Results 81 to 90 of about 3,292,255 (346)

Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. [PDF]

, 2012
Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I nitroreductases, enzymes found ...
Alsford, Alsford, Armstrong, Begleiter, Belinda S. Hall, Bern, Bienen, Bot, Brun, Bryant, Chaudhuri, Chen, Clarkson, Danson, Danson, Emma Louise Meredith, Ernster, Faeder, Fang, Fang, Fang, Fang, Garavaglia, Gascon, Goodwin, Guerra, Hall, Hall, Hall, Henderson, Hirumi, Hoet, Hu, Iyanagi, Jaiswal, Jarrom, Koder, Kubata, Müller, Nillius, Nivinskas, Nixon, O'Brien, Pal, Parkinson, Peterson, Pinto, Powis, Purkayastha, Race, Race, Ramos, Rassi, Shane R. Wilkinson, Stein, Stuart, Surve, Tatsumi, Tedeschi, Torri, Torri, Urech, Ward, Watanabe, Whiteway, Wilkinson, Yan, Zenno, Zenno   +68 more
core   +1 more source

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

Chemistry &Biodiversity, EarlyView.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy, Sivaraman Arumugam, Robin Charles Antony Arulraj, Anne Wincy Jacob Thomas, Henrique D. M. Coutinho   +4 more
wiley   +1 more source

ANTHELMINTIC DRUGS EFFICACY AGAINST BOVINE FASCIOLIASIS

Ветеринарная патология, 2022
Parasitic diseases in cattle are widespread in the territory of the Russian Federation. At the farms of Udmurtia various kinds of ruminants parasitic fauna are represented and therefore the vast use of antiparasitic drugs entails a range of problems ...
E. S. Klimova
doaj   +1 more source

Copper(II), a Peculiar Metal Ion for Complexation with Monensin A Ionophore

Chemistry – A European Journal, EarlyView.
Copper(II) forms three chiral and EPR‐active complexes with monensinate A in methanol. Beside the bis [CuL2] and mono [CuL]+ species, the new dinuclear construct [Cu2L]3+ exhibits an [ML]+‐type and a metal salt‐type copper(II) centers weakly bound to each other through counter ion(s) and thus, being magnetically independent.
Máté Levente Kis, Bálint Hajdu, Tamás Jakusch, Zoltán Kele, Petar Dorkov, Rositsa Kukeva, Ivayla Pantcheva, Béla Gyurcsik   +7 more
wiley   +1 more source

Bioinformatics-guided decoding of the Ancylostoma duodenale genome for the identification of potential vaccine targets

BMC Genomics
Ancylostoma duodenale, a parasitic nematode worm, is found to be involved in various infections, including intestinal blood loss, protein malnutrition, and anemia.
Mohibullah Shah, Hira Anum, Asifa Sarfraz, Md. Aktaruzzaman, Al Riyad Hasan, Muhammad Umer Khan, Khaled Fahmi Fawy, Sarah A. Altwaim, Saeed M. N. Alasmari, Abid Ali, Umar Nishan, Ke Chen   +11 more
doaj   +1 more source

Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [PDF]

, 2016
Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria.
Bandara Herath, H. M. T., Baresel, Paul, Bartlett, Marilyn S., Dhammika Nanayakkara, N. P., Fronczek, Frank R., Gettayacamin, Montip, McChesney, James D., Melendez, Victor, Ohrt, Colin, Reichard, Gregory A., Rochford, Rosemary, Sahu, Rajnish, Tekwani, Babu L., Tungtaeng, Anchalee, Van Gessel, Yvonne, Walker, Larry A., Wickham, Kristina S.   +16 more
core   +1 more source

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, EarlyView.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi

Scientific Reports, 2022
Fexinidazole (FEX) is a heterocyclic compound and constitutes the first 100% oral treatment drug for African trypanosomiasis. Its effectiveness against Trypanosoma brucei encouraged the investigation of its antiparasitic potential against T.
Aline Araujo Zuma, Wanderley de Souza
doaj   +1 more source

Biogenic Synthesis and Characterization of Antimicrobial and Antiparasitic Zinc Oxide (ZnO) Nanoparticles Using Aqueous Extracts of the Himalayan Columbine (Aquilegia pubiflora)

Frontiers in Materials, 2020
Herein, we report a facile, economic, one-pot green synthesis of zinc oxide nanoparticles (ZnO-NPs) for diverse biomedical applications. In the study, ZnO-NPs were synthesized using an aqueous extract of Aquilegia pubiflora as an effective reducing and ...
Hasnain Jan, M. Shah, H. Usman, M. A. Khan, M. Zia, Christophe Hano, B. Abbasi   +6 more
semanticscholar   +1 more source

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, EarlyView.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source