Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone [PDF]
Marine Drugs, 2020 The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal
Concetta Imperatore +13 more
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Identification of a Drosophila melanogaster Glutamate-gated Chloride Channel Sensitive to the Antiparasitic Agent Avermectin [PDF]
Journal of Biological Chemistry, 1996 Glutamate-gated chloride channels, members of the ligand-gated ion channel superfamily, have been shown in nematodes and in insects to be a target of the antiparasitic agent avermectin.
Doris Cully +4 more
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Zinc(II)-Sterol Hydrazone Complex as a Potent Anti-Leishmania Agent: Synthesis, Characterization, and Insight into Its Mechanism of Antiparasitic Action [PDF]
Pharmaceutics, 2023 Searching for new alternatives for treating leishmaniasis, we present the synthesis, characterization, and biological evaluation against Leishmania amazonensis of the new ZnCl2(H3)2 complex.
Gonzalo Visbal +6 more
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Phosphonium lipocations as antiparasitic agents [PDF]
Bioorganic & Medicinal Chemistry Letters, 2012 Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P.
Timothy E, Long +5 more
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Advancing Trypanosoma cruzi N-myristoyltransferase as a drug target for Chagas disease through in silico discovery and biochemical evaluation [PDF]
Frontiers in Molecular BiosciencesIntroductionN-myristoylation is a crucial lipid modification that governs protein localization, intracellular trafficking, and function in eukaryotic cells.
Diana González García +11 more
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The effects of LED Spectra on synthesis of antiparasitic bioactive compound in Eurycoma longifolia hairy root culture against Blastocystis Sp [PDF]
Scientific ReportsEurycoma longifolia (also known as Tongkat Ali) is one of the valuable medicinal plants frequently used as traditional medicine in Malaysia. Its alkaloids and quassinoids reportedly confers antiparasitic activities. The effect of different Light Emitting
Mahmoud Ali Khalaf Abushattal +7 more
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Ivermectin as an Antiparasitic Agent in Cattle
Modern veterinary practice, 1983 In experimental trials on cattle, ivermectin given SC at 200 micrograms/kg had 95% or better efficacy against adult and immature GI and pulmonary nematodes, including inhibited fourth-stage larvae of Ostertagia ostertagi.
W. H. D. Leaning
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Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent [PDF]
Antimicrobial Agents and Chemotherapy, 2017 James H Mckerrow, Sharon L Reed
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A Review of FDA-Approved Antiparasitic Drugs in USA for Sheep and Goats: Their Synthesis and Pharmaceutical Use [PDF]
Trends in Pharmaceutical Sciences, 2023 This review describes the Food and Drug Administration (FDA)-approved antiparasitic drugs for sheep and goats in the USA updated to 2021. The emerging drug resistance is posing a significant burden for the treatment of parasitic infections in these small
Davide Benedetto Tiz, Črtomir Podlipnik
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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design [PDF]
Journal of Biological Chemistry, 2009 James H Mckerrow, Philip J Rosenthal
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