Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents against Trypanosoma cruzi. [PDF]
ACS Omega, 2022 Safe and effective treatments for Chagas disease, a potentially fatal parasitic infection associated with cardiac and gastrointestinal pathology and caused by the kinetoplastid parasite Trypanosoma cruzi, have yet to be developed.
Bernatchez JA +11 more
europepmc +2 more sources
Systemic and Target-Site Pharmacokinetics of Antiparasitic Agents. [PDF]
Clin Pharmacokinet, 2020 About one-sixth of the world’s population is affected by a neglected tropical disease as defined by the World Health Organization and Center for Disease Control. Parasitic diseases comprise most of the neglected tropical disease list and they are causing
Al Jalali V, Zeitlinger M.
europepmc +2 more sources
Author Correction: Arylmethylamino steroids as antiparasitic agents [PDF]
Nature Communications, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Reimar Krieg +19 more
doaj +2 more sources
Hybrids of Cinchona Alkaloids and Bile Acids as Antiparasitic Agents Against Trypanosoma cruzi. [PDF]
Molecules, 2019 The current chemotherapy of Chagas disease needs to be urgently improved. With this aim, a series of 16 hybrids of Cinchona alkaloids and bile acids were prepared by functionalization at position C-2 of the quinoline nucleus by a radical attack of a ...
Musikant D +5 more
europepmc +2 more sources
Diacetal Ditellurides as Highly Active and Selective Antiparasitic Agents toward Leishmania amazonensis. [PDF]
ACS Med Chem Lett, 2019 Leishmaniasis is a neglected tropical disease and a public health concern in at least 98 countries, affecting mainly the poorest populations. Pharmaceuticals and chemotherapies available for leishmaniasis treatment have several limitations, which clearly
Bandeira PT +6 more
europepmc +2 more sources
G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents. [PDF]
J Med Chem, 2018 G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and viruses.
Belmonte-Reche E +12 more
europepmc +2 more sources
Potential of Terpenoids and Flavonoids from Asteraceae as Anti-Inflammatory, Antitumor, and Antiparasitic Agents. [PDF]
Evid Based Complement Alternat Med, 2017 Fil: Sulsen, Valeria Patricia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Quimica y Metabolismo del Farmaco. Universidad de Buenos Aires.
Sülsen VP +4 more
europepmc +2 more sources
Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. [PDF]
Eur J Med Chem, 2016 Diarrhoeal diseases caused by the intestinal parasites Giardia lamblia and Entamoeba histolytica constitute a major global health burden. Nitroimidazoles are first-line drugs for the treatment of giardiasis and amebiasis, with metronidazole 1 being the ...
Jarrad AM +10 more
europepmc +2 more sources
Phosphonium lipocations as antiparasitic agents. [PDF]
Bioorg Med Chem Lett, 2012 Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P.
Long TE +5 more
europepmc +4 more sources
Novel Hit Compounds Against a Neglected Sexually Transmitted Infection: Synthesis and Trichomonacidal Activity of 1,3-Thiazolidin-4-One Derivatives [PDF]
PharmaceuticsBackground: Infections caused by the protozoan Trichomonas vaginalis affect millions of people worldwide and are responsible for one of the most common sexually transmitted diseases.
Alexia Brauner de Mello +8 more
doaj +2 more sources