Davydov   +7 more
doaj  

Activity of benzimidazoles against Dientamoeba fragilis (Trichomonadida, Monocercomonadidae) in vitro and correlation of beta-tubulin sequences as an indicator of resistance [PDF]

, 2014
Recently, Dientamoeba fragilis has emerged as a significant and common enteropathogen. The majority of patients with dientamoebiasis present with gastrointestinal complaints and chronic symptoms are common. Numerous studies have successfully demonstrated
Barratt, JLN, Ellis, J, Harkness, JT, Marriott, D, Roberts, T, Stark, D   +5 more
core   +1 more source

Bath Treatments With Emamectin Benzoate Control Dactylogyrideans Infecting Colossoma macropomum Gills Without Altering Physiology of This Host Fish

Journal of Fish Diseases, EarlyView.
ABSTRACT Intensification of fish aquaculture worldwide has led to severe problems of diseases caused by parasitic dactylogyrideans. In this study, the anti‐dactylogyridean efficacy of treating Colossoma macropomum with baths of emamectin benzoate (EMB) was investigated for the first time, along with the effects of this treatment on the haematology and ...
Raimundo Rosemiro de Jesus Baia, Marcela Nunes Videira, Amanda Mendes Pacheco, Eliane Tie Oba Yoshioka, Marcos Tavares‐Dias   +4 more
wiley   +1 more source

Electron Transfer-oxy Radical Mechanism for Anti-cancer Agents: 9-anilinoacridines [PDF]

, 1987
A possible mode of action involving electron transfer is advanced for the 9- anilinoacridines. The mechanism entails formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Kovacic, Peter, Ryan, Michael D.   +2 more
core   +1 more source

Lactoferrin efficiently counteracts the inflammation-induced changes of the iron homeostasis system in macrophages [PDF]

, 2017
Human lactoferrin (hLf), an 80-kDa multifunctional iron-binding cationic glycoprotein, is constitutively secreted by exocrine glands and by neutrophils during inflammation. hLf is recognized as a key element in the host immune defense system.
Aisen, Andrews, Baker, Barber, Cairo, Corna, Cutone, De Domenico, Donovan, Frazer, Frioni, Ganz, Ganz, Genin, Legrand, Mackenzie, Mazumder, Miller, Musci, Paesano, Paesano, Paesano, Paesano, Park, Puddu, Puddu, Recalcati, Ross, Scorneaux, Theil, Valenti, Ward   +31 more
core   +2 more sources