Arylmethylamino steroids as antiparasitic agents [PDF]
Nature Communications, 2017 Steroid units can facilitate membrane permeation and bioavailability in drugs. Here, using a medicinal chemistry program, Krieget al. identify an arylmethylamino steroid that kills Plasmodium parasites, likely through a chelate-based quinone methide ...
Reimar Krieg +19 more
doaj +9 more sources
Organoboron Compounds: Effective Antibacterial and Antiparasitic Agents [PDF]
Molecules, 2021 The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences.
Paolo Saul Coghi +4 more
doaj +3 more sources
Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents [PDF]
Marine Drugs, 2023 Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance.
Ricardo Ribeiro +4 more
doaj +3 more sources
Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents [PDF]
Molecules, 2020 Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic
Daiana K. Deda +4 more
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Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents [PDF]
Pharmaceuticals, 2016 A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b.
Jean J. Vanden Eynde +7 more
doaj +3 more sources
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases [PDF]
Molecules, 2018 Imidazolium salts are privileged compounds in organic chemistry, and have valuable biological properties. Recent studies show that symmetric imidazolium salts with bulky moieties can display antiparasitic activity against T. cruzi.
Ouldouz Ghashghaei +8 more
doaj +3 more sources
Synthesis, Characterization and Nanoformulation of Novel Sulfonamide-1,2,3-triazole Molecular Conjugates as Potent Antiparasitic Agents. [PDF]
Int J Mol Sci, 2022 Toxoplasma gondii (T. gondii) is a highly prevalent parasite that has no gold standard treatment due to the poor action or the numerous side effects.
Aljohani FS +8 more
europepmc +2 more sources
Menthol carbonates as potent antiparasitic agents: synthesis and in vitro studies along with computer-aided approaches. [PDF]
BMC Complement Med Ther, 2022 Introduction Despite the number of deaths and the significant economic and social costs associated with Chagas, Leishmaniasis and Malaria diseases worldwide, available drugs are limited and have serious side effects and high toxicity for the patient ...
Clemente CM, Robledo SM, Ravetti S.
europepmc +2 more sources
Promising antiparasitic agents from marine sponges. [PDF]
Saudi J Biol Sci, 2022 Parasitic diseases especially those prevail in tropical and subtropical regions severely threaten the lives of people due to available drugs found to be ineffective as several resistant strains have been emerged.
Mostafa O, Al-Shehri M, Moustafa M.
europepmc +2 more sources
Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review [PDF]
Marine Drugs, 2023 Parasitic diseases, especially those caused by protozoans and helminths, such as malaria, trypanosomiasis, leishmaniasis, Chagas disease, schistosomiasis, onchocerciasis, and lymphatic filariasis, are the cause of millions of morbidities and deaths every
Maria João Rodrigues +4 more
doaj +2 more sources