Results 81 to 90 of about 22,500 (289)

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [PDF]

, 2016
Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria.
Bandara Herath, H. M. T., Baresel, Paul, Bartlett, Marilyn S., Dhammika Nanayakkara, N. P., Fronczek, Frank R., Gettayacamin, Montip, McChesney, James D., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., Rochford, Rosemary, Sahu, Rajnish, Tekwani, Babu L., Tungtaeng, Anchalee, Van Gessel, Yvonne, Walker, Larry A., Wickham, Kristina S.   +16 more
core   +1 more source

Bioactive Phytochemical Compounds in Medicago sativa L. (Alfalfa): A Systematic Review of Biological Properties and Therapeutic Relevance in Nutraceutical and Functional Food Implications

Food Frontiers, EarlyView.
ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani, Hamid Rashidi Nodeh, Zahra Esfandiari, Giovanna Ferrentino   +3 more
wiley   +1 more source

Prevalence of intestinal protozoa infection among school-aged children on Pemba Island, Tanzania, and effect of single-dose albendazole, nitazoxanide and albendazole-nitazoxanide. [PDF]

, 2013
Pathogenic intestinal protozoa infections are common in school-aged children in the developing world and they are frequently associated with malabsorption syndromes and gastrointestinal morbidity.
Albonico, Marco, Ali, Said M, Ame, Shaali M, Bogoch, Isaac I, Keiser, Jennifer, Marti, Hanspeter, Speich, Benjamin, Utzinger, Jürg   +7 more
core   +3 more sources

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, EarlyView.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source

Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coagulant Moringa oleifera lectin (cMoL) is one of the compounds involved in the application of M. oleifera seeds for traditional water treatment methods. The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against Cryptococcus neoformans B3501 and H99 and Cryptococcus gattii R265 strains ...
Matheus Cavalcanti de Barros, Sávia Soraia Santana da Silva, Eduarda Pinto Gagliano, Alícia Natalie Silva dos Santos, Leydianne Leite de Siqueira Patriota, Gustavo Ramos Salles Ferreira, Pollyanna Michelle da Silva, Simone da Paz Leôncio Alves, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Fernanda Rafaelly Nascimento de Santana, Fabiana Aparecida Cavalcante Silva, Marilene Henning Vainstein, Luana Cassandra Breitenbach Barroso Coelho, Thâmarah de Albuquerque Lima, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva   +16 more
wiley   +1 more source

Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs

Scientific Reports
Parasitic worm infections impose a significant public health burden, affecting over 2 billion people, particularly in low-income regions. The limited efficacy of current treatments highlights the urgent need for new anthelmintic agents.
Maria E. Cirino, Thainá R. Teixeira, Alessandro M. H. Silva, Ana C. C. Borges, Lucas Fukui-Silva, Luis G. Wagner, Christiane Fernandes, Malachy McCann, André L. S. Santos, Josué de Moraes   +9 more
doaj   +1 more source

Dermatological remedies in the traditional pharmacopoeia of Vulture-Alto Bradano, inland southern Italy [PDF]

, 2008
Dermatological remedies make up at least one-third of the traditional pharmacopoeia in southern Italy. The identification of folk remedies for the skin is important both for the preservation of traditional medical knowledge and in the search for novel ...
A Pieroni, A Pieroni, A Pieroni, A Pieroni, A Pieroni, A Pieroni, A Pieroni, A Pieroni, A Pieroni, AM Scherrer, Andrea Pieroni, Bradley C Bennett, BS Nayak, C Quave, Cassandra L Quave, CL Quave, CL Quave, CR Stevens, E Lev, EM Costa-Neto, F Capasso, F Lentini, G Caneva, G Salerno, ISTAT, L Viegi, M Blumenthal, NG Passalacqua, PM Guarrera, PM Guarrera, PM Guarrera, PM Guarrera, RC de Souza Campos Fernandes, RE Uncini Manganelli, RM Klevens, RR Alves, RRN Alves, S Gibbons, S Gibbons, S Pignatti, V De Feo, VA Molochko, WK Po Shiu   +42 more
core   +3 more sources

Chemistry and Biology of Macrolide Antiparasitic Agents [PDF]

Journal of Medicinal Chemistry, 2011
Macrolide antibacterial agents inhibit parasite proliferation by targeting the apicoplast ribosome. Motivated by the long-term goal of identifying antiparasitic macrolides that lack antibacterial activity, we have systematically analyzed the structure-activity relationships among erythromycin analogues and have also investigated the mechanism of action
Younjoo, Lee, Jun Yong, Choi, Hong, Fu, Colin, Harvey, Sandeep, Ravindran, William R, Roush, John C, Boothroyd, Chaitan, Khosla   +7 more
openaire   +2 more sources

Store‐and‐Forward Teledermatological Collaboration Between Prisons and University Hospitals in Switzerland

JEADV Clinical Practice, EarlyView.
Dermatological conditions are common but often undertreated, causing unnecessary suffering. Teledermatology offers remote consultations to improve access. Our study analyzed 140 consultations in 125 inmates, mostly male with skin type IV. Itching and pain were frequent symptoms; eczema and scabies were common diagnoses.
Thaadsajini Manivannan, Ephsona Shencoru, Julia Beck, Lukas Schramm, Naomi May Mueller, Elisabeth V. Goessinger, Ralph Braun, Christian Greis   +7 more
wiley   +1 more source

Novel cruzain inhibitors for the treatment of Chagas' disease. [PDF]

, 2012
The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas' disease, affects millions of individuals and continues to be an important global health concern.
Arkin, Michelle R, Doak, Allison, Durrant, Jacob D, Keränen, Henrik, McCammon, J Andrew, Ratnam, Joseline, Rogers, Kathleen E   +6 more
core   +1 more source