Results 71 to 80 of about 22,500 (289)

Evaluating 5-nitrofurans as trypanocidal agents [PDF]

, 2013
The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis.
Alvarez, G, Bot, C, Cerecetto, H, Di Maio, D, Gonzalez, M, Hall, BS, WILKINSON, SR   +6 more
core   +1 more source

Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents [PDF]

, 2023
Ricardo Ribeiro, Lia Costa, Eugénia Pinto, Emı́lia Sousa, Carla Fernandes   +4 more
openalex   +1 more source

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi

ChemMedChem, EarlyView.
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes, Markus Kohlhoff, Eduardo V. V. Varejão   +11 more
wiley   +1 more source

Bioinformatics-guided decoding of the Ancylostoma duodenale genome for the identification of potential vaccine targets

BMC Genomics
Ancylostoma duodenale, a parasitic nematode worm, is found to be involved in various infections, including intestinal blood loss, protein malnutrition, and anemia.
Mohibullah Shah, Hira Anum, Asifa Sarfraz, Md. Aktaruzzaman, Al Riyad Hasan, Muhammad Umer Khan, Khaled Fahmi Fawy, Sarah A. Altwaim, Saeed M. N. Alasmari, Abid Ali, Umar Nishan, Ke Chen   +11 more
doaj   +1 more source

Drug Induced Liver Injury by Prophylactic Administration of Albendazole

The Korean Journal of Gastroenterology, 2019
Albendazole is used as a typical antiparasitic agent worldwide. The side effects of albendazole may include nausea, vomiting, abdominal pain, dizziness, headache, alopecia, and increased liver enzymes. Mild elevation of the liver enzyme has been reported
Sang Yi Moon, Yang Hyun Baek, Sung Wook Lee   +2 more
doaj   +1 more source

Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi

Scientific Reports, 2022
Fexinidazole (FEX) is a heterocyclic compound and constitutes the first 100% oral treatment drug for African trypanosomiasis. Its effectiveness against Trypanosoma brucei encouraged the investigation of its antiparasitic potential against T.
Aline Araujo Zuma, Wanderley de Souza
doaj   +1 more source

Efficacy of Essential Oils of Thymus vulgaris and Origanum vulgare on Echinococcus granulosus [PDF]

, 2014
The aim of the present work was to determine the in vitro effect of T. vulgaris and O. vulgare essential oils against E. granulosus protoscoleces and cysts. Essential oils were added to the medium resulting in thymol final concentrations of 10 μg/mL. The
Denegri, Guillermo Maria, Eguaras, Martin Javier, Elissondo, María Celina, Gende, Liesel Brenda, Maggiore, Marina Alejandra, Pensel, Patricia Eugenia   +5 more
core   +1 more source

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, EarlyView.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Temporal Trends in the Epidemiology of Eating Disorders Between 2000 and 2022: A Danish Register Study of Their Incidence and Comorbidities

European Eating Disorders Review, EarlyView.
ABSTRACT Background Eating disorders are debilitating illnesses that often co‐occur with other psychiatric disorders and somatic diseases. Evidence indicates that the incidence of eating disorders has been increasing. We first examine the landscape of EDs over time, including the COVID‐19 period, via assessing the incidence of anorexia nervosa (AN ...
Nadia Micali, Helena L. Davies, Heidi Jeannet Graff, Laust H. Mortensen, Emilie R. Hegelund   +4 more
wiley   +1 more source